Ist Ileum für die Bildung von Ersatzblasen geeignet?

Knop, I.; Fischer, Monika; Alexandrakis, E.; Melchior, H.

doi:10.1007/978-3-642-83800-2_98

Cited by 1 publication

(3 citation statements)

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“…[14] have instilled L-phenylalanineinto the reservoirs of 10 patients with urinary diversion via a continent ileal reservoir and also found a reduction of the absorptive capacity in these patients. Knop et al [15] reported a loss of absorption for 99mTc-MAG3 the longer the postoperative interval. Tc-MAGj is eliminated by renal tubular secretion and has lately come into use as a substitute for hippuric acid in renal function studies using nuclear medicine techniques [19], Both teams relate this loss to reduction of villous height and to villous atrophy.…”

Section: Absorption O F Vitamin B|> In Urinary Diversionmentioning

confidence: 99%

“…The destruction of the microvilli as described by Hansson ct al. [21 ], Deane et al [20] and Knop et al [ 15] might include these specific membrane receptors. Perhaps they are partially still intact in some patients with high absorp tion after a long postoperative interval.…”

Section: Absorption O F Vitamin B|> In Urinary Diversionmentioning

confidence: 99%

“…exposure to urine affects the mucosal absorption of me tabolites [14,15,18], Philipson ct al. [14] have instilled L-phenylalanineinto the reservoirs of 10 patients with urinary diversion via a continent ileal reservoir and also found a reduction of the absorptive capacity in these patients.…”

Section: Absorption O F Vitamin B|> In Urinary Diversionmentioning

confidence: 99%

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Absorption of Vitamin B<sub>12</sub> Administered to Continent Ileal Reservoirs for Urinary Diversion

Riedasch

Gröschel²,

Bubeck³

et al. 1996

Urol Int

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Urinary diversion through intestinal segments is a widely used method after radical cystectomy. During the last few years, new methods of bladder substitution, continent ileal neobladders, were developed. We used the method described by Hautmann et al. in 1986. 70 cm of ileum is used to form a reservoir. The ureters are implanted into the reservoir, which is then anastomosed to the urethral stump. A known problem when intestine is used for urinary diversion is the absorption of urinary solutes leading to metabolic disturbances. Therefore, the absorption of vitamin B₁₂, instilled into the neobladders of 20 patients, was measured and related to the postoperative interval. The results show a high absorption rate 2 weeks postoperatively that is reduced quickly and significantly (p < 0.001) within the first 10 months (from more than 30 to below 5%). One year to 23 months after the operation, some neobladders absorbed no vitamin B₁₂ at all, whereas others still absorbed significantly but only small quantities. These results may probably be attributed to the loss of villous structure as well as atrophy of the epithelial surface.

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Section: Absorption O F Vitamin B|> In Urinary Diversionmentioning

confidence: 99%

Section: Absorption O F Vitamin B|> In Urinary Diversionmentioning

confidence: 99%