Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster

Fararh, Khalid; Atoji, Yasuro; Shimizu, Yasutake; Takewaki, Tadashi

doi:10.1016/s0034-5288(02)00108-x

Cited by 116 publications

(82 citation statements)

References 21 publications

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“…In another experiment, decrease in blood glucose level together with increase in serum insulin level were observed after treatment with NSO for 4 weeks in STZ nicotinamide induced diabetic hamsters. Big areas with positive immuno-reactivity for the presence of insulin were observed in the pancreases from NSO-treated group compared to nontreated one using immunohistochemical staining [51]. This also suggests NSO helps regeneration of beta-cells and stimulates insulin secretion from them.…”

Section: Antidiabetic Activity In Stz Induced Diabetic Hamstersmentioning

confidence: 66%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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Seeds of Nigella sativa (black cumin/kalonji) used in pickles as spice, have also been traditionally used in treatment of many diseases including diabetes and hypertension. Among many activities exhibited by N. sativa and its constituents in animal experiments, antidiabetic property is most important. Thymoquinone (TQ), a volatile oil, is one of its active constituents but antidiabetic activity has also been shown by its aqueous extract and defatted extract. N. sativa may be beneficial in diabetic individuals and those with glucose intolerance as it reduces appetite, glucose absorption in intestine, hepatic gluconeogenesis, blood glucose level, cholesterol, triglycerides, body weight and simulates glucose induced secretion of insulin from beta-cells in pancreas; improves glucose tolerance as efficiently as metformin; yet it has not shown significant adverse effects and has very low toxicity. In streptozotocin (STZ) induced diabetic rats it causes gradual partial regeneration of pancreatic beta-cells, increases the lowered serum insulin concentrations and decreases the elevated serum glucose. N. sativa has antioxidant activity and protective role of TQ against development of type I diabetes may be via NO inhibitory pathway. It also exerts an insulin-sensitizing action in hepatocytes. Seeds of N. sativa have been safely consumed by human patients in many clinical trials which however were not aimed to assess its antidiabetic activity. In future clinical studies may show potential of N. sativa, its constituents or their synthetic analogues, in prevention and control of diabetes.

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Section: Antidiabetic Activity In Stz Induced Diabetic Hamstersmentioning

confidence: 66%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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“…The antilipidemic action of N. sativa oil may reside in their ability to stimulate insulin secretion and action. Fararh et al [62] investigated the possible insulinotropic properties of N. sativa oil in streptozotocin plus nicotinamide-induced diabetes mellitus in hamsters. The results of their study indicate that there is a significant decrease in blood glucose level together with significant increase in serum insulin level after treatment with N. sativa oil for 4 weeks.…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Al-Logmani¹,

Zari²

2011

JDM

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The long-term effects of Nigella sativa L. oil on some physiological parameters were investigated in normal and streptozotocin (STZ)-induced diabetic male Wistar rats. STZ-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein (LDL-cholesterol), uric acid, urea, creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) while high density lipoprotein (HDL-cholesterol) and total protein levels were significantly decreased compared to normal rats. Administration of black seed oil to diabetic rats resulted in a significant decrease in blood glucose, triglycerides, cholesterol, LDL-cholesterol ALT, AST and uric acid while HDL-cholesterol level was markedly increased compared to untreated diabetic rats after seven weeks of treatment. The results of this study indicate that the diet containing the oil of N. sativa improves the examined physiological parameters in STZ-induced diabetic rats especially when it is used for a longer period.

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“…The anti-diabetic activity of extracts of Nigella sativa 28) and certain chemicals 29,30) has been detected based on the immunohistochemical changes in insulinand glucagon-producing cells. Insulin-producing cells are generally located in the central regions and glucagon-producing cells are in peripheral regions of the pancreatic islets, and more numerous insulin-producing cells are detected than glucagon-producing cells in the vertebra.…”

Section: Discussionmentioning

confidence: 99%