Italian Validation of the 12-Item Multiple Sclerosis Walking Scale

Solaro, Claudio; Trabucco, Erika; Signori, Alessio; Cella, Matteo; Uccelli, Michele Messmer; Brichetto, Giampaolo; Cavalla, Paola; Gironi, Maira; Patti, Francesco; Prosperini, Luca

doi:10.1155/2015/540828

Cited by 15 publications

(15 citation statements)

References 18 publications

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“…6,23 Previously reported Cronbach’s alpha also confirms a high internal consistency of the items. 6,9,10,23–25 Over different language versions similar results are found. To investigate whether there are no cultural and language differences between versions, DIF analyses could be performed using “language” as group variable.…”

Section: Discussionsupporting

confidence: 76%

Evaluation of the Multiple Sclerosis Walking Scale-12 (MSWS-12) in a Dutch sample: Application of item response theory

2016

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Section: Discussionsupporting

confidence: 76%

Evaluation of the Multiple Sclerosis Walking Scale-12 (MSWS-12) in a Dutch sample: Application of item response theory

2016

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“…The questions focus on the self-perceived impact of MS on 12 dailylife locomotor activities in the last 2 weeks. The transformed total score is between 0 and 100, with higher scores indicating higher perceived walking difficulties [13,27].…”

Section: Clinical and Instrumented Assessmentmentioning

confidence: 99%

Instrumentally assessed gait quality is more relevant than gait endurance and velocity to explain patient‐reported walking ability in early‐stage multiple sclerosis

Carpinella

Gervasoni

Anastasi

et al. 2021

Euro J of Neurology

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Background and purpose People with multiple sclerosis (PwMS) often report walking limitations even when the gold standard Expanded Disability Status Scale (EDSS) indicates normal walking endurance/autonomy. The present multicenter study on early‐stage PwMS aims at analyzing which aspects are associated with patient‐reported walking limitations measured with the 12‐item Multiple Sclerosis Walking Scale (MSWS‐12). Methods Eighty‐two PwMS (EDSS ≤ 2.5) were assessed using the Fullerton Advanced Balance Scale—short (FAB‐s), the Fatigue Severity Scale (FSS) and the 6‐min Walk Test (6MWT), the latter administered also to 21 healthy subjects. Participants performed the 6MWT wearing three inertial sensors on ankles and trunk. Instrumented metrics describing gait velocity (stride length and frequency) and quality (regularity, symmetry, instability) were computed from sensor data. Fatigue (FSS), balance (FAB‐s), walking endurance (6MWT) and instrumented metrics were entered in a multiple regression model with MSWS‐12 as dependent variable. Results Gait symmetry, gait instability, fatigue and balance were significantly associated with self‐rated walking ability, whilst walking endurance and velocity were not. Fatigue, balance, gait symmetry and instability were more impaired in participants reporting mild‐to‐moderate (MSMM‐PWL, 25 ≤ MSWS‐12 < 75) compared to those reporting none‐to‐minimal (MSnm‐PWL, 0 ≤ MSWS‐12 ≤ 25) perceived walking limitations. Compared to healthy subjects, gait symmetry and stability were reduced in MSnm‐PWL and MSMM‐PWL, even in those participants with EDSS ≤ 1.5. Conclusion Instrumentally assessed gait quality aspects (symmetry and instability) are associated with patient‐reported walking ability in early‐stage PwMS and seem sensitive biomarkers to detect subtle impairments even in the earliest stages of the disease (EDSS ≤ 1.5). Future studies should assess their ability to follow walking change due to MS progression or pharmacological/rehabilitation interventions.

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“…Among the demographic factors, age and disease duration in the patients with MS were not correlated with the MSWS-12 scores, which contrasts with the findings of a previous study. 12 This discrepancy could be related to either the small number of patients included in our study or, considering that most of the patients showed relatively low EDSS scores that were not correlated with age or disease duration in our MS cohort, to specific characteristics of our cohort. These results were similar in the patients with NMOSD.…”

Section: Jcnmentioning

confidence: 76%

“…7,8 The 12-item Multiple Sclerosis Walking Scale (MSWS-12) is a commonly adopted patient-reported outcome measure used to assess the extent to which MS impacts the walking ability, 9 and it is currently the only qualitative, patient-based test that specifically measures walking disabilities. The MSWS-12 is easy to administer in a clinical setting for measuring walking difficulties in daily life, and it has been translated into various languages and validated as a useful tool in MS. [10][11][12][13][14] However, the MSWS-12 has not been validated for Korean MS patients, and moreover its applicability has not been evaluated for patients with NMOSD. The aim of this study was to adapt and validate a Korean version of the MSWS-12 for the Korean population with MS and NMOSD.…”

Section: Jcnmentioning

confidence: 99%

Validation of the Korean Version of the 12-Item Multiple Sclerosis Walking Scale and Application to Neuromyelitis Optica Spectrum Disorder

et al. 2020

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Background and Purpose Gait problems are a primary complaint in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The 12-item Multiple Sclerosis Walking Scale (MSWS-12) is a patient-reported measure assessing the impact of MS on the walking ability. We aimed to adapt and validate the Korean version of the MSWS-12 for the Korean population with MS and NMOSD. Methods Thirty-four MS and 35 NMOSD patients were recruited. The MSWS-12 questionnaire was translated into the Korean language and evaluated for its validity and reliability in these patients. Results The MS and NMOSD patients had mean ages of 35.9 and 42.1 years, respectively, median disease durations of 5.6 and 7.2 years, median Expanded Disability Status Scale (EDSS) scores of 2.75 (range, 0-6.5) and 3.5 (range, 0-7.5), and median baseline MSWS-12 total scores of 25 [interquartile range (IQR), 2.60-53.65] and 25 (IQR, 7.29-50.00). The baseline MSWS-12 total score in the patients with MS showed strong correlations with scores for the EDSS, timed 25-foot walk (T25FW), Multiple Sclerosis Impact Scale-29 (MSIS-29) physical dimension, and 36-item Short-Form Health Survey (SF-36) physical component summary (PCS), with Spearman's correlation coefficients (ρ) of 0.922, 0.756, 0.933, and-0.874, respectively. In patients with NMOSD, the baseline MSWS-12 total score showed strong correlations with scores for the EDSS, MSIS-29 physical dimension, and SF-36 PCS (ρ=0.769, 0.910, and-0.852, respectively), and moderate correlations with scores for the T25FW and Fatigue Severity Scale-9 (ρ=0.597 and 0.630, respectively). Conclusions The Korean version of the MSWS-12 appears to be a valid and reliable scale that can be used for Korean patients with MS. The MSWS-12 can also be applied to patients with NMOSD.

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Italian Validation of the 12-Item Multiple Sclerosis Walking Scale

Cited by 15 publications

References 18 publications

Evaluation of the Multiple Sclerosis Walking Scale-12 (MSWS-12) in a Dutch sample: Application of item response theory

Evaluation of the Multiple Sclerosis Walking Scale-12 (MSWS-12) in a Dutch sample: Application of item response theory

Instrumentally assessed gait quality is more relevant than gait endurance and velocity to explain patient‐reported walking ability in early‐stage multiple sclerosis

Validation of the Korean Version of the 12-Item Multiple Sclerosis Walking Scale and Application to Neuromyelitis Optica Spectrum Disorder

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