Itching is a significant problem and a mediator between disease severity and quality of life for patients with psoriasis: results from a randomized controlled trial

Zhu, Baojin; Edson-Heredia, Emily; Guo, Jiaying; Maeda-Chubachi, Tomoko; Shen, Wei; Kimball, Alexa B.

doi:10.1111/bjd.13065

Cited by 57 publications

(51 citation statements)

References 15 publications

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“…Pruritus has been suggested to be an important mediator of improvements in both disease severity and HRQoL . Specifically, pruritus seems to be an important mediator of the DLQI domains that assess symptoms and feelings, treatment satisfaction, work and school function, daily activities and leisure.…”

Section: Discussionmentioning

confidence: 99%

Rapid improvements in health‐related quality of life and itch with ixekizumab treatment in randomized phase 3 trials: results from UNCOVER‐2 and UNCOVER‐3

Leonardi

Blauvelt

Sofen

et al. 2017

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Rapid improvements in health‐related quality of life and itch with ixekizumab treatment in randomized phase 3 trials: results from UNCOVER‐2 and UNCOVER‐3

Leonardi

Blauvelt

Sofen

et al. 2017

Acad Dermatol Venereol

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“…Pruritus, especially CP, is well-known for having a severely negative impact on a patient's QoL (20)(21)(22). We utilized several questions on important aspects of QoL instead of elaborated QoL scores, such as DLQI (23) and ItchyQol (24), as these are rather complex and long.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Characteristics of Pruritus: A One-Week Cross-sectional Study in a German Dermatology Practice

Kopyciok¹,

Ständer²,

Osada³

et al. 2016

Acta Derm Venerol

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Pruritus is a frequent sensation in dermatoses, but its prevalence in patients in dermatological practices has not been fully studied. The aim of this cross-sectional study is to investigate its prevalence and characteristics in all patients attending a dermatology practice in Germany over a period of one week (n = 334; 52.7% female; median age 45.0 years). The point prevalence of pruritus in this study population was 36.2% (87.6% of whom had chronic pruritus). It inhibited the everyday life of 73.6% of all patients, with 77.7% reporting a frequently to permanently experienced moderate intensity. (5.2 ± 2.3 on the numerical rating scale). Of the patients, 52.1% had previously consulted their general practitioner, and 62% had visited the dermatologist due to pruritus. This study shows that pruritus is a highly prevalent, clinically and economically relevant symptom in dermatological practices. The majority of patients suffering from chronic pruritus are severely burdened and medically underserved. Dermatologists should be aware that pruritus also occurs frequently in patients who do not primarily present due to their symptoms.

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“…Despite this and considering its ease of use, VAS can be considered as an extremely efficient tool to measure itch intensity and potential impact on quality of life, irrespective of other factors that define the symptom. This was recently confirmed in another clinical trial related to psoriasis treatment demonstrating that improvement of HRQoL (assessed via DLQI) is mainly mediated by VAS improvement [23]. For itch intensity assessment VAS was selected, as it is currently the most commonly used, validated and monodimensional tool in self-reporting itch intensity.…”

Section: Discussionmentioning

confidence: 99%

“…CP is widely accepted as an important factor influencing HRQoL [2,3,4,5,6,7,9,10,11,12,13,16,19,20,21]. However, factors modifying the respective impact of CP are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity

Warlich¹,

Fritz

Osada

et al. 2015

Dermatology

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Background: It is unknown if health-related quality of life (HRQoL) differs between diseases associated with chronic pruritus (CP). Objective: To analyze HRQoL in relation to age, gender, skin lesions (primary vs. scratch-induced secondary) and itch intensity. Methods: Consecutive patients of our itch clinic were assessed with the Dermatology Life Quality Index (DLQI) and visual analogue scale (VAS). Results: In 510 CP patients (282 females; median age, 61.4 years), DLQI scores and VAS values were highly correlated, irrespective of the type of skin lesion. Overall, women had a lower HRQoL compared to men (females: 10.7 ± 6.7, males: 8.9 ± 6.7), but female gender was only associated with worse quality of life in patients <65 years old. Conclusion: HRQoL impairment in CP is highly influenced by pruritus intensity but not to the visible skin lesion or underlying cause. With limitations to item bias, DLQI is a suitable instrument for estimating quality of life impairment by CP.

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Itching is a significant problem and a mediator between disease severity and quality of life for patients with psoriasis: results from a randomized controlled trial

Abstract: Pruritus appears to be an important mediator of the association between improvements in disease severity and HRQOL in patients with moderate-to-severe psoriasis.

Cited by 57 publications

References 15 publications

Rapid improvements in health‐related quality of life and itch with ixekizumab treatment in randomized phase 3 trials: results from UNCOVER‐2 and UNCOVER‐3

Rapid improvements in health‐related quality of life and itch with ixekizumab treatment in randomized phase 3 trials: results from UNCOVER‐2 and UNCOVER‐3

Prevalence and Characteristics of Pruritus: A One-Week Cross-sectional Study in a German Dermatology Practice

Health-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity

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