IUse of Mean platelet Volume as an initial diagnostic marker in evaluation of dengue fever

Afsar, Nabila; Afroze, Idrees Akhtar; Humaira, Shahmeen; Abid, Zakia

doi:10.21276/apalm.1411

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…Increased platelet volume increases platelet adhesion, aggregation and synthesis of thromboxanes which can lead to complications like disseminated intravascular coagulation. [2,5] Prakash GM et al found no correlation between increased PDW and dengue fever which was concurrent with the present study where a statistical significant value was not obtained. Nehara HR et al suggested that high PDW is more sensitive for dengue hemorrhagic fever and more specific for dengue fever.…”

Section: Discussionsupporting

confidence: 90%

“…Afsar N et al also reported 86.7% of cases in their study to be under 30 years of age. [5,10] Thrombocytopenia indicates a fall in platelet count to <150 x 10 3 mm 3 . Slichter SJ et al suggested that dengue virus induces anti-platelet antibodies that cause vigorous platelet destruction through apoptosis and lysis by complement system.…”

Section: Discussionmentioning

confidence: 99%

“…Severe thrombocytopenia is directly correlated to disease severity, chances of development of complications and prognosis in the critically-ill patients. [2,5] Platelet indices include Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT) and Platelet-Large Cell Ratio (P-LCR). MPV measures the average size of platelets and provides a statement between the lower discriminator (PL) and upper discriminator (PU).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Platelet Indices as Prognostic Markers in Seropositive Cases of Dengue

S¹

2019

jmscr

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Background: Dengue fever is the most prevalent arboviral disease globally and an increasing number of cases are being reported every year. The assessment of platelet count and platelet indices at an early stage in the disease helps to predict the life-threatening complications such as Dengue Haemorrhagic Fever and Dengue Shock Syndrome. Materials and Methods: The current case-control study was undertaken at Sambhram Institute of Medical Sciences and Research, a rural tertiary care and teaching hospital in Kolar Gold Fields. During the recent dengue outbreak between June 2019 to August 2019 where in 75 seropositive cases of dengue were reported following clinical examination. Platelet count and platelet indices (Mean Platelet Volume, Platelet Distribution Width, Plateletcrit and Platelet-Large Cell Ratio) were carried out for these cases and results were tabulated. Similar tests were carried out on 75 apparently healthy controls and required parameters were obtained. Results: Platelet counts ranged from 11-429 x 10 3 mm 3 . 58 cases (77.33%) had thrombocytopenia. MPV ranged from 8-14 fL. 15 cases (20%) had increased MPV >12 fL. PDW ranged from 9-22.4. 21 cases (28%) had increased PDW > 14fL. PCT ranged from 0.04-0.36 %. 60 cases (80%) had low plateletcrit<0.22%. P-LCR ranged from 12.8-52.4 %. 13 cases (17.33%) had increased P-LCR > 35 %. Statistically significant p values were found for Platelet count (p<0.0001), MPV (p=0.0006) and PCT (p=0.0003). The p-values for PDW (0.2966) and P-LCR (0.1229) were not found to be statistically significant. Conclusion:Although dengue fever is predominant in urban and semi urban areas, an increasing in number of cases are being reported in rural areas. Platelet indices can be an early predictor of complications in dengue fever and thus benefit both Pathologists and Clinicians alike to forsee high-risk cases. It is an easily available, fast and cost effective means to ensure prompt management in a rural centers with limited resources. Platelet count, Mean platelet volume and Plateletcrit were found to be significant prognostic markers in the present study.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of Platelet Indices as Prognostic Markers in Seropositive Cases of Dengue

S¹

2019

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“…Our study showed a significantly higher MPV, PDW, and P-LCR among dengue patients when compared to the control group. Afsar et al [23] also observed a significant increase in MPV values in dengue cases when compared to control group. Contrary to this finding, in a study done by Bashir et al, [24] a decreased MPV and a high PDW were noted in dengue patients when compared to healthy controls.…”

Section: Platelet Indicesmentioning

confidence: 84%

A Study to Evaluate Use of Platelet Indices in Hyperdestructive Thrombocytopenia: A Two-year Experience from Tertiary Care Rural Hospital

Francis¹,

Shetageri²,

Roopa³

et al. 2021

JMSH

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Background: Thrombocytopenia is one of the most common causes of abnormal bleeding and is defined as platelet counts < 1.5 lakhs/cumm. Three processes can cause thrombocytopenia, namely: Deficient platelet production, accelerated platelet destruction, and abnormal pooling of the platelets within the body. Of these, accelerated platelet destruction is the most common cause for thrombocytopenia and has variety of etiologies. The usefulness of bone marrow analysis in assessing accelerated platelet destruction is still debated. Therefore, a new simple and non-invasive diagnostic approach for thrombocytopenia is needed. Aims and Objectives: The present study was done with an aim to evaluate the use of platelet indices, namely, mean platelet volume (MPV), Platelet Distribution Width (PDW), and Platelet Large Cell Ratio (P-LCR) in differentiating the various causes of hyperdestructive thrombocytopenia. Materials and Methods: This was a prospective study conducted over a period of 2 years and consisted of 206 cases of hyperdestructive thrombocytopenia. After recording relevant clinical details, platelet count along with platelet indices – MPV, PDW, and P-LCR was recorded. Based on the etiopathology identified, cases were categorized into three groups: Group I: Immunologic – cases of Immune thrombocytopenic purpura (ITP), Group II: Non-immune: Cases of sepsis and other non-immune causes of platelet destruction, and Group III: Viral and parasitic infections. Platelet indices were compared between the study groups and the control group which included 100 healthy individuals. Comparison was done among the three study groups as well. Results & Conclusions: Dengue accounted for the highest number of 131 (89.72%) cases in the study. MPV, PDW, and P-LCR were significantly higher (P < 0.0001) when compared to the healthy controls except P-LCR in Group II. A statistically significant increase in MPV was noted among ITP cases when compared to other causes of thrombocytopenia. There wa

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“…11 The tests are simple, inexpensive and non invasive. 10,[12][13][14][15][16] MPV is an indicator of platelet size and is reported as a ratio of Plateletcrit to total platelet count in Hematology Analyser by different methods like Impedence, optical light scatter counting etc. 10,11,16,17 Normal MPV range for our study is 7.5 -10.5 fl 13,16 but differ in other due to many variables.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

Joshi¹,

Sathyavathi²,

Gayathri³

et al. 2020

IJPO

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Dengue, endemic in India presents in mild to severe forms with or without bleeding. There is no specific treatment available till date hence severe dengue has to be recognized in early stages. Platelet counts are unreliable as they do not correlate with bleeding. Platelet indices have been studied for their utility as predictors of severity of the disease and aid in guide to transfusion therapy. Mean platelet volume is inexpensive and available with routine complete blood counts in hematology analyser. Its role as marker in diagnosis, prognosis and treatment of dengue has been investigated with platelet indices reports. To study MPV patterns, association with platelet counts and relevant laboratory parameters in dengue. The study was conducted over one month in the year 2016 in department of Hematology, Kempegowda Institute of Medical Sciences Hospital, Bengaluru. 100 serologically proven dengue cases were analysed with data collected from the records in the departments of Hematology and Microbiology against patient’s unique hospital identification number. There was a predominance of young male patients. The range for MPV was 8.7 – 13.2 (average 10.95) with 35% normal and 65% high MPV cases. There was 48% cases with moderately severe / severe thrombocytopenia. 32% with increased hematocrit, 35% with leucopenia, 54% with significant atypical lymphocytosis and 42% with antibody pattern. There was an increased number of high MPV seen in severe thrombocytopenia, increased hematocrit significant atypical lymphocytosis and antibody pattern whereas normal pattern was noted in leucopenia. High MPV is a useful predictor of severe dengue platelet recovery and may guide in transfusion therapy.

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IUse of Mean platelet Volume as an initial diagnostic marker in evaluation of dengue fever

Cited by 8 publications

References 9 publications

Assessment of Platelet Indices as Prognostic Markers in Seropositive Cases of Dengue

Assessment of Platelet Indices as Prognostic Markers in Seropositive Cases of Dengue

A Study to Evaluate Use of Platelet Indices in Hyperdestructive Thrombocytopenia: A Two-year Experience from Tertiary Care Rural Hospital

Mean platelet volume: Has it the capacity to predict the concentration of Platelet counts in Dengue: A study

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