2021
DOI: 10.1016/j.jns.2021.117580
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IV tPA given in the golden hour for emergent large vessel occlusion stroke improves recanalization rates and clinical outcomes

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Cited by 8 publications
(3 citation statements)
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“…Extensive efforts have been made to stratify the long-term outcomes of AIS after r-tPA ( Di Lorenzo et al, 2021 ; Goh et al, 2021 ). However, early intervention for AIS is particularly important as a disease with a high mortality and disability rate.…”
Section: Discussionmentioning
confidence: 99%
“…Extensive efforts have been made to stratify the long-term outcomes of AIS after r-tPA ( Di Lorenzo et al, 2021 ; Goh et al, 2021 ). However, early intervention for AIS is particularly important as a disease with a high mortality and disability rate.…”
Section: Discussionmentioning
confidence: 99%
“…For some patients with AIS, IV-tPA has proved to be an effective treatment as long as 4.5 h after onset ( 20 ). In recent years, increasing evidence indicated that every minute delay in IV-tPA is associated with worse clinical outcomes ( 20 , 21 ). In this study, we focused on investigating the role of hospital factors affecting delays in IV-tPA treatment for AIS patients.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the medical community model decreased length of hospital stay and hospitalization expense. Another research indicated the AIS patients receiving IV-tPA within 60 min of stroke symptom onset have a higher complete recanalization rate, showed improvement in the nervous system, and obtained better mRS scores and lower mortality at 90-day follow-up compared to the patients receiving administration after 60 min of onset ( 21 ). Tsivgoulis et al ( 30 ) found that administration of IV-tPA within “golden hour” (60 min of symptom onset) achieved favorable functional outcome (mRS ≤ 1 at 3 months) and better clinical recovery at 2 and 24 h (reduction in NIHSS score by ≥10 points or an absolute NIHSS score of ≤ 3 at 2 and 24 h, respectively).…”
Section: Discussionmentioning
confidence: 99%