Ivermectin pharmacokinetics in lactating sheep

Cerkvenik, V.; Grabnar, Iztok; Skubic, Valentin; Doganoc, Darinka Z.; Beek, W.M.J.; Keukens, H.J.; Košorok, Marinka Drobnič; Pogačnik, M.

doi:10.1016/s0304-4017(01)00612-4

Cited by 55 publications

(47 citation statements)

References 23 publications

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“…The pharmacokinetics of IVM following single subcutaneous injection of IVM or IVM in combination in both animal species used in this study was best described by a one-compartment model the same as the previous findings observed in sheep (Cerkvenik et al 2002) and cattle (Borges et al 2007). In the present work, the combination of rafoxanide and IVM in the same formulation induced a significant change in the pharmacokinetic parameters of IVM in both species.…”

Section: Discussionsupporting

confidence: 64%

“…In addition, there is an increase in the value of AUC by 15.48% while the value of elimination rate constant was decreased by 38.2% and increased the half-life time of elimination from 2.04 days for IVM alone to 3.3 days when given in combination with rafoxanide of 2.5 mg/kg. Elimination half-life (t 1/2el ) confirmed the long-lasting IVM residuals in serum and may contribute to the extremely high efficacy of IVM against parasites (Cerkvenik et al 2002). The slower excretion rate and larger AUC in IVM combination would be consistent with the increased time of exposure of the therapeutic concentrations of IVM consistent with increased preventive efficacies .…”

Section: Discussionmentioning

confidence: 75%

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Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep

et al. 2008

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This study investigated the comparative serum disposition kinetics of ivermectin (IVM) after a single subcutaneous dose of 200 microg/kg body weight of IVM alone or in combination with an anthelmintic consisting of ivermectin and rafoxanide (200 microg/kg of IVM and 2.5 mg/kg rafoxanide) for use in calves and sheep. The IVM concentrations in serum samples were analyzed by high-performance liquid chromatography with fluorescence detection. In sheep serum, rafoxanide induced a rapid absorption of IVM when given in combined form manifested by a shorter absorption half-life time of IVM by 68.49% when given in combination as compared with IVM when given alone. In addition, there is an increase in the value of the area under the concentration curve (AUC) by 15.48% while the value of elimination rate constant was decreased by 38.2% and significantly increased the half-life time of elimination from 2.04 days for IVM alone to 3.3 days when given in combination with rafoxanide. In calves serum, the mean t1/2ab for IVM/rafoxanide was 0.131 days and for the control formulation 0.16 days, and t1/2el was 5.78 and 4.95, respectively. IVM Cmax for IVM/rafoxanide was 22.4 ng/ml and for the control formulation 19.1 ng/ml. T (max) values were 0.99 and 1.12 days, and the mean AUC values were 188.9 and 165.4 ng/ml/day. The difference in Cmax, AUC, Kab, K el, and t1/2el was significant. However, there was no statistical difference between the Tmax and t1/2ab. These findings revealed that the combination of rafoxanide with IVM in sheep and calves increased the absorption of IVM and delayed its elimination.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 75%

Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep

et al. 2008

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“…The observed peak plasma concentration (C max ) observed in sheep in this study is lower than that reported after subcutaneous administration of 0.2 mg/kg by Barber and colleagues (2003); it is higher than that obtained by Cerkvenik and colleagues (2002). The AUC, which refers to the extent of absorption, is equivalent to that reported previously in sheep (Cerkvenik et al, 2002;Barber et al, 2003). The AUC values observed suggest that the pharmacokinetics of ivermectin in sheep is independent of breed.…”

Section: Discussionsupporting

confidence: 57%

“…Many pharmacokinetic studies following different routes of administration of ivermectin in sheep have been performed (Atta and Abo-Shihada, 2000;Cerkvenik et al, 2002;Echeverria et al, 2002;Barber et al, 2003;Molento et al, 2004). However, there remains a lack information about this endectocide in African breeds.…”

Section: Introductionmentioning

confidence: 99%

Ivermectin in Senegalese Peulh Sheep: Influence of Sex on Plasma Disposition

Ndong

Kane²,

Diouf³

et al. 2007

Vet Res Commun

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The plasma disposition kinetics of ivermectin following a single subcutaneous administration of 0.2 mg/kg was investigated in male and female Senegalese Peulh sheep. Ten clinically healthy animals (5 males and 5 females) weighing 38-45 kg were used in this trial. Blood samples were collected by jugular puncture at different times between 0.5 h and 30 days post treatment. After plasma extraction and derivatization, samples were analysed by HPLC with fluorescence detection. Computerized kinetic analysis was carried out and mean parameters were statistically compared with the Mann-Whitney U-test. The area under the concentration-time curve (AUC) was significantly higher (p < 0.0027) in females than in males. Although the differences in maximum concentration (C (max)), mean residence time (MRT) and half-life of elimination (t (1/2el)) between males and females did not achieve statistical significance, values tended to be higher in females. Sex differences may be parallel with the level of storage in fat. Further investigations are required to improve the use of ivermectin in Senegalese sheep and findings may be used to predict optimal anthelmintic strategies for management of African species depending on the parasites present in a production system.

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“…Several assays for the measurement of ivermectin in biological samples have been reported including HPLC [40][41][42][43][44][45] and HPLC-MS [46,47]. Kowalski et al [48] reported the first validated CEbased method for the determination of ivermectin in biological fluids [48] as an alternative to HPLC.…”

Section: Ivermectinmentioning

confidence: 99%

Pharmacokinetic applications of capillary electrophoresis: A review on recent progress

Sung

Chen

2006

Electrophoresis

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This article covers recent publications from 2003 to 2005 on the subject of pharmacokinetic applications of CE. Many analytical methods were validated and more importantly, they were shown to have sufficient sensitivities to access pharmacokinetic data on different models. Because of unique advantages, such as simplified sample preparation methods, small sample amount required, high separation power, and speedy analysis, CE-based assays were found to gain popularity not only as a second method but also as a major method for many pharmacokinetic studies.

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Ivermectin pharmacokinetics in lactating sheep

Cited by 55 publications

References 23 publications

Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep

Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep

Ivermectin in Senegalese Peulh Sheep: Influence of Sex on Plasma Disposition

Pharmacokinetic applications of capillary electrophoresis: A review on recent progress

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