Ivermectin-Responsive Crusted Scabies in HTLV1 Carrier

Abstract

We report a case of HTLV1 infection revealed by crusted scabies and widespread dermatophytosis in an African woman. HTLV1 infection was not complicated by adult T cell leukemia or myelopathy. Crusted scabies is a marker of HTLV1 infection. The importance of oral ivermectin therapy in crusted scabies is emphasized.

Scabies superimposed on skin lesions of adult T‐cell leukemia/lymphoma: case report and literature review

“…In general, the efficacy of ivermectin to ordinary scabies is high with a success rate of 70 and 74% after a single dose of 100 and 200 μ g/kg, respectively. [23][24][25] However, scabies in ATLL patients seems to be resistant to such conventional treatments, 5,7,8 as observed in our case. At present, the mechanism underlying the resistance to conventional therapies remains unknown.…”

Manifestações cutâneas da infecção e das doenças relacionadas ao vírus linfotrópico de células T humanas do tipo 1

“…Dos 16 soropositivos, um caso de ATL e quatro com HAM/TSP foram observados.Todos os demais eram infectados assintomáticos, incluindo três casos com infestações recidivantes que resultaram em dois óbitos.72 Relatos de casos de EC associados a tinhas também foram descritos em indivíduos soropositivos assintomáticos. 74,75 As micoses superficiais podem ter sua clínica modificada pela imunossupressão não só na morfologia e extensão das lesões como também na evolução. 54 Formas graves, invasivas de infecção foram descritas na ATL.…”

Review of Ivermectin in Scabies

“…A single 9-mg oral dose of Ivm (170 lg/Ivm/kg body weight) cleared the skin lesions in a few days. 38 In the study conducted by Dourmishev et al 26 described earlier, 5 immunosuppressed patients were treated with liquid Ivm (1% solution) at a dose of 200 lg/ Ivm/kg body weight weekly for 2 weeks; all were cured 1 week after the second dose of Ivm. These patients were probably included in their subsequent reports.…”