Ivy and Licorice Triterpene Glycosides: Promising Molecular Containers for Some Drugs and Biomolecules

Yakovishin, L. A.; Гришковец, В. И.

doi:10.1016/b978-0-444-64068-0.00011-5

Cited by 16 publications

(8 citation statements)

References 37 publications

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“…The absorption maximum of the solutions decreases insignificantly (hypsochromic shift) from 237 to 230 nm. Similar spectral changes were previously observed for molecular complexation of HedC with caffeine [7].…”

Section: Resultssupporting

confidence: 86%

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Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol

et al. 2020

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The 1:1 molecular complex of ivy triterpene glycoside hederasaponin C (HedC) with cholesterol (Chol) was obtained in aqueous isopropyl alcohol. The stability constant of (3.3 ± 0.7)∙106 (mol/L)–1 was calculated for the complex. The complexation was studied by UV- and ATR IR-Fourier spectroscopy, and method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex.

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Section: Resultssupporting

confidence: 86%

“…Such ratio was obtained for complex of HedC with Chol in 90% and 70% aqueous ethanol [3,4], and for complexes of HedC with several drugs [7]. Stability constant of complex (3.3 ± 0.7) • • 10 6 (mol/L) -1 was calculated based on isomolar curves (A. K. Babko method) [4,6].…”

Section: Resultsmentioning

confidence: 99%

Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol

et al. 2020

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“…Chemical composition. Flavonoids and other phenolics ( Urban, 1958 ; Trute and Nahrstedt, 1997 ; Al-Snafi, 2018 ); polyacetylenes (falcarinol, dehydrofalcarinol) ( Bohlmann et al, 1961 ; Gafner et al, 1989 ); saponins ( Elias et al, 1991 ; Crespin et al, 1995 ; Yakovishin and Grishkovets, 2018 ); and essential oils (β-caryophyllene, germacrene D, limonene, α- and β-pinene, and sabinene as the main components) ( Tucker and Maciarello, 1994 ).…”

Section: Resultsmentioning

confidence: 99%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method: The plant selection was primarily based on species listed by the WHO and EMA, but some other herbal remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical data on their efficacy and safety were collected from authoritative sources. The target population were adults with early and mild flu symptoms without underlying conditions. These were evaluated according to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The benefits/risks balance of the treatments was classified as positive, promising, negative, and unknown. Results: A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases (Allium sativum, Andrographis paniculata, Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulus essential oil, Justicia pectoralis, Magnolia officinalis, Mikania glomerata, Pelargonium sidoides, Pimpinella anisum, Salix sp, Zingiber officinale), and unknown for the rest. On the same grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. Conclusions: Our work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical

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“…The therapeutic effect of Rut is limited due to its bioavailability [1]. The study [2] showed that the solubility and bioavailability of bioactive compounds can be significantly increased by their molecular complexation with triterpene glycosides. Triterpene saponins are amphiphilic multidentate ligands that are capable of molecular complexation with both polar and non-polar fragments of other molecules [2].…”

Section: Introductionmentioning

confidence: 99%

“…Glycyrrhizic acid (GA) and its monoammonium salt (ammonium glycyrrhizate, glycyram, GC; Fig. 1) are widely used as complexing agents [2][3][4][5][6]. GA is the main triterpene saponin of licorice roots [2].…”

Section: Introductionmentioning

confidence: 99%

New molecular complex of ammonium glycyrrhizate with rutin

et al. 2022

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A new 1:1 molecular complex of triterpene glycoside ammonium glycyrrhizate (GC) with flavonoid glycoside rutin (Rut) was obtained in aqueous ethanol. The stability constant (9.7±0.2)×104 (mol/L)–1 was calculated for the complex via isomolar curves. The complexation was studied by UV- and ATR IR-Fourier spectroscopy and a method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex. A preliminary antioxidant activity assessment of the complex was made.

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Ivy and Licorice Triterpene Glycosides: Promising Molecular Containers for Some Drugs and Biomolecules

Cited by 16 publications

References 37 publications

Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol

Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

New molecular complex of ammonium glycyrrhizate with rutin

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