J591 functionalized paclitaxel-loaded PLGA nanoparticles successfully inhibited PSMA overexpressing LNCaP cells

Ehsan, Iman; Kumari, Leena; Sen, Ramkrishna; Hoque, Ashique Al; Mukherjee, Biswajit; Mukherjee, Abhik; Ghosh, Prasanta; Bhattacharya, Sanchari

doi:10.1016/j.jddst.2022.103689

Cited by 5 publications

(7 citation statements)

References 52 publications

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“…42,43 The physical characterizations followed by substantial DL and EE values ensured the successful formation of CA-loaded nanocarriers. 16,26 The sustained release pattern observed further supported the potential of prepared NPs as drug carriers. Upon fitting various pharmacokinetic models, Korsmeyer−Peppas release kinetics emerged as the best fit for the formulation, whereas Fickian diffusion emerged as the best probable model of drug release.…”

Section: Evaluation Of Systemic Toxicitysupporting

confidence: 53%

“…The current study reports the anticancer potential of CA-loaded PLGA-based nanoparticulate delivery cargo utilizing vitamin E TPGS as an emulsifying agent overcoming the bioavailability concerns. The nanoprecipitation technique yielded NPs of 124.9 nm hydrodynamic diameter which seems promising for the NPs to be considered for biological applications such as passive targeting of tumors. , The physical characterizations followed by substantial DL and EE values ensured the successful formation of CA-loaded nanocarriers. , The sustained release pattern observed further supported the potential of prepared NPs as drug carriers. Upon fitting various pharmacokinetic models, Korsmeyer–Peppas release kinetics emerged as the best fit for the formulation, whereas Fickian diffusion emerged as the best probable model of drug release.…”

Section: Resultsmentioning

confidence: 80%

“…Earlier evidence suggests a DL capacity of about 6−7% can be considered a good loading potential for anticancer agents. 16,26 Hence, it can be said that satisfactory loading and encapsulation of CA was achieved in the formulated PLGA NPs emulsified with vitamin E TPGS. Quite clearly, the formulated CA-PLGA NPs emerge as a potential candidate for biological applications.…”

Section: Resultsmentioning

confidence: 94%

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Formulation of Carnosic-Acid-Loaded Polymeric Nanoparticles: An Attempt to Endorse the Bioavailability and Anticancer Efficacy of Carnosic Acid against Triple-Negative Breast Cancer

Chatterjee,

Chakraborty,

Dutta

et al. 2024

ACS Appl. Bio Mater.

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Triple-negative breast cancer (TNBC) is considered to be one of the most difficult subtypes of breast cancer (BC) to treat. The sheer absence of certain receptors makes it very tough to target, leaving high-dose chemotherapy as probably the sole therapeutic option at the cost of nonspecific toxic effects. Carnosic acid (CA) has been established as a potential chemotherapeutic agent against a range of cancer cells. However, its in vivo chemotherapeutic potential is significantly challenged due to its poor pharmacokinetic attributes. In this study, poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) were formulated to circumvent the biopharmaceutical limitations of CA. CA-loaded polymeric NPs (CA-PLGA NPs) have been evaluated as a potential therapeutic option in the treatment of TNBC. Different in vitro studies exhibited that CA-PLGA NPs significantly provoked oxidative-stress-mediated apoptotic death in MDA-MB-231 cells. The improved anticancer potential of CA-PLGA NPs over CA was found to be associated with improved cellular uptake of the nanoformulation by TNBC cells. In vivo studies also established the improvement in the chemotherapeutic efficacy of CA-nanoformulation over that of free CA without showing any sign of systemic toxicity. Thus, CA-PLGA NPs emerge as a promising candidate to fix two bugs with a single code, resolving biopharmaceutical attributes of CA as well as introducing a treatment option for TNBC.

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Section: Evaluation Of Systemic Toxicitysupporting

confidence: 53%

Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 94%

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Formulation of Carnosic-Acid-Loaded Polymeric Nanoparticles: An Attempt to Endorse the Bioavailability and Anticancer Efficacy of Carnosic Acid against Triple-Negative Breast Cancer

Chatterjee,

Chakraborty,

Dutta

et al. 2024

ACS Appl. Bio Mater.

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“…Fungicide release from AZ-loaded MSSP nanoparticles was measured following an earlier reported procedure in the acetonitrile and water (1:1) system. , In this method, 2 mL of the nanoparticle suspension was taken in a 20 mL vial under stirring conditions. After a specified interval of time, 1 mL of the solution from the bulk was collected and centrifuged (at 15,000 rpm) for nanoparticle precipitation, and the supernatant was collected for the UV–vis spectroscopic measurement of the released AZ.…”

Section: Methodsmentioning

confidence: 99%

Biobased, Macro-, and Nanoscale Fungicide Delivery Approaches for Plant Fungi Control

Hazra

Roy

Jiang

et al. 2023

ACS Appl. Bio Mater.

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In this report, two polymeric matrix systems at macro and nanoscales were prepared for efficacious fungicide delivery. The macroscale delivery systems used millimeter-scale, spherical beads composed of cellulose nanocrystals and poly(lactic acid). The nanoscale delivery system involved micelle-type nanoparticles, composed of methoxylated sucrose soyate polyols. Sclerotinia sclerotiorum (Lib.), a destructive fungus affecting high-value industrial crops, was used as a model pathogen against which the efficacy of these polymeric formulations was demonstrated. Commercial fungicides are applied on plants frequently to overcome the transmission of fungal infection. However, fungicides alone do not persist on the plants for a prolonged period due to environmental factors such as rain and airflow. There is a need to apply fungicides multiple times. As such, standard application practices generate a significant environmental footprint due to fungicide accumulation in soil and runoff in surface water. Thus, approaches are needed that can either increase the efficacy of commercially active fungicides or prolong their residence time on plants for sustained antifungal coverage. Using azoxystrobin (AZ) as a model fungicide and canola as a model crop host, we hypothesized that the AZ-loaded macroscale beads, when placed in contact with plants, will act as a depot to release the fungicide at a controlled rate to protect plants against fungal infection. The nanoparticle-based fungicide delivery approach, on the other hand, can be realized via spray or foliar applications. The release rate of AZ from macro-and nanoscale systems was evaluated and analyzed using different kinetic models to understand the mechanism of AZ delivery. We observed that, for macroscopic beads, porosity, tortuosity, and surface roughness governed the efficiency of AZ delivery, and for nanoparticles, contact angle and surface adhesion energy were directing the efficacy of the encapsulated fungicide. The technology reported here can also be translated to a wide variety of industrial crops for fungal protection. The strength of this study is the possibility of using completely plant-derived, biodegradable/ compostable additive materials for controlled agrochemical delivery formulations, which will contribute to reducing the frequency of fungicide applications and the potential accumulation of formulation components in soil and water.

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“…Hydrolytic degradation of the formulation was studied in buffers of different pH (Ehsan et al 2022). The detailed protocol has been mentioned in Additional file 1.…”

Section: Hydrolytic Stability Studymentioning

confidence: 99%

ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation

Al Hoque,

Dutta,

Paul

et al. 2023

Cancer Nano

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Prostate cancer (PCa) is one of the fatal illnesses among males globally. PCa-treatment does not include radiotherapy. Chemotherapy eventually causes drug resistance, disease recurrence, metastatic advancement, multi-organ failure, and death. Preclinical data on PCa-induced by carcinogens are truly scarce. Although some data on xenograft-PCa in animals are available, they mostly belonged to immuno-compromised animals. Here, we developed ΔPSap4#5 aptamer surface-functionalized abiraterone-loaded biodegradable nanoparticle (Apt-ABR-NP) to investigate its targeting ability to prostate-specific membrane antigen (PSMA) in carcinogen-induced PCa mice and the therapeutic efficacy of the formulation. Aptamers are called synthetic monoclonal antibodies for their target specificity. However, they are devoid of the toxicity problem generally associated with the antibody. Abiraterone is a testosterone and androgen inhibitor, a new drug molecule that shows good therapeutic efficacy in PCa. The developed nanoparticles were physicochemically characterized and used for various in vitro and in vivo investigations. Nanoparticles had an average size of 149 nm with sustained drug release that followed Korsmeyer–Peppas kinetics. In vitro investigation showed that Apt-ABR-NP produced 87.4% apoptotic cells and 95.3% loss of mitochondrial membrane potential in LNCaP cells after 48 h of incubation. In vivo gamma scintigraphy, live imaging, and biodistribution studies in prostate cancer animal models showed the predominant targeting potential of Apt-ABR-NP. Histopathological investigation showed the remarkable therapeutic efficacy of the formulation. The pharmacokinetic study showed an increased biological half-life and enhanced blood residence time of Apt-ABR-NP. Apt-ABR-NP therapy can thus minimize off-target cytotoxicity, reduce drug loss due to site-specific delivery, and deliver abiraterone in a sustained manner to the organ of interest. Thus, the present study brings new hope for better therapeutic management of PCa in the near future. Graphical Abstract

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J591 functionalized paclitaxel-loaded PLGA nanoparticles successfully inhibited PSMA overexpressing LNCaP cells

Cited by 5 publications

References 52 publications

Formulation of Carnosic-Acid-Loaded Polymeric Nanoparticles: An Attempt to Endorse the Bioavailability and Anticancer Efficacy of Carnosic Acid against Triple-Negative Breast Cancer

Formulation of Carnosic-Acid-Loaded Polymeric Nanoparticles: An Attempt to Endorse the Bioavailability and Anticancer Efficacy of Carnosic Acid against Triple-Negative Breast Cancer

Biobased, Macro-, and Nanoscale Fungicide Delivery Approaches for Plant Fungi Control

ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation

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