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Abstract

Due to various advantages such as high-precision dosing, manufacturing efficiency and patient compliance helped making tablets the most popular dosage forms among all available dosages forms. Compaction, which is an essential manufacturing step in the manufacture of tablets, mainly includes compression (i.e. reduction of volume of the powder under consideration and particle rearrangement) and consolidation (i.e., formation of interparticulate bond to facilitate stable compaction). The success of the compaction process depends not only on the physico-technical properties of drugs and excipients, but also on the instrument settings with respect to rate and magnitude of force transfer. Tablet manufacturing speed and pre/main compression force profile also have an influence on the quality of the final tablet. Mechanical aspects of tablet formation can be studied using, instrumented punches/dies, instrumented tablet punching machines, and compaction simulators. These have potential application in pharmaceutical research and development, such as studying basic compaction mechanism, various process variables, scale-up parameters, trouble shooting problems, creating compaction data library, and fingerprinting of new active pharmaceutical ingredients (APIs) or excipients. Mathematical models, forcetime, force-distance, and die-wall force parameters of tablet manufacturing are used to describe work of compaction, elasticity/plasticity, and time dependent deformation behavior of pharmaceuticals powder under consideration.

Evaluation of the Ejection Pressure for Tracking Internal Cracks during Compaction in Bilayer Tablet Formulations Using Experimental and Finite Element Methods

“…Conversely, in the simulation, high stresses cated in red) are concentrated at the BLT interface's edge, where it contacts the d shown in the results, during main compression, the stress increased owing to the d pressure from the edge of the tablet in contact with the die. Thus, this stress dec intra-granular pores and increased plastic deformation at the edge of the BLT [43], m it difficult for air to become entrapped, thereby promoting a tight bond in the M layer. Similar to the stress distribution, the strain distribution results shown in Figu reveal severe strain around the edge of the BLT.…”

Exploring Excipients: Enhancing Solubility in Modified Drug Release Systems Using Inexpensive Tableting and Dissolution Methods

“…1 Solid drug dosage systems (SDDSs), of which tablets are the most popular choice, account for around 70−80% of drug delivery forms due to their ease of manufacture, convenience, cost, reliability, and patient compliance levels. 2 A majority of tablets are produced by direct compression of a powdered or granulated material held between two die faces, in a tableting machine capable of exerting high force. 3 Tablet design is a growing and evolving area in the creation of novel drug delivery systems (NDDSs), modified drug release systems (MDRSs), the development and application of active pharmaceutical ingredients (APIs), and the use of excipients.…”

“…Solid drug dosage systems (SDDSs), of which tablets are the most popular choice, account for around 70–80% of drug delivery forms due to their ease of manufacture, convenience, cost, reliability, and patient compliance levels . A majority of tablets are produced by direct compression of a powdered or granulated material held between two die faces, in a tableting machine capable of exerting high force .…”