JAK2/STAT3 inhibition attenuates intestinal ischemia–reperfusion injury via promoting autophagy: in vitro and in vivo study

Liu, Zhen; Hu, Kai; Chen, Yue-Sheng; Huang, Yingjie; Hu, Qian; Zeng, Wei; Cao, Yue; Qin, Xiao; Zhang, Xue-Kang

doi:10.1007/s11033-021-07099-x

Cited by 13 publications

(10 citation statements)

References 42 publications

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“…Research on autophagy in intestinal I/R shows multiple signaling pathways play a role. For instance, paeoniflorin activation of LKB1/AMPK pathway and mTOR signaling is positively correlated with, and the JAK2/STAT3 signaling pathway is negatively associated with the occurrence of autophagy ( 53 – 55 ). Some pathways may exhibit other effects while promoting autophagy.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and visual analysis of intestinal ischemia reperfusion from 2004 to 2022

et al. 2022

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BackgroundIntestinal ischemia/reperfusion (I/R) injury is a common tissue-organ damage occurring in surgical practice. This study aims to comprehensively review the collaboration and impact of countries, institutions, authors, subject areas, journals, keywords, and critical literature on intestinal I/R injury from a bibliometric perspective, and to assess the evolution of clustering of knowledge structures and identify hot trends and emerging topics.MethodsArticles and reviews related to intestinal I/R were retrieved through subject search from Web of Science Core Collection. Bibliometric analyses were conducted on Excel 365, CiteSpace, VOSviewer, and Bibliometrix (R-Tool of R-Studio).ResultsA total of 1069 articles and reviews were included from 2004 to 2022. The number of articles on intestinal I/R injury gradually plateaued, but the number of citations increased. These publications were mainly from 985 institutions in 46 countries, led by China and the United States. Liu Kx published the most papers, while Chiu Cj had the largest number of co-citations. Analysis of the journals with the most outputs showed that most journals focused on surgical sciences, cell biology, and immunology. Macroscopic sketch and microscopic characterization of the entire knowledge domain were achieved through co-citation analysis. The roles of cell death, exosomes, intestinal flora, and anesthetics in intestinal I/R injury are the current and developing research focuses. The keywords “dexmedetomidine”, “proliferation”, and “ferroptosis” may also become new trends and focus of future research.ConclusionThis study comprehensively reviews the research on intestinal I/R injury using bibliometric and visualization methods, and will help scholars better understand the dynamic evolution of intestinal I/R injury and provide directions for future research.

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Section: Discussionmentioning

confidence: 99%

Bibliometric and visual analysis of intestinal ischemia reperfusion from 2004 to 2022

et al. 2022

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“…In our literature search, 15 studies made use of transcriptomics technology to study intestinal IR injury versus sham surgery in animals [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] (Table 1, part I). The aims of these studies ranged from exploring overall changes in gene expression in intestinal IR for a better understanding of the pathological process and/or to identify potential therapeutic targets [10,16,17,21], to specific testing of a therapeutic intervention [11,13,15,18,19], or both [12,14,23,24]. For these studies, mice were most commonly used to establish an intestinal IR model [11,13,[15][16][17][18][19]21], and two studies made use of rats [10,14].…”

Section: Transcriptomicsmentioning

confidence: 99%

Unveiling the molecular complexity of intestinal ischemia–reperfusion injury through omics technologies

Alicehajic,

Duivenvoorden,

Lenaerts

2024

Proteomics

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Intestinal ischemia–reperfusion injury (IR) is implicated in various clinical conditions and causes damage to the intestinal epithelium resulting in intestinal barrier loss. This presents a substantial clinical challenge, emphasizing the importance of gaining a comprehensive understanding of molecular events to aid in the identification of novel therapeutic targets. This review systematically explores the extent to which omics technologies—transcriptomics, proteomics, metabolomics, and metagenomics—have already contributed to deciphering the molecular mechanisms contributing to intestinal IR injury, in in vivo and in vitro animal and human models, and in clinical samples. Recent breakthroughs involve applying omics methodologies on exosomes, organoids, and single cells, shedding light on promising avenues and valuable targets to reduce intestinal IR injury. Future directions aimed at expediting clinical translation are discussed as well and include multi‐omics data integration to facilitate the identification of key regulatory nodes driving intestinal IR injury and advancing human organoid models based on the novel insights by single‐cell omics technologies, offering hope for clinical application of therapeutic strategies in the years to come.

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“…increases, and the corresponding signaling pathways are activated, which further recruits neutrophils and aggravates the inflammatory response (53). Liu et al (54) systematically analyzed gut transcriptome data and found that IR significantly activated the JAK2-STAT pathway, with the most significant upregulation of JAK2 and STAT3. Finally, it is concluded that the JAK2/STAT3 signaling pathway can inhibit autophagy during intestinal IR to protect against intestinal IR injury.…”

Section: Mechanisms Of Iirmentioning

confidence: 99%

Effects of Hyperbaric Oxygen Therapy on Intestinal Ischemia-Reperfusion and Its Mechanism

Song,

Li,

et al. 2023

Shock

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Ischemia can cause reversible or irreversible cell or tissue damage, and reperfusion after ischemia not only has no therapeutic effect, but also aggravates cell damage. Notably, gut tissue is highly susceptible to ischemia-reperfusion injury under many adverse health conditions. Intestinal ischemia-reperfusion (IIR) is an important pathophysiological process in critical clinical diseases. Therefore, it is necessary to identify better therapeutic methods for relieving intestinal ischemia and hypoxia. Hyperbaric oxygenation (HBO) refers to the intermittent inhalation of 100% oxygen in an environment greater than 1 atmosphere pressure, which can better increase the oxygen level in the tissue, and change the inflammatory pathway. Currently, it can have a positive effect on hypoxia and ischemic diseases. Related studies have suggested that hyperbaric oxygen can significantly reduce ischemia-hypoxic injury to the brain, spinal cord, kidney and myocardium. This paper reviews the pathogenesis of ischemia-reperfusion and the current treatment measures, and further points out that hyperbaric oxygen has a better effect in ischemia-reperfusion. We found that not only improved hypoxia, but also regulated ischemia-reperfusion-induced injury in a certain way. From the perspective of clinical application, these changes and the application of hyperbaric oxygen therapyhave important implications for treatment, especially intestinal ischemia-reperfusion.

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JAK2/STAT3 inhibition attenuates intestinal ischemia–reperfusion injury via promoting autophagy: in vitro and in vivo study

Cited by 13 publications

References 42 publications

Bibliometric and visual analysis of intestinal ischemia reperfusion from 2004 to 2022

Bibliometric and visual analysis of intestinal ischemia reperfusion from 2004 to 2022

Unveiling the molecular complexity of intestinal ischemia–reperfusion injury through omics technologies

Effects of Hyperbaric Oxygen Therapy on Intestinal Ischemia-Reperfusion and Its Mechanism

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