Japanese summer‐type hypersensitivity pneumonitis: studies using <i>Cryptococcus</i> antigen

Miyagawa, Toshi; Hamagami, Sayo; Ochi, Tadao; Osugi, Takashi; Kikui, Masanori; Takahashi, H.

doi:10.1111/j.1365-2222.1982.tb02538.x

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…One is that this species is often found in the air as first reported by Saito in 1922 (32). The other is that whether this species would be one of the causative agents of Japanese summertype hypersensitivity pneumonitis firstly reported by Miyagawa et al (29), because Shimazu et al reported that one of the causative agents of the disease is Trichosporon cutaneum (33), and also we found that there was serologic cross-reactivity among C. neoformans A, C. albidus (21) and T. cutaneum.…”

Section: R Ikei)asupporting

confidence: 57%

Comparison of Serological and Chemical Characteristics of Capsular Polysaccharides of Cryptococcus neoformans var. neoformans Serotype A and Cryptococcus albidus var. albidus

Ikeda

Matsuyama

Nishikawa

et al. 1991

Microbiology and Immunology

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The antigenic formula and chemical structure of capsular polysaccharide (CPS) of Cryptococcus albidus var. albidus (C. albidus) were studied in relation to those of C. neoformans var. neoformans serotype A (C. neoformans A). The results of slide agglutination tests with factor sera and reciprocal adsorption experiments showed that antigenic formula of C. albidus was the same as that of C. neoformans A. The soluble CPSs from the two species were obtained from culture supernatants by precipitation with ethanol followed by purification by chromatography on DEAE-cellulose column. The structural analyses of such CPSs from the two species showed that the antigenic CPS fractions consisted of a backbone of a(1-3)-linked D-mannopyranosyl residues with a single branch of P(1-2)-xylose or glucuronic acid, and mostly with O-acetyl groups, in which side chains and O-acetyl groups were responsible for antigenic specificity. It was found that there was a minor difference between the CPS of C. neoformans A and that of C. albidus; in the former, unsubstituted mannose residues existed in a low frequency, but in the latter none. Moreover, the 1H-nuclear magnetic resonance spectra of partially hydrolyzed acidic fragments of the two CPSs indicated that two xylose side chains were present between glucuronic acid side chains. Taken together, it was suggested that these two species of C. neoformans A and C. albidus are closely related to each other in their CPSs.

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Section: R Ikei)asupporting

confidence: 57%

Comparison of Serological and Chemical Characteristics of Capsular Polysaccharides of Cryptococcus neoformans var. neoformans Serotype A and Cryptococcus albidus var. albidus

Ikeda

Matsuyama

Nishikawa

et al. 1991

Microbiology and Immunology

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“…The actual extent of subclinical exposure is unknown because an adequate skin test antigen has not been developed for population surveys. However, limited serological studies indicate that most healthy individuals possess antibodies to C. neoformans (23,231,323).…”

Section: Ecology Sexual Reproduction and Identificationmentioning

confidence: 99%

Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans

1995

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Although Cryptococcus neoformans and cryptococcosis have existed for several millennia, a century has passed since the discovery of this encapsulated yeast and its devastating disease. With the advent of the AIDS pandemic, cryptococcal meningitis has emerged as a leading cause of infectious morbidity and mortality and a frequently life-threatening opportunistic mycosis among patients with AIDS. Both basic and clinical research have accelerated in the 1990s, and this review attempts to highlight some of these advances. The discussion covers recent findings, current concepts, controversies, and unresolved issues related to the ecology and genetics of C. neoformans; the surface structure of the yeast; and the mechanisms of host defense. Regarding cell-mediated immunity, CD4+ T cells are crucial for successful resistance, but CD8+ T cells may also participate significantly in the cytokine-mediated activation of anticryptococcal effector cells. In addition to cell-mediated immunity, monoclonal antibodies to the major capsular polysaccharide, the glucuronoxylomannan, offer some protection in murine models of cryptococcosis. Clinical concepts are presented that relate to the distinctive features of cryptococcosis in patients with AIDS and the diagnosis, treatment, and prevention of cryptococcosis in AIDS patients.

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“…They identified T cutaneum as the agent by isolation from the environment of SHP patients. The disease was originally described by Miyagawa et al (11). They reported that SHP patients' sera contained an antibody which reacted with the Cryptococcus species.…”

mentioning

confidence: 99%

Serological Characterization of Trichosporon cutaneum and Related Species

Ikeda

Yokota

Saitô

1996

Microbiology and Immunology

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Recent molecular biological, chemical, physiological and morphological studies indicate that Tri-chosporon cutaneum and related species should be reclassified. In this study, antigenic characteristics of the species were determined. The results of adsorption experiments revealed that there were at least three serological types: I, II and III. Specific factor sera I, II and III were prepared on the basis of adsorption experiments and isolates were serotyped by cell slide agglutination (CSA). Since the CSA test was difficult to read in some strains, the results of the CSA test were compared with the findings from an enzyme-linked immunosorbent assay (ELISA). For the ELISA, crude polysaccharide antigens prepared from the culture supernatant were used as the antigen. The types determined by ELISA correlated well with those determined by the CSA test. These data suggest that T. cutaneum and related species have at least three serological types, and that the typing can be done by either CSA or ELISA.

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Japanese summer‐type hypersensitivity pneumonitis: studies using Cryptococcus antigen

Cited by 13 publications

References 17 publications

Comparison of Serological and Chemical Characteristics of Capsular Polysaccharides of Cryptococcus neoformans var. neoformans Serotype A and Cryptococcus albidus var. albidus

Comparison of Serological and Chemical Characteristics of Capsular Polysaccharides of Cryptococcus neoformans var. neoformans Serotype A and Cryptococcus albidus var. albidus

Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans

Serological Characterization of Trichosporon cutaneum and Related Species

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