Japanese version of the <scp>Montreal Cognitive Assessment</scp> cut‐off score to clarify improvement of mild cognitive impairment after exercise training in community‐dwelling older adults

Nara, Marina; Sugie, Masamitsu; Takahashi, Toshio; Koyama, Takeo; Sengoku, Renpei; Fujiwara, Yoshinori; Obuchi, Shuichi; Harada, Kazumasa; Kyo, Shunei; Ito, Hideki

doi:10.1111/ggi.13253

Cited by 24 publications

(20 citation statements)

References 17 publications

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“…The MoCA cutoff scores of ischemic stroke patients by the educational level have been reported as follows: 24/25 for individuals with ≥7 years of education, 19/20 for individuals with 1 to 6 years of education, and 13/14 for illiterate individuals. Therefore, we also used a cutoff point of 22/23 (which we used as Method 2 in our study) for MoCA scores [ 24 , 31 , 37 ].…”

Section: Methodsmentioning

confidence: 99%

Synergistic Effects of Aldehyde Dehydrogenase 2 Polymorphisms and Alcohol Consumption on Cognitive Impairment after Ischemic Stroke in Han Chinese

Gao

Wang

et al. 2021

Behavioural Neurology

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Aldehyde dehydrogenase 2 (ALDH2) polymorphisms are related to both stroke risk and alcohol consumption. However, the influence of ALDH2 polymorphisms and alcohol consumption on cognitive impairment after ischemic stroke remains unknown, as do the possible mechanisms. We enrolled 180 Han Chinese ischemic stroke patients from four community health centers in Bengbu, China. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), and two different MoCA cutoff scores were used to define cognitive impairment in ischemic stroke patients. The ALDH2 genotypes were determined using polymerase chain reaction and direct sequencing. To assess the associations of ALDH2 polymorphisms and alcohol consumption with cognitive impairment after ischemic stroke, we performed binary logistic regression analysis with odds ratios. We revealed that individuals with the ALDH2 wild-type genotype were more likely to have high MoCA scores than those with the mutant and heterozygous types ( p = 0.034 ). In addition, using two MoCA cutoff scores, the percentage of moderate to excessive alcohol consumption in the cognitive impairment group was higher than that in the nonimpairment group ( p = 0.001 ). The levels of 4-hydroxy-2-nonenal ( p = 0.001 ) and swallowing function ( p = 0.001 ) were also higher in the cognitive impairment group than in the nonimpairment group. Moreover, after adjusting for other potential risk factors, ALDH2 polymorphisms and alcohol consumption had a significant synergistic effect on cognitive impairment ( p = 0.022 ). Specifically, the ALDH2 ∗ 2 mutant allele and higher alcohol consumption were associated with cognitive impairment and swallowing ability after ischemic stroke. Targeting ALDH2 may be a useful biomarker for cognitive rehabilitation following ischemic stroke.

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Section: Methodsmentioning

confidence: 99%

Synergistic Effects of Aldehyde Dehydrogenase 2 Polymorphisms and Alcohol Consumption on Cognitive Impairment after Ischemic Stroke in Han Chinese

Gao

Wang

et al. 2021

Behavioural Neurology

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“…Finally, exercise tolerance was assessed using cardiopulmonary exercise testing. All of these assessments were evaluated as previously described 10,14–17 …”

Section: Methodsmentioning

confidence: 99%

Effectiveness of a far‐infrared low‐temperature sauna program on geriatric syndrome and frailty in community‐dwelling older people

Sugie

Harada

Takahashi

et al. 2020

Geriatrics Gerontology Int

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Aim: Although it is known that geriatric syndrome is associated with the development of frailty, it is not known whether an amelioration of geriatric syndrome also improves shared risk factors and frailty. Methods: In total, 67 community-dwelling older people (79.6 AE 6.5 years, 49 women) participated in this study (41 were classified as pre-frail and 26 as frail). We analyzed indices of physical frailty and cognitive depression, exercise tolerance and health-related quality of life as frailty related indices, and the participants completed a questionnaire regarding common geriatric symptoms (cold extremities, leg edema, breathlessness, urinary incontinence, chronic headache, chronic pain, a sense of numbness, anorexia, constipation, insomnia and skin trouble) using numeric ratings. Frailty was evaluated using the Japanese version of the Cardiovascular Health Study (J-CHS) criteria. The participants then underwent a far-infrared low-temperature sauna (FILTS) program twice a week for 3 months and the above parameters were reassessed. Results: After the FILTS program, there were significant differences in usual walking speed, peak oxygen uptake, Geriatric Depression Scale-15, health-related quality of life and the severity of several geriatric symptoms. Of the 67 participants, 18 showed improvements in their J-CHS frailty score, 47 showed no change and two showed reductions. Linear regression analysis showed that the change in the numeric rating of the coldness of extremities (B = −0.105, P = 0.013) and the cumulative numeric rating for geriatric syndromes (B = 0.044, P < 0.001) were independent determinants of the change in the J-CHS score. Conclusions: A 3-month FILTS program ameliorates geriatric syndrome, the severity of frailty and frailty related indices in older Japanese people.

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“…The patients were classified as cognitively impaired (<20 points) or not cognitively impaired (≥20 points) [20]. In addition, mild cognitive impairment (MCI) was defined as scoring 23 points or less [21].…”

Section: Assessment Of Cognitive Functionmentioning

confidence: 99%

Reference Values and Correlations for Multiple Physical Performance Measures: A Cross-Sectional Study among Independently Mobile Older Men in Japan

Ishii¹,

Noguchi²,

Sato³

et al. 2020

IJERPH

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Purpose: Japan is one of few countries with a male life expectancy over 80 years. The gap between the healthy life span and the total life expectancy is large, highlighting the importance of maintaining physical performance. The present study aims to establish reference values for multiple physical performance measures among high-functioning oldest-old Japanese men and to investigate the correlations among these measurements to understand how these variables are related. Methods: This study was conducted with 120 Japanese males aged 80 years or older who were able to walk independently. Seven measures of physical performance were assessed: handgrip strength, quadriceps strength, static balance ability (one-legged stance), dynamic balance ability (Functional Reach Test; FRT), walking ability (5-m walking time test), combined movement ability (Timed Up & Go test), and bone quality. Cognitive function was also measured (Mini-Mental State Examination; MMSE). Results: Specific reference values are reported for each physical performance measurement explored in this study. Only six participants were classified as cognitively impaired, and 16 had mild cognitive impairment. There were significant correlations of varying levels among all of the measures of physical performance. Age was significantly correlated with all performance measures except FRT, and there was no correlation between age and MMSE. MMSE was weakly correlated with FRT and unrelated to the other performance measures. Conclusions: The reference ranges can be used by older men who have not yet reached 80 years and their health care providers as physical performance targets to facilitate the maintenance of independent mobility in later life.

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Japanese version of the Montreal Cognitive Assessment cut‐off score to clarify improvement of mild cognitive impairment after exercise training in community‐dwelling older adults

Cited by 24 publications

References 17 publications

Synergistic Effects of Aldehyde Dehydrogenase 2 Polymorphisms and Alcohol Consumption on Cognitive Impairment after Ischemic Stroke in Han Chinese

Synergistic Effects of Aldehyde Dehydrogenase 2 Polymorphisms and Alcohol Consumption on Cognitive Impairment after Ischemic Stroke in Han Chinese

Effectiveness of a far‐infrared low‐temperature sauna program on geriatric syndrome and frailty in community‐dwelling older people

Reference Values and Correlations for Multiple Physical Performance Measures: A Cross-Sectional Study among Independently Mobile Older Men in Japan

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