Jatropha Curcas Linn can Reduce the Expression of Hsp70 that will Result in Reduced Errors in Protein Folding and Promotion of Normal Protein Function in Proliferation and Apoptosis

Abstract

Background: Jatropha curcas (J. curcas) as a local plant have phytochemical contents like phenolic that effect as anti-inflammatory and cytotoxicity properties. Research in the last decade about cancers showed that over expression of heat shock protein 70 (Hsp70) does to mis-folding and continues to triggering proliferation and suppressing apoptosis. Increased expression of Hsp70 is responsible for mis-folding of proteins and implicated in functions that lead and play a role in the pathogenesis of pain including cancer incidence. In this study, we examined the expression of Hsp70, pRb and caspase3 in Raji cells after treatment with J. curcas.