Jaundice: a basic review

Abbas, Muhammad Waseem; Shamshad, Talha; Ashraf, Muhammad Aizaz; Javaid, Rukhsar

doi:10.18203/2320-6012.ijrms20161196

Cited by 29 publications

(21 citation statements)

References 30 publications

(37 reference statements)

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“…It is known that patients with HLH may present jaundice, 1,4,26 hence corroborating our findings since both patients were icteric. Jaundice occurs due to the impregnation of bilirubin in different tissues in consequence of hyperbilirubinemia, 27 which was also observed in both patients of the present Patients with HLH may have poor prognostic factors, such as neurological changes, renal disorders, hepatic failure, or hemorrhagic diathesis. 4,22,37 In our study, P1 had neurological changes and renal dysfunction (acute tubular necrosis).…”

Section: Analysis Of the Organs By Autopsy Of P2supporting

confidence: 65%

Hemophagocytic Lymphohistiocytosis in Autopsied Adults: Clinical, Laboratory and Immunohistochemical Evaluation for CD68 and CD57. Case Report and Literature Review

et al. 2019

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Hemophagocytic lymphohistiocytosis (HLH) is a rare, usually fatal and underdiagnosed autoimmune-activated disease. The present study aimed to perform a macroscopic, histopathological and immunohistochemical evaluation for CD68 and CD57 in organs of autopsied adults with HLH. A total of 604 autopsy reports were analyzed, and all the patients that filled the diagnostic criteria for HLH (n = 2) were selected. These patients were 18 and 37 years old. Were evaluated both clinical and autopsy reports and performed histopathological and immunohistochemical analysis of the liver and spleen. Both patients filled the diagnostic criteria for HLH, as well as presented common signs and symptoms of this disease, such as chills, abdominal pain, diaphoresis, and jaundice. Hemophagocytosis was observed in the spleen, bone marrow, and lymph nodes of the two patients at autopsy. Immunostaining in the liver and spleen of both patients was mainly severe for CD68, and predominantly mild for CD57, indicating a decrease in NKC numbers and an increase in the number of macrophages, respectively. This was the first study to evaluate CD57 and CD68 in autopsies of adults with HLH. Thus, more studies are required, not only to better elucidate the pathogenetic mechanisms involved in the secondary HLH, but also to disseminate the results in the clinical environment, contributing to the early diagnosis and treatment with consequent reduction of mortality rate. Keywords: Autoimmune Diseases. Histiocytosis. Biomarkers. ResumoA Linfohistiocitose Hemofagocítica (HLH) é uma doença autoimune rara, geralmente fatal e subdiagnosticada. Este estudo tem como objetivo realizar avaliação macroscópica, histopatológica e imunohistoquímica para CD68 e CD57 em órgãos de pacientes adultos com HLH submetidos a autópsia. Um total de 604 laudos de autópsias foram analisados e todos os pacientes que preencheram os critérios diagnósticos para HLH (n = 2) foram selecionados. Esses pacientes tinham 18 e 37 anos de idade. Foram analisados tanto os prontuários quanto os laudos de autópsia, bem como foram realizadas análises histopatológicas e imunohistoquímicas do fígado e baço dos pacientes. Ambos preencheram os critérios diagnósticos para HLH e apresentarem sinais e sintomas comuns da doença, como calafrios, dor abdominal, sudorese e icterícia. A hemofagocitose foi observada no baço, medula óssea e linfonodos dos dois pacientes na autópsia. A imunohistoquímica do fígado e do baço de ambos os pacientes demonstrou imunomarcação acentuada para CD68 e predominantemente discreta para CD57, que indicam diminuição do número de NKC e aumento do número de macrófagos, respectivamente. Este foi o primeiro estudo a avaliar o CD57 e CD68 em autópsias de adultos com HLH. Assim, mais estudos são necessários, não apenas para melhor elucidar os mecanismos patogenéticos envolvidos na HLH secundária, mas também para disseminar os resultados no ambiente clínico, contribuindo para o diagnóstico e tratamento precoces com consequente redução da taxa de mortalidade. Palavras-chave: Doenças Autoimunes. Histiocitose. Biomarcadores.

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Section: Analysis Of the Organs By Autopsy Of P2supporting

confidence: 65%

Hemophagocytic Lymphohistiocytosis in Autopsied Adults: Clinical, Laboratory and Immunohistochemical Evaluation for CD68 and CD57. Case Report and Literature Review

et al. 2019

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“…The word jaundice is a derivative of French word 'Jaune' that means 'yellow' . The causes of jaundice are either acquired or congenital 13 . Jaundice is a symptom rather than a disease.…”

Section: Introductionmentioning

confidence: 99%

An Ethnobotanical Study of Medicinal Plants used against Jaundice by Tea Tribes of Morigaon District, Assam (India)

Bhattacharyya¹,

Medhi²,

Borthakur

et al. 2020

Journal of Natural Remedies

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The present study was conducted to document the ethnomedicinal plants used against jaundice by the tea tribes of Morigaon district of Assam, India. An ethnomedicinal field study was carried out from June 2016-July 2017. Information was gathered by using a semi-structured questionnaire about the traditional knowledge of medicinal plants used against jaundice by the tea tribes of Morigaon district of Assam. Documented data was evaluated using the quantitative ethno-botanical indices of fidelity level (FL), Use Value (UV) and Family Use Value (FUV). From the ethno-botanical investigation, a total of 39 species of plants covering 36 genera and 27 families respectively have been enumerated. A total of 53 informants aged from 20-75 years were interviewed to record the ethnomedicinal data. Lamiaceae was the dominant family. Among the plant portions, leaves were most frequently used. Among the 39 medicinal plant species recognized mostly were herbs. The plants species having the highest use value were Drymaria cordata trailed by Xylosma longifolia and Achyranthes aspera, Aegle marmelos, Alstonia scholaris and Justicia gendarussa. The fidelity level was 100% for Achyranthes aspera, Cheilocostus speciosus, Clerodendrum infortunatum, Justicia gendarussa, Lawsonia inermis, Coffea benghalensis and Saccharum officinarum. The tea tribes of Morigaon district still relies on herbal therapies for curing jaundice. Coffea benghalensis has not been previously reported as a remedy of jaundice from Northeast India. Further research is needed to investigate the phytochemistry and pharmacological effectiveness of the plant species that could be the basis for the isolation and development of some novel phyto-therapeutic active compounds in the future.

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“…Jaundice is actually the high bilirubin level in the body. The causes of various variants of jaundice is either acquired or congenital (Abbas et al 2016, Dutta et al 2013. Rahman et al (2014) conducted a study in Mirpur area and observed that occurrence of jaundice was the lowest among the people aged 18 -30 (27.6%), rising more or less steadily with age peaking at 52.9% among those above 60 years old.…”

Section: Resultsmentioning

confidence: 99%

Occurrence of common diseases among the staff of three residential halls of University of Dhaka

Zaman

Khanum

Mukutmoni

et al. 2018

Bangladesh J. Zool.

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Abstract:A cross-sectional study was conducted to know the occurrence of common diseases in staff and their family members in three residential halls of University of Dhaka. The individuals were interviewed about the diseases they encountered recently. Among 270 respondents, the highest occurrence of diarrhea (44.44%) was recorded among 16-30 years old staff of Dr. Muhammad Shahidullah hall. Peak occurrence of sinusitis (37.25%) was observed among the staff aged 31-45 years old of the same hall. The highest occurrence of eczema (37.5%) was observed among the staff aged 46-60 years old of Amar Ekushey hall. Diarrhoea was prevalent among the groups who preferred food from hotel comprising the highest prevalence (72.73%) in Dr. Muhammad Shahidullah hall (p = 5.024). The uppermost occurrence of jaundice was recorded among the staff of Fazlul Huq Muslim hall who used to take food from outside hotels (71.43%).

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Jaundice: a basic review

Cited by 29 publications

References 30 publications

Hemophagocytic Lymphohistiocytosis in Autopsied Adults: Clinical, Laboratory and Immunohistochemical Evaluation for CD68 and CD57. Case Report and Literature Review

Hemophagocytic Lymphohistiocytosis in Autopsied Adults: Clinical, Laboratory and Immunohistochemical Evaluation for CD68 and CD57. Case Report and Literature Review

An Ethnobotanical Study of Medicinal Plants used against Jaundice by Tea Tribes of Morigaon District, Assam (India)

Occurrence of common diseases among the staff of three residential halls of University of Dhaka

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