Jaundice Associated With Norethisterone-Acetate Treatment of Breast Cancer

Langlands, A.O.; Martin, W.M.C.

doi:10.1016/s0140-6736(75)91617-7

Cited by 8 publications

(2 citation statements)

References 3 publications

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“…1 Intrahepatic cholestatic jaundice is well known and is due to estrogenic component of combined oral contraceptive medications. [2][3][4] Multiple case reports of oral contraceptive induced liver injury have been described in the literature. [2][3][4][5] Progestogens are usually not implicated in the process of cholestasis.…”

Section: Discussionmentioning

confidence: 99%

Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases

Choudhary

Bodh

Chaudhari

et al. 2017

Journal of Clinical and Experimental Hepatology

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Drug induced liver injury (DILI) is uncommon and severe forms are associated with significant morbidity and mortality. Female sex hormones (estrogens and progestogens) related DILI generally occur with estrogen component. Progesterone component related DILI are infrequently reported. Norethisterone is commonly used drug in gynecologic practice to prevent excess per vaginal bleeding. We report 3 cases of Norethisterone related DILI manifesting as significant rise of transaminases. All of these patients took Norethisterone for prolonged periods and improved completely after withdrawal of drug.

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Section: Discussionmentioning

confidence: 99%

Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases

Choudhary

Bodh

Chaudhari

et al. 2017

Journal of Clinical and Experimental Hepatology

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“…Thus, even though there have been no reports of possible liver damage from OCs containing only low doses of gestagens, i.e. doses lower than those of the preparations considered in this report, there have been reports of cholestatic liver reactions from high-dose gestagen preparations (10 mg norethisterone acetate 3 4 times day-') in the treatment of breast cancer [20].…”

Section: Discussionmentioning

confidence: 78%