Jaundice During Pregnancy

Rencoret, R; Aste, H.

doi:10.1097/00006254-197308000-00006

Cited by 9 publications

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“…This was higher than that observed in other countries where the prematurity rate was 33% to 36%. 28,29 Only six of our patients (12%) had jaundice, as in another study. 10 The greater frequency of jaundice in some studies This might have been related to the high rate of multiple pregnancies in our series (18%).…”

Section: Progesterone Intake In Control Population Of Pregnant Womensupporting

confidence: 68%

Intrahepatic cholestasis of pregnancy: A French prospective study

et al. 1997

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The prevalence of ICP varies greatly according to country. The aim of this prospective study was to analyze the charac-The prevalence is high in Scandinavian countries (1%-teristics of intrahepatic cholestasis of pregnancy (ICP) in a 1.5%), 3,4 in Bolivia (9.2%), 5 and in Chile, with a prevalence French population. From 1989 to 1995 we studied 50 consecof between 11.8% and 27.6% according to ethnic origin. 6 In utive pregnant women with ICP (41 single, 7 twin, and 2Santiago the prevalence of ICP was recently evaluated at 4%. 7 triplet pregnancies) referred for hepatologic consultation. All In contrast, the prevalence is reported to be low in the United patients suffered from pruritus and/or jaundice associated States, 8 Canada, 9 and Switzerland. 10 In France the prevalence with elevated fasting serum levels of total bile acids (mean has been assessed to be 0.2% to 0.5% 11,12 and ICP has not 49 mmol/L, range 7-290). No patients had concomitant liver often been studied. disease and all recovered normal liver function after delivery.The aim of this prospective study was to analyze characterOverall prematurity rate was 60%: 100% in multiple pregnanistics of ICP in France. rently treated with cholestyramine), after decrease in dose ofSigns of pre-eclampsia, fever, and urinary or endocervical infection progesterone in 1 patient, and spontaneously in 2 patients.were exclusion criteria. In cases of recurrent ICP the first occurrence During the same period, the percentage of pregnant women during the period under study was taken into account for the dewithout ICP who had been treated with progesterone during scription of characteristics. pregnancy was statistically lower than the percentage of patients treated with progesterone before the onset of pruritus Methods in our group of patients with ICP (36% vs. 64%, P õ .01, Biological Tests. Fasting blood samples were taken and serum TBA odds ratio 3.16, 95% CI:1.29-7.80). These results suggest that and total bilirubin and conjugated bilirubin concentrations, and orally administered progesterone might be an exogenous fac-serum ALT, alkaline phosphatase (AP), and g-glutamyl transpeptitor which triggers ICP in predisposed women. (HEPATOLOGY dase (GGT) activity, were measured at least twice, for each patient. 1997;26:358-364.)In fact, this was usually once or twice a week until delivery. Serum aspartate aminotransferase (AST) and 5 nucleotidase activity was measured in 19 and 44 patients, respectively. Prothrombin time, Intrahepatic cholestasis of pregnancy (ICP) is a liver discreatininemia, and uricemia were also regularly monitored. For each ease unique to pregnancy, which occurs in the second or patient, the most abnormal values, i.e., the highest values for LFTs, third trimesters and disappears spontaneously after delivery. uricemia, creatininemia, and the lowest values for prothrombin timeThe occurrence of ICP carries a risk for the fetus and pruritus were retained for the calculation of the biological characteristics. is a very uncomfortable symptom for the mother. ...

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Section: Progesterone Intake In Control Population Of Pregnant Womensupporting

confidence: 68%

Intrahepatic cholestasis of pregnancy: A French prospective study

et al. 1997

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“…37,38 Although maternal complications from ICP are rare, there are several adverse fetal effects including preterm labor, meconium aspiration, and fetal death. [37][38][39][40] Rencoret and Aste 37 reviewed 32 cases of jaundice in pregnancy (31 out of 32 cases with intrahepatic cholestasis) and reported two fetal deaths and a preterm labor rate of 33.3%. Reid and colleagues 38 analyzed complications in 56 pregnancies with ICP and reported an astonishingly high rate of adverse outcomes (ie, perinatal mortality rate 11%, meconium staining 27%, abnormal antepartum fetal heart rate pattern 14%, and preterm delivery rate 36%).…”

Section: Impact On the Fetusmentioning

confidence: 99%

Cholestasis of Pregnancy

Pathak

Sheibani

Lee

2010

Obstetrics and Gynecology Clinics of North America

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“…T h e severity of the maternal illness is the major determining factor in maternal and perinatal deaths. Other investigators lntj Gynaecol Obstet 16 (4,16,19,21) have shown a similar increased incidence of spontaneous termination of pregnancy and fetal wastage in women with hepatitis.…”

Section: Discussionmentioning

confidence: 68%

Jaundice During Pregnancy in Ibadan, Nigeria

Ogunbode

1979

Intl J Gynecology & Obste

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The clinical features of hepatitis during pregnancy and the effect of this complication on the mother and the fetus were evaluated in 45 patients with jaundice who were treated at the University College Hospital, Ibadan, Nigeria, from July 1976 to January 1978. Viral hepatitis was the cause of jaundice in 23 of the 45 patients in this prospective study. Three of these patients had the fulminant type of jaundice which resulted in maternal deaths. The peak incidence of the disease occurred in the last trimester. Hepatitis had a deleterious effect on the outcome of pregnancy; the effect was directly related to the severity of the disease, especially when associated with pyrexia. It is postulated that, by lowering resistance to infection, malnutrition may play a significant role in the pathogenesis of hepatitis during pregnancy.

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Jaundice During Pregnancy

Cited by 9 publications

References 0 publications

Intrahepatic cholestasis of pregnancy: A French prospective study

Intrahepatic cholestasis of pregnancy: A French prospective study

Cholestasis of Pregnancy

Jaundice During Pregnancy in Ibadan, Nigeria

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