Jaundice In Dog Associated With Babesiosis

Yadav, Rajendra; Gattani, Anil; Gupta, S. R.; Sharma, C. S.

doi:10.5455/ijavms.20110206071738

Cited by 4 publications

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“…[ 18 ] and Yadav et al . [ 19 ]. The respiration rate, heart rate, and capillary refilling time were increased than healthy dogs may be due to marked anemia and stress [ 18 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

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Clinicopathological alterations in naturally occurring Babesia gibsoni infection in dogs of Middle-South Gujarat, India

2017

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Aim:The present research work was undertaken to describe various clinical signs and hematobiochemical alterations in dogs affected with Babesia gibsoni.Materials and Methods:Blood smears from a total of 79 suspected dogs of Anand region as well as Surat region of Gujarat state (India) were screened for detection of intraerythrocytic piroplasm of small form of Babesia. Diagnosis was made on the basis of clinical signs and demonstration of B. gibsoni organism in Giemsa-stained thin blood smears. The clinical signs were recorded at the time of presentation, and blood samples were subjected to estimation of hematobiochemical parameters by auto hematology analyzers at College of Veterinary Science and Animal Husbandry, Anand. Statistical analysis, interpretation, and comparison of hematobiochemical changes with scientific literature were carried out to understand the pathophysiology of the disease.Results:Out of 79 dogs, 16 were positive for naturally occurring babesiosis based on the presence of intraerythrocytic piroplasm of small form of Babesia in blood smears. The clinical cases were manifested by wide variety of non-specific clinical signs. The hematological evaluation revealed that the mean values of hemoglobin and total erythrocyte counts in dogs with babesiosis decreased significantly (p<0.01) in comparison to healthy dogs. Among differential leukocyte count, mean values of neutrophils and eosinophils increased while lymphocytes decreased (p<0.01) in dogs with babesiosis in comparison to healthy dogs. Serum biochemistry revealed increase (p<0.01) value of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, and globulin as well as decrease in albumin levels (p<0.05) in dogs with babesiosis as compared to healthy dogs.Conclusion:B. gibsoni is having multisystemic effects with atypical hematobiochemical changes in dog are discussed here, which would aid new insights in diagnosis of disease.

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“…[ 18 ] and Yadav et al . [ 19 ]. The respiration rate, heart rate, and capillary refilling time were increased than healthy dogs may be due to marked anemia and stress [ 18 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…[ 22 ] and Yadav et al . [ 19 ]. Pale mucous membranes were due to marked anemia and petechiation was due to intravascular hemolysis.…”

Section: Resultsmentioning

confidence: 99%

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Clinicopathological alterations in naturally occurring Babesia gibsoni infection in dogs of Middle-South Gujarat, India

2017

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“…In general, significantly decreased concentrations of albumin were found by Yadav et al 33 and Vijayalakshmi et al 34 in dogs with babesiosis than in healthy dogs. Yogeshpriya et al 30 observed no marked differences in the albumin concentrations between dogs naturally infected with B. gibsoni and healthy dogs.…”

Section: Discussionmentioning

confidence: 81%

“…The above mentioned changes in the concentrations of protein fractions resulted also in alterations in the A/G ratio. Decreased A/G ratio was found in dogs with babesiosis when compared to apparently healthy animals 29 , 33 . Differences were obtained also between the dogs infected with different Babesia parasites, with significantly lower A/G ratio in the animals infected with B. gibsoni than in B. canis infected dogs.…”

Section: Discussionmentioning

confidence: 82%

Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis

Tóthová

Karasová

Blaňárová

et al. 2020

Sci Rep

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Canine babesiosis may cause several hematological and biochemical changes, but only limited studies are available regarding the possible differences of changes in animals infected by different Babesia parasites. The study focused on the evaluation of the differences in serum protein electrophoretic pattern between dogs naturally infected with B. gibsoni (17 dogs) and B. canis (40 dogs). The mean values of total proteins, β1-, β2- and γ-globulins were in dogs infected with B. gibsoni significantly higher (P < 0.05 and P < 0.001) than in dogs infected with B. canis. The relative concentrations of albumin, α1-, α2-globulins and the A/G ratios were in the B. gibsoni infected dogs significantly lower (P < 0.001), no significant differences were found in the relative concentrations of β1- and β2-globulins. Significant differences were found in most of the evaluated parameters when comparing the results in relation to the form of B. canis infection to B. gibsoni infection. Hematological indices showed significant differences between dogs infected with B. gibsoni and the complicated form of B. canis infection. In conclusion, the obtained results suggest differences in the changes of serum protein electrophoretic pattern between dogs infected with both Babesia species and thus, in the response to the infection caused by various Babesia parasites.

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Clinical Efficacy and Safety of Malarone®, Azithromycin and Artesunate Combination for Treatment of Babesia gibsoni in Naturally Infected Dogs

Karasová

Tóthová

Víchová

et al. 2022

Animals

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Babesia gibsoni is a tick-borne protozoal blood parasite that may cause hemolytic anemia, thrombocytopenia, lethargy, and/or splenomegaly in dogs. Many drugs have been used in management of canine babesiosis such as monotherapy or combined treatment, including diminazene aceturate, imidocarb dipropionate, atovaquone, and antibiotics. This report examines the effectiveness and safety of Malarone®, azithromycin (AZM) and artesunate (ART) combination for the treatment of babesiosis in dogs naturally infected with Babesia gibsoni. Twelve American Pit Bull Terriers were included in the experiment. Examined dogs underwent clinical and laboratory analysis including hematology and biochemistry profile and serum protein electrophoresis. After diagnosis, the dogs received combined therapy with Malarone® (13.5 mg/kg PO q24 h), azithromycin (10 mg/kg PO q24 h) and artesunate (12.5 mg/kg PO q24 h) for 10 days. The combined treatment improved hematology and biochemical parameters to the reference range gradually during the first 14 days already, resulting in the stable values until day 56 after treatment. No clinically apparent adverse effects were reported during treatment and monitoring. No relapses of parasitemia were detected in control days 180, 360, 540 and 720 in all dogs. Results of the study indicate that the combined treatment leads to successful elimination of parasitemia in chronically infected dogs with B. gibsoni.

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Jaundice In Dog Associated With Babesiosis

Cited by 4 publications

References 0 publications

Clinicopathological alterations in naturally occurring Babesia gibsoni infection in dogs of Middle-South Gujarat, India

Clinicopathological alterations in naturally occurring Babesia gibsoni infection in dogs of Middle-South Gujarat, India

Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis

Clinical Efficacy and Safety of Malarone®, Azithromycin and Artesunate Combination for Treatment of Babesia gibsoni in Naturally Infected Dogs

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