JC Virus T-Antigen DNA in Gastrointestinal Mucosa of Immunosuppressed Patients: A Prospective, Controlled Study

Boltin, Doron; Vilkin, Alex; Levi, Zohar; Elkayam, Ori; Niv, Yaron

doi:10.1007/s10620-009-0986-y

Cited by 8 publications

(9 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, JCV is a good candidate to be the missing link in familial CRC when obvious genetic explanation is missing. In previous studies, we demonstrated a correlation between positive serology to JCV and CRC or adenomatous polyps, as well as JCV DNA in the tumors in CRC Israeli patients and in the normal colonic mucosa of immunosuppressed patients [14][15][16]. In the present study, we found JCV T Ag in the tumor tissue or in adjacent normal mucosa in almost twice as many of the patients with a family history of CRC than in patients with no such family history.…”

Section: Discussionsupporting

confidence: 75%

Presence of JC Virus DNA in the Tumor Tissue and Normal Mucosa of Patients with Sporadic Colorectal Cancer (CRC) or with Positive Family History and Bethesda Criteria

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 75%

Presence of JC Virus DNA in the Tumor Tissue and Normal Mucosa of Patients with Sporadic Colorectal Cancer (CRC) or with Positive Family History and Bethesda Criteria

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…JCV has been detected in stools or intestinal mucosa of healthy individuals and immunocompromised patients, including transplant recipients . The virus has also been isolated from glial cells of the myenteric plexus and has been implicated in development of chronic idiopathic intestinal pseudo‐obstruction .…”

Section: Discussionmentioning

confidence: 99%

“…As with BKV, JCV remains latent in the kidney and bone marrow after primary infection . The latent virus has also been detected in the upper and lower gastrointestinal mucosa of immunosuppressed patients . Reactivation of the virus can cause PML, a severe and often lethal demyelinating disease of the central nervous system .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Progressive multifocal leukoencephalopathy with gastrointestinal disease in a pediatric kidney transplant recipient

Burke

Trnka

Walsh

et al. 2013

Pediatric Transplantation

View full text Add to dashboard Cite

PML is a demyelinating disease of the central nervous system caused by infection with JCV. Several cases of PML in bone marrow and solid organ transplant recipients have been reported in recent years. JCV has been isolated from the gastrointestinal mucosa of immunocompromised patients, but there are no published reports of PML associated with symptomatic gastrointestinal involvement in kidney transplant recipients. We report a case of a nine-yr-old girl with a kidney transplant who developed a severe gastrointestinal illness causing pseudo-obstruction in association with PML. JCV was suspected as the causative agent in this patient by the detection of high JCV titer through PCR analysis of the cerebrospinal fluid and blood and positive staining for simian virus 40 in the colon. JCV intestinal infection should be considered in kidney transplant recipients presenting with intestinal pseudo-obstruction.

show abstract

“…Few studies have addressed the prevalence of JCPyV in tumors of immunosuppressed patients. In a recent study, Bolting et al observed a higher prevalence of JCPyV DNA in the normal mucosa of the gastrointestinal tracts of patients who received immunosuppressant therapy than in immunocompetent control individuals (23,7% vs. 6,3%; p = 0,02) 172 . Importantly, organ transplant recipients exhibited a relative risk of 10.4 (prevalence 35,3%) for carrying viral DNA.…”

Section: Introductionmentioning

confidence: 92%

Human polyomaviruses and cancer: an overview

Prado¹,

Monezi²,

Amorim³

et al. 2018

Clinics

View full text Add to dashboard Cite

The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the capacity of mediating cell transformation and tumorigenesis in different experimental models. The transformation process mediated by these viruses is driven by viral pleiotropic regulatory proteins called T (tumor) antigens. Similar to other viral oncoproteins T antigens target cellular regulatory factors to favor cell proliferation, immune evasion and downregulation of apoptosis. The first two human polyomaviruses were isolated over 45 years ago. However, recent advances in the DNA sequencing technologies led to the rapid identification of additional twelve new polyomaviruses in different human samples. Many of these viruses establish chronic infections and have been associated with conditions in immunosuppressed individuals, particularly in organ transplant recipients. This has been associated to viral reactivation due to the immunosuppressant therapy applied to these patients. Four polyomaviruses namely, Merkel cell polyomavirus (MCPyV), Trichodysplasia spinulosa polyomavirus (TSPyV), John Cunningham Polyomavirus (JCPyV) and BK polyomavirus (BKPyV) have been associated with the development of specific malignant tumors. However, present evidence only supports the role of MCPyV as a carcinogen to humans. In the present review we present a summarized discussion on the current knowledge concerning the role of MCPyV, TSPyV, JCPyV and BKPyV in human cancers.

show abstract

JC Virus T-Antigen DNA in Gastrointestinal Mucosa of Immunosuppressed Patients: A Prospective, Controlled Study

Abstract: JCV T-Ag DNA is more prevalent in the upper and lower GI mucosa of immunosuppressed patients, possibly indicating that the virus resides in these patients. This may account for the higher prevalence of GI carcinomas in immunosuppressed patients.

Cited by 8 publications

References 40 publications

Presence of JC Virus DNA in the Tumor Tissue and Normal Mucosa of Patients with Sporadic Colorectal Cancer (CRC) or with Positive Family History and Bethesda Criteria

Presence of JC Virus DNA in the Tumor Tissue and Normal Mucosa of Patients with Sporadic Colorectal Cancer (CRC) or with Positive Family History and Bethesda Criteria

Progressive multifocal leukoencephalopathy with gastrointestinal disease in a pediatric kidney transplant recipient

Human polyomaviruses and cancer: an overview

Contact Info

Product

Resources

About