Jejunal Casein Feeding Is Followed by More Rapid Protein Digestion and Amino Acid Absorption When Compared with Gastric Feeding in Healthy Young Men,

Luttikhold, Joanna; Norren, Klaske van; Buijs, Nikki; Ankersmit, Marjolein; Heijboer, Annemieke C.; Gootjes, Jeannette; Rijna, Herman; Leeuwen, Paul A. M. van; Loon, Luc J. C. van

doi:10.3945/jn.115.211615

Cited by 8 publications

(1 citation statement)

References 33 publications

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“…this has been studied using liquid feeds, which may underestimate the stomach's role in the mechanical breakdown and chemical digestion or protein molecules within complex food matrixes (Luttikhold et al, 2015). In contrast, recent in vitro models have shown decreased meat and soy protein hydrolysis when lower gastric acidity is simulated (Wang et al, 2022).…”

Section: Protein Digestion and Absorptionmentioning

confidence: 99%

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

Stillhart

Asteriadis

Bocharova

et al. 2023

European Journal of Pharmaceutical Sciences

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Section: Protein Digestion and Absorptionmentioning

confidence: 99%

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

Stillhart

Asteriadis

Bocharova

et al. 2023

European Journal of Pharmaceutical Sciences

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Measuring the oral bioavailability of protein hydrolysates derived from food sources: A critical review of current bioassays

Abeer

Trajkovic

Brayden

2021

Biomedicine & Pharmacotherapy

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Let thy food be thy medicine….when possible

Witkamp

Norren

2018

European Journal of Pharmacology

101

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There is no evidence that Hippocrates, although being credited for it, ever literally stated 'let thy food be thy medicine and thy medicine be thy food'. However, yet in line with Hippocrates' philosophy, we are currently witnessing a reappraisal of the complementarity of nutrition and pharmacology. Recent studies not only underline the therapeutic potential of lifestyle interventions, but are also generating valuable insights in the complex and dynamic transition from health to disease. Next to this, nutritional biology can significantly contribute to the discovery of new molecular targets. It is clear that most of the current top-selling drugs used in chronic cardio-metabolic diseases modulate relatively late-stage complications, which generally indicate already longer existing homeostatic imbalances. Pharmacologists are increasingly aware that typical multifactorial disorders require subtle, multiple target pharmacological approaches, instead of the still often dominating 'one disease - one target - one drug' paradigm. This review discusses the recent developments in the pharma-nutrition interface and shows some relevant mechanisms, including receptors and other targets, and examples from clinical practice. The latter includes inflammatory diseases and progressive loss of muscle function. The examples also illustrate the potential of targeted combinations of medicines with nutrition and (or) other life-style interventions, to increase treatment efficacy and (or) reduce adverse effects. More attention to a potentially negative outcome of drug-food combinations is also required, as shown by the example of food-drug interactions. Together, the developments at the food-pharma interface underline the demand for intensified collaboration between the disciplines, in the clinic and in science.

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Jejunal Casein Feeding Is Followed by More Rapid Protein Digestion and Amino Acid Absorption When Compared with Gastric Feeding in Healthy Young Men,

Cited by 8 publications

References 33 publications

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

Measuring the oral bioavailability of protein hydrolysates derived from food sources: A critical review of current bioassays

Let thy food be thy medicine….when possible

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