Jejunal Morphology in Multiple Sclerosis

Bateson, M C; Hopwood, David A.; Macgillivray, J. B.

doi:10.1016/s0140-6736(79)91790-2

Cited by 17 publications

(6 citation statements)

References 10 publications

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“…Cu (jmol/1) 15-1 ± 3-2* 16-9 ± 2-1 16-7 ± 34 16-6 ± 2.3 Albumin (g/l) Slowly progressive Mean age 42 + 14 (n = 12) 42 + 13 39 ± 10 (n = 8) 39 + 9 Zn 12-2 + 1-6t 14-6 + 1-9 11-0 + 1-2 12-4 + 1-9 Cu 15-5 ± 3-6 15.3 ± 1-9 15-6 + 3-5 17-1 + 2-6 Albumin 43 ± 3 42 ± 4 39 ± 5 40 ± 3 * = p<005, t = p < 0-01, = p < 0.001 4-2 ± 1-2 *p < 0-05 serum Cu concentrations. The males with moderate or severe disability and a duration of more than six years had lower serum Zn concentrations than the controls.…”

Section: Controls Ms Controlsmentioning

confidence: 99%

Zinc and copper in multiple sclerosis.

Palm¹,

Hallmans²

1982

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY The serum concentrations of zinc and copper were measured in 50 patients with multiple sclerosis. Lower serum zinc levels were found compared to age-and sex-matched controls. In younger patients low serum copper concentrations were noted. Zinc concentrations in CSF were unchanged. The possibility that malabsorption of the metals causes the low serum concentrations is discussed.In the search for the aetiology and pathogenesis of multiple sclerosis some interest has been expressed in the role of the trace elements zinc (Zn) and copper (Cu). Epidemiological data has shown a low prevalence of the disease in seacoast towns,' where the intake of seafood, rich in Zn, is high.2 Zinc and copper deficiency in some animal species may lead to hypomyelinisation.39 Conflicting reports of serum and plasma concentrations of Zn and Cu in multiple sclerosis have been published. Plasma Zn has been reported to be increased in 50 patients.'0 Decreased plasma Zn levels were reported by Wong et all" in 25 patients, 14 of whom had clinically definite multiple sclerosis. Serum Cu has been reported to be decreased,'2 or unchanged."'-6 In addition, serum albumin, which binds about 80% of the Zn in serum,'7 has been said to be decreased'8-20 or unchanged,'0 while the serum a2-macroglobulin, which binds about 20% of the Zn in serum, has been said to be depressed.'0 18-20 Transient elevations of several acute-phase reactants in serum, for example C3-pro-activator, C-reactive protein, orosomucoid and IgM, have been found during exacerbations of the disease.2'The aim of the present study was to correlate changes in the serum concentrations of Zn, Cu and albumin in multiple sclerosis patients with the age of the patients, the phase and duration of the disease, and the degree of disability. In addition the concentrations of CSF Zn were determined, and their relationship to the CSF proteins studied.

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Section: Controls Ms Controlsmentioning

confidence: 99%

Zinc and copper in multiple sclerosis.

Palm¹,

Hallmans²

1982

Journal of Neurology, Neurosurgery & Psychiatry

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“…Several studies showed the lack of significant association between MS and gluten sensitive enteropathy[91011] and jejunal biopsy specimen results in MS patients have been found to be normal. [11] Previous researchers have investigated the role of a GFD in the treatment of MS and found no benefits.…”

Section: Discussionmentioning

confidence: 99%

“…[11] Previous researchers have investigated the role of a GFD in the treatment of MS and found no benefits. [12] The relapsing-remitting natural history of MS can make interpretations very difficult.…”

Section: Discussionmentioning

confidence: 99%

Multiple sclerosis or neurological manifestations of Celiac disease

2013

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“…[12][13][14] Ho we ver the re is litt le in for ma ti on abo ut the fre quency of CD in MS and it has be en re por ted that the je ju nal bi op si es are nor mal in pa ti ents with MS. 4 In 2008, Fer ro et al 5 re por ted a ca se of MS ha ving hea dac he comp la ints first, and la ter di ag no sed as "silent CD". Pen gi ran Ten gah et al 3 pub lis hed two ca ses ha ving whi te mat ter le si ons li ke MS in bra in MRI without any ce reb ros pi nal flu id oli goc lo nal band po si ti vity and the patients were la ter di ag no sed "si lent CD".…”

Section: Discussionmentioning

confidence: 99%

“…To further investigate this observation, small intestine biopsy studies were carried out in patients with MS; yet no symptoms that could be associated with CD were found. 4 Nevertheless, in patients who were diagnosed with CD years after the diagnosis of MS, it was still considered that the association of MS and CD could represent not a coincidence but a common autoimmune or genetic Association of Multiple Sclerosis and Celiac Disease: Case Report A AB BS S T TR RA AC CT T The as so ci a ti on of mul tip le scle ro sis and ce li ac di se a se is re cently des cri bed in ca se re ports alt ho ugh cli ni cal sig ni fi can ce of this as so ci a ti on is not cle ar, and it is dif fi cult to de ci de whet her ob ser ved ne u ro lo gic ab nor ma li ti es ori gi na te du e to ce li ac di se a se it self or sus pec ted accom pan ying mul tip le scle ro sis. The as so ci a ti on of mul tip le scle ro sis and ce li ac di se a se, if pre sent may be du e to a com mon ge ne tic or au to im mu ne ba sis.…”

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confidence: 99%