Multiple sclerosis or neurological manifestations of Celiac disease

Abstract

Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune disease. We discuss about a known case of CD-showed relapsing – remitting neurological symptoms compatible with MS. In this rare co-occurrence subject, MS-CD patient, the interaction between MS – and CD-related inflammatory processes is open to discussion.

Celiac Disease and Its Association with Organ-Specific Auto-Immune Diseases

“…Tests done for the brain MRI indicated a demyelinating condition of plaques without any structural abnormality in the cerebellum. Various other neurological factors led to the clinical diagnosis of MS (Shaygannejad et al, 2013).…”

Multiple sclerosis and susceptibility to celiac disease: An osteopontin gene haplotypes affair?

“…Abundant amounts of OPN have been found in plaques dissected from brains of patients with MS, whereas it is absent in control brain tissue [6]. Case reports have observed the combined presence of MS and celiac disease (CD) [7][8][9]. However, the relationship between MS and CD is controversial and debated [7][8][9].…”

“…Case reports have observed the combined presence of MS and celiac disease (CD) [7][8][9]. However, the relationship between MS and CD is controversial and debated [7][8][9]. CD is a lifelong systemic autoimmune disorder triggered by dietary gluten in genetically predisposed individuals [10].…”

“…CD can occur at any age, from infancy to late in life [10]. The pathogenesis of CD is related to interactions among genetic, environmental and immunological factors [7][8][9][10]. Abnormal Th1 and Th17 cell responses are thought to play a central role in both the induction and persistence of chronic inflammation in the gut by producing proinflammatory cytokines [7][8][9][10][11].…”