Jejunal mucosal abnormalities in patients with recurrent aphthous ulceration.

Ferguson, Roger K.; Basu, M. K.; Asquith, P.; Cooke, W. T.

doi:10.1136/bmj.1.6000.11

Cited by 80 publications

(41 citation statements)

References 11 publications

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“…An association between oral ulcers, diarrhea, and weight loss has been described for more than 3 centuries, 46 and the early studies that investigated the prevalence of CD in patients affected by RAS reported very high values (Table 4). Notably, Ferguson et al 46 quoted a 24.24% prevalence of CD in 33 patients with RAS, and asserted the importance of performing jejunal biopsy in subjects with recurrent aphthae.…”

Section: And Oral Soft Tissue Lesions Rasmentioning

confidence: 99%

“…In fact, several authors reported significant improvement, if not complete remission, of oral aphthae in most CD patients which had been placed on GFD, 16,46,55,65 and reappearance of recurrences with the reintroduction of gluten. 52,54,62,63 Furthermore, patients with RAS and no histologic evidence of CD showed a favorable response to GFD and a positive gluten challenge, suggesting the existence of a form of gluten-sensitive RAS.…”

Section: And Oral Soft Tissue Lesions Rasmentioning

confidence: 99%

“…Notably, Ferguson et al 46 quoted a 24.24% prevalence of CD in 33 patients with RAS, and asserted the importance of performing jejunal biopsy in subjects with recurrent aphthae. Subsequent studies [54][55][56] lessened this matter, albeit they reported CD prevalence values higher than those expected for the normal population, and thus supported the hypothesis of a correlation between CD and RAS.…”

Section: And Oral Soft Tissue Lesions Rasmentioning

confidence: 99%

See 2 more Smart Citations

Oral Manifestations of Celiac Disease

Pastore

Carroccio²,

Compilato

et al. 2008

Journal of Clinical Gastroenterology

105

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Section: And Oral Soft Tissue Lesions Rasmentioning

confidence: 99%

Section: And Oral Soft Tissue Lesions Rasmentioning

confidence: 99%

Section: And Oral Soft Tissue Lesions Rasmentioning

confidence: 99%

See 1 more Smart Citation

Oral Manifestations of Celiac Disease

Pastore

Carroccio²,

Compilato

et al. 2008

Journal of Clinical Gastroenterology

105

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“…36 Dental enamel defects and aphthous stomatitis can suggest subclinical CD. 37,38 Sometimes, CD patients have a gluten-sensitive dysmotility involving the whole gastrointestinal tract, and the clinical expression may be dyspepsia, reflux, dysphagia or, more frequently, severe constipation. 39 Irritable bowel syndrome, common in the general population, can hide a condition of gluten-sensitive enteropathy.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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Until a few years ago, celiac disease (CD) was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa. Currently, CD is regarded as an autoimmune disorder that is common in the general population (affecting 1 in 100 individuals), with possible onset at any age and with many possible presentations. The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal (constipation and recurrent abdominal pain) and extra-intestinal symptoms (anemia, raised transaminases, osteoporosis, recurrent miscarriages, aphthous stomatitis and associated autoimmune disorders), or it could be completely symptomless. Over the last 20 years, the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests, such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies. The routine use of antibody markers has allowed researchers to discover a very high number of 'borderline' cases, characterized by positive serology and mild intestinal lesions or normal small intestine architecture, which can be classified as potential CD. Therefore, it is evident that the 'old celiac disease' with flat mucosa is only a part of the spectrum of CD. It is possible that serology could identify CD in its early stages, before the appearance of severe intestinal damage. In cases with a positive serology but with mild or absent intestinal lesions, the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

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“…1 Some authors state that patients with RAS have a higher prevalence of celiac disease and that RAS may be their first complaint. [10][11][12][13] The role of genetic factors is also important in the etiology of RAS, as it is thought that at least 40% of patients with RAS have a family history of that condition. These patients tend to develop RAS at an earlier age, with more-severe symptoms and frequent episodes.…”

Section: Introductionmentioning

confidence: 99%

Characterization of recurrent aphthous stomatitis in a young population

Oliveira¹,

Coimbra²,

Mesquita³

et al. 2018

j.rpemd

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Aim: To characterize recurrent aphthous stomatitis in a young population and investigate the association between these lesions and predisposing factors, as well as potential modifications in children's daily routines. Methods:The data was collected by delivering a questionnaire to students attending S. Miguel Primary School, in Vizela, as well as to their parents/guardians. A literature review was conducted, using scientific databases such as PubMed, Cochrane and the Virtual Library of the University of Porto.Results: A common prevalence of aphthous ulcers was found in 53.0% of the sample. Most participants reported a number of lesions between 1 and 5, located in the jugal/labial mucosa, healing within 4 to 7 days. About 46.4% of the participants had a family history of this disease, mainly on the mother's side. About 29.6% of the students associated aphthae with traumatic events in the oral mucosa, while 9.8% associated them with stress. A significant association was found only between the frequency of aphthae and gastrointestinal disorders, and not with other factors. A significant use of topical medications was detected, and the pharmacist was the most consulted healthcare professional. Conclusion

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Jejunal mucosal abnormalities in patients with recurrent aphthous ulceration.

Cited by 80 publications

References 11 publications

Oral Manifestations of Celiac Disease

Oral Manifestations of Celiac Disease

Celiac disease: diagnostic criteria in progress

Characterization of recurrent aphthous stomatitis in a young population

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