Pre-chamber turbulent jet ignition represents one of the most promising techniques to improve spark ignition engines efficiency and reduce pollutant emissions. This technique consists of igniting the air-fuel mixture in the main combustion chamber by means of several hot turbulent flame jets exiting a pre-chamber. In the present study, the combustion process of a 4-stroke, gasoline SI, PFI engine equipped with a passive pre-chamber has been investigated through three-dimensional CFD (Computational Fluid Dynamics) analysis. A detailed chemistry solver with a reduced reaction mechanism was employed to investigate ignition and flame propagation phenomena. Firstly, the combustion model was validated against experimental data for the baseline engine configuration (i.e., without pre-chamber). Eventually, the validated numerical model allowed for predictive simulations of the pre-chamber-equipped engine. By varying the shape of the pre-chamber body and the size of pre-chamber orifices, different pre-chamber configurations were studied. The influence of the geometrical features on the duration of the combustion process and the pressure trends inside both the pre-chamber and main chamber was assessed and discussed. Since the use of a pre-chamber can extend the air-fuel mixture ignition limits, an additional sensitivity on the air-fuel ratio was carried out, in order to investigate engine performance at lean conditions.