Jet lag: Therapeutic use of melatonin and possible application of melatonin analogs

Srinivasan, V.; Spence, D. Warren; Pandi-Perumal, Seithikurippu R.; Trakht, Ilya; Cardinali, Daniel P.

doi:10.1016/j.tmaid.2007.12.002

Cited by 75 publications

(52 citation statements)

References 107 publications

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“…Melatonin has the capacity to alter the timing of circadian rhythms, and functions in concert with light to synchronize circadian rhythms with the prevailing light/dark cycles. Melatonin has been used therapeutically in treating various circadian rhythm sleep disorders such as the delayed sleep phase syndrome, shift work sleep disorder, jet lag or blindness [21][22][23][24] .…”

Section: Basic Physiology Of Melatoninmentioning

confidence: 99%

Melatonin and the Immune System in Aging

Cardinali¹,

Esquifino²,

Srinivasan³

et al. 2008

Neuroimmunomodulation

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132

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Aging is associated with a decline in immune function (immunosenescence), a condition known to correlate with increased incidence of cancer as well as infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. Circulating melatonin decreases with age, and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes and macrophages. It also stimulates the production of natural killer cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from natural killer cells and T helper lymphocytes are enhanced by melatonin. Melatonin has the potential therapeutic value to enhance immune function in aged individuals.

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Section: Basic Physiology Of Melatoninmentioning

confidence: 99%

Melatonin and the Immune System in Aging

Cardinali¹,

Esquifino²,

Srinivasan³

et al. 2008

Neuroimmunomodulation

Self Cite

132

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“…It is characterized by decreased alertness, nighttime insomnia, poor overall performance (3), impaired cognitive skills (4), loss of appetite, depressed mood, reduced psychomotor coordination, and gastrointestinal disturbances (5). The severity and extent of these symptoms depend on the direction and speed of travel and the number of time zones crossed (5)(6)(7)(8). Individuals exposed to chronic jet lag may experience accelerated malignant growth (9) and temporal lobe atrophy combined with spatial cognitive deficits (10).…”

Section: Introductionmentioning

confidence: 99%

Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag

2010

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Jet lag encompasses a range of psycho-and physiopathological symptoms that arise from temporal misalignment of the endogenous circadian clock with external time. Repeated jet lag exposure, encountered by business travelers and airline personnel as well as shift workers, has been correlated with immune deficiency, mood disorders, elevated cancer risk, and anatomical anomalies of the forebrain. Here, we have characterized the molecular response of the mouse circadian system in an established experimental paradigm for jet lag whereby mice entrained to a 12-hour light/12-hour dark cycle undergo light phase advancement by 6 hours. Unexpectedly, strong heterogeneity of entrainment kinetics was found not only between different organs, but also within the molecular clockwork of each tissue. Manipulation of the adrenal circadian clock, in particular phase-shifting of adrenal glucocorticoid rhythms, regulated the speed of behavioral reentrainment. Blocking adrenal corticosterone either prolonged or shortened jet lag, depending on the time of administration. This key role of adrenal glucocorticoid phasing for resetting of the circadian system provides what we believe to be a novel mechanism-based approach for possible therapies for jet lag and jet lag-associated diseases.

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“…In all patients, an AHI of less than 5/h was achieved. The CPAP treatment also resulted in a reduction in daytime sleepiness (median [IQR] ESS score, 13 [8][9][10][11][12][13][14][15][16][17][18][19][20] Baseline serum melatonin concentrations In the majority of the study population, the highest serum melatonin levels were noted at 2 AM (FIGURE 2). This finding was reported for all controls and for 53 of the 71 patients (74.6%) with OSA.…”

Section: Methodsmentioning

confidence: 99%

“…28 During the first 2 nights of hospital treatment, all 71 patients with indications lag symptoms and sleep disorders related with night-shift work. 13,14 Obstructive sleep apnea (OSA) is a common condition characterized by recurrent airflow limitation in the upper airways, leading to a decrease in blood oxygenation and subsequent arousals. The prevalence of OSA depends on age and sex, among other factors, and is estimated at 13% in men and 6% in women aged 30 to 70 years; it has shown a relative percentage increase by 14% to 55% over the last 20 years.…”

mentioning

confidence: 99%

Treatment with continuous positive airway pressure and diurnal and nocturnal serum melatonin concentration in patients with obstructive sleep apnea

Barnaś¹,

Maskey-Warzęchowska²,

Bielicki³

et al. 2017

Polish Archives of Internal Medicine

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ORIGINAL ARTICLE CPAP treatment and serum melatonin in OSA 589 models and humans have shown that melatonin secretion is strongly related to sleep, and individuals with decreased melatonin levels suffer from sleep disturbances and insomnia. This refers to elderly patients (as melatonin concentrations tend to fall with age), night-shift workers with an exogenously disrupted sleep-wake rhythm, individuals who had undergone pinealectomy, and others.1,2,10 In patients with primary insomnia, exogenous melatonin decreases sleep onset latency, increases total sleep time, and improves sleep quality. 11,12 Melatonin also effectively reduces jet INTRODUCTION Melatonin is a serotonin-derived hormone secreted by the pineal gland in a cyclic manner. 1 It has diverse activities and regulates numerous physiological processes in mammals, including the sleep-wake rhythm, sexual maturation, reproduction, and aging. It also has antioxidant, oncostatic, and immunomodulative properties.1-3 Its release responds to the light-dark cycle.4-6 The peak melatonin secretion occurs during the night hours; during the day, its concentrations are low. Exposure to light acutely suppresses nocturnal melatonin release. OBJECTIVES The aim of the study was to evaluate the profile of circadian melatonin secretion in patients with obstructive sleep apnea (OSA) and to assess the impact of 2-day and 3-month treatment with continuous airway pressure (CPAP) on diurnal and nocturnal serum melatonin levels.PATIENTS AND METHODS Serum melatonin levels were evaluated in 71 untreated patients with OSA and 18 healthy controls at 6 time points: 10 AM, 2 PM, 6 PM, 10 PM, 2 AM, and 6 AM. The measurements were repeated after 2 days and 3 months of CPAP treatment. RESULTSMelatonin secretion rhythm was altered in 25.4% of the patients with OSA. In patients with preserved secretion rhythm, the serum melatonin level was significantly lower at 2 AM and 6 AM, compared with healthy controls: 68.2 pg/ml (interquartile range [IQR], 30.1-109.8 pg/ml) vs 109.1 pg/ml (IQR, 63-167.9 pg/ml), P = 0.02 and 40.8 pg/ml (IQR,.2 pg/ml) vs 67.7 pg/ml (IQR, 32.7-131.7 pg/ml), P = 0.04, respectively. Melatonin levels did not change significantly after the 2-day and 3-month CPAP treatment. However, at 3 months, a shift of the peak melatonin concentration to 2 AM was observed in patients with an altered secretion rhythm.CONCLUSIONS OSA has a significant effect on serum melatonin levels. Neither short-term nor long-term CPAP treatment significantly changes melatonin concentrations; however, our results seem to indicate that a 3-month CPAP treatment may be helpful in restoring the physiological rhythm of melatonin secretion in patients with OSA.

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Jet lag: Therapeutic use of melatonin and possible application of melatonin analogs

Cited by 75 publications

References 107 publications

Melatonin and the Immune System in Aging

Melatonin and the Immune System in Aging

Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag

Treatment with continuous positive airway pressure and diurnal and nocturnal serum melatonin concentration in patients with obstructive sleep apnea

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