Jiaotai Pill (交泰丸) Alleviates Insomnia through Regulating Monoamine and Organic Cation Transporters in Rats

Li, Zhihui; Ma, Pengkai; Huang, Yun-Fang; Zhang, Zhe; Zheng, Wei; Chen, Jianhua; Guo, Chang-E; Chen, Ning; Bi, Xin-Ning; Zhang, Yujie

doi:10.1007/s11655-021-3284-y

Cited by 9 publications

(4 citation statements)

References 28 publications

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“…The open field test is one of the most common behavioral indicators in neurological research. 39,58,59 For the description of the open field test indicators, Bale et al pointed out that mice with anxious behavior showed less traverse time in the central area. 60 Correspondingly, Kraeuter et al indicated that mice with lower anxiety prefers to be active in the central area of the open field.…”

Section: Gsw Alleviates Anxiety-like Behaviorsmentioning

confidence: 99%

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Amelioration effect of water extract from Ganoderma resinaceum FQ23 solid-state fermentation fungal substance with high-yield ergothioneine on anxiety-like insomnia mice

Huang

Zhang

et al. 2022

Food Funct.

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Section: Gsw Alleviates Anxiety-like Behaviorsmentioning

confidence: 99%

“…9(a)), which is consistent with the regulation trend of the 5-HT and GABA levels in the vast majority of food and medicine resources to improve sleep. 38,59 Therefore, GSW has an ameliorative effect on sleep regulation-related 5-HT and GABA levels.…”

Section: Gsw Improves the Antioxidant Function Of Organsmentioning

confidence: 99%

Amelioration effect of water extract from Ganoderma resinaceum FQ23 solid-state fermentation fungal substance with high-yield ergothioneine on anxiety-like insomnia mice

Huang

Zhang

et al. 2022

Food Funct.

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“…(3) Chaihu-Longgumuli decoction inhibits adrenocorticotropic hormone and corticosterone, both of which may be involved in regulating insomnia [76]. (4) Jiaotai Pill alleviated insomnia by regulating the monoaminergic system and activities of organic cation transporters in the hypothalamus and peripheral organs [77]. (5) Jiaotai Pill might promote the repair of intestinal epithelial barriers and suppress the systemic inflammation and cognitive impairment in sleep-deprived rats [78].…”

Section: The Underlying Mechanism Of Hmmentioning

confidence: 99%

Traditional East Asian Herbal Medicine for Post-Stroke Insomnia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kim

Lim

2022

IJERPH

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Post-stroke insomnia (PSI) is a highly prevalent complication after stroke. Current evidence of psychotropic drug use for PSI management is scarce and indicates harmful adverse events (AEs). Traditional East Asian herbal medicine is a widely used traditional remedy for insomnia. However, so far, no study has systematically reviewed the efficacy and safety of traditional east asian herbal medicine (HM) for PSI. Therefore, we perform meta-analysis to evaluate the effectiveness and safety of HM for PSI. After a comprehensive electronic search of 15 databases, we review the randomized controlled trials (RCTs) of HM use as monotherapy for PSI. Our outcomes were the Pittsburgh sleep quality index and total effective rate. In total, 24 RCTs were conducted with 1942 participants. HM showed statistically significant benefits in sleep quality. It also appeared to be safer than psychotropic drugs in terms of AEs, except when the treatment period was two weeks. The methods used for RCTs were poor, and the quality of evidence assessed was graded “low” or “moderate.” The findings of this review indicate that the use of HM as a monotherapy may have potential benefits in PSI treatment when administered as an alternative to conventional medications. However, considering the methodological quality of the included RCTs, we were uncertain of the clinical evidence. Further, well-designed RCTs are required to confirm these findings.

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“…The existing experimental study of JTP shows that JTP could modulate the permeability of the gut barrier and microbiota in animal model of insomnia [ 7 ]. In brain tissue, JTP increases γ -aminobutyric acid levels and modulates the hypothalamic monoaminergic system and organic cation transporters [ 9 ]. In the intestine, JTP protects gut mucosa, regulates rhythm proteins [ 10 ], and decreases levels of lipopolysaccharides and inflammatory factors [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics

Yang

Liu

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. With the continuous advancement of clinical application and experimental research of JTP, the application prospect of JTP in nervous system diseases and metabolic diseases is becoming increasingly clear. Jiaotai Pill (JTP) is a traditional Chinese medicine formula for insomnia, consisting of Coptidis rhizoma and Cinnamomi cortex, which dates back to Han Shi Yi Tong in the Ming Dynasty of China. Objective. Based on the brain-gut axis theory, this paper aims to explore the potential mechanism of JTP in the intervention of insomnia by using intestinal microbiome and metabolomics technology, taking the animal model of insomnia as the research object, so as to provide experimental basis for its further application and research. Methods. The insomnia mouse model was induced by intraperitoneal injection of para-chlorophenylalanine (PCPA). The clinical equivalent dose of JTP was administered by gavage for one week. The efficacy of JTP was evaluated by behavioral tests, serum biochemical detection, and brain histomorphological observation. The contents of cecum were analyzed by microbiomics and metabolomics. Results. The results show that insomnia caused by PCPA led to daytime dysfunction, higher HPA axis hormone levels, and morphologically impaired hippocampus. JTP reversed these anomalies. Omics research indicates that JTP significantly reduced gut α diversity; at the phylum level, JTP reduced the relative abundance of Firmicutes, Deferribacterota, Cyanobacteria, and Actinobacteriota and increased the relative abundance of Verrucomicrobiota, Proteobacteria, and Desulfobacterota. At the genus level, JTP reduced the relative abundance of Muribaculaceae, Lachnospiraceae_NK4A136_group, Alistipes, Colidextribacter, Muribaculum, and Mucispirillum and increased the relative abundance of Bacteroides and Akkermansia. JTP also reversed the activation of the linoleic acid metabolism pathway induced by insomnia. The combined analysis of omics suggests that JTP may play a role by regulating the inflammatory state of the body. Further gene expression analysis of brain tissue confirmed this. Conclusions. We hypothesize that JTP may achieve insomnia relief by eliminating inflammation-causing bacteria in the gut and reducing inflammation levels through the brain-gut axis, pointing to potential targets and pathways for future research on JTP.

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Jiaotai Pill (交泰丸) Alleviates Insomnia through Regulating Monoamine and Organic Cation Transporters in Rats

Cited by 9 publications

References 28 publications

Amelioration effect of water extract from Ganoderma resinaceum FQ23 solid-state fermentation fungal substance with high-yield ergothioneine on anxiety-like insomnia mice

Amelioration effect of water extract from Ganoderma resinaceum FQ23 solid-state fermentation fungal substance with high-yield ergothioneine on anxiety-like insomnia mice

Traditional East Asian Herbal Medicine for Post-Stroke Insomnia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics

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