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Milki, Amin A.; Jun, Suckjoon; Hinckley, Mary D; Westphal, Lynn W.; Giudice, Linda C.; Behr, Barry

doi:10.1023/a:1024861624805

Cited by 47 publications

(9 citation statements)

References 20 publications

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“…Although this was not a definite conclusion, related studies showed a trend that ICSI would decreased the SSR comparing to in vitro fertilization (IVF) [ 4 , 5 ]. Some researchers specifically used systematic review to clarify that blastocyst stage transplantation might increase the SSR when it was compared with cleavage stage transplantation [ 4 – 6 ]. Other aspects, single or multiple births might also have an influence on the SSR [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Associated factors of secondary sex ratio of offspring in assisted reproductive technology: a cross-sectional study in Jilin Province, China

Wang

Liu

Zhang

et al. 2020

BMC Pregnancy Childbirth

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Background The aim of this study was to determine the secondary sex ratio (SSR) of offspring in assisted reproduction technology (ART) in Jilin Province, China, and to analyse the influencing factors associated with SSR. Methods A cross-sectional study of 3833 babies including singletons and twins born to 2990 couples treated by ART between May 2011 and December 2018 was performed. Results The main outcomes of this study were that the SSR of ART babies in Jilin Province was 50.64% and the SSR was associated with fertilization methods (p < 0.05). Comparing to in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) (OR = 0.808, 95%CI: 0.681–0.958) decreased the percentage of male babies. Conclusions This study suggests that the SSR of ART births in Jilin Province was lower than the normal level and ICSI had a significant effect on SSR. Though we need more samples to study in the future, we still need to think about the impact of ICSI on SSR in ART.

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Section: Introductionmentioning

confidence: 99%

Associated factors of secondary sex ratio of offspring in assisted reproductive technology: a cross-sectional study in Jilin Province, China

Wang

Liu

Zhang

et al. 2020

BMC Pregnancy Childbirth

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“…Even though no conclusions has been made, there is a trend of a higher SSR in ART babies following IVF compared with those conceived after intracytoplasmic sperm injection (ICSI). In addition, many studies also demonstrated that the SSR was skewed in favor of males born after blastocyst transfer compared to those born after cleavage-stage embryo transfer in the same time period [8] , [9] , [11] , [12] , [13] .…”

Section: Introductionmentioning

confidence: 99%

Live Birth Sex Ratio after In Vitro Fertilization and Embryo Transfer in China - An Analysis of 121,247 Babies from 18 Centers

Chen

Huang

et al. 2014

PLoS ONE

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In order to study the impact of procedures of IVF/ICSI technology on sex ratio in China, we conducted this multi-center retrospective study including 121,247 babies born to 93,895 women in China. There were 62,700 male babies and 58,477 female babies, making the sex ratio being 51.8% (Male: Female = 107∶100). In univariate logistic regression analysis, sex ratio was imbalance toward females of 50.3% when ICSI was preformed compared to 47.7% when IVF was used (P<0.01). The sex ratio in IVF/ICSI babies was significantly higher toward males in transfers of blastocyst (54.9%) and thawed embryo (52.4%) when compared with transfers of cleavage stage embryo (51.4%) and fresh embryo (51.5%), respectively. Multiple delivery was not associated with sex ratio. However, in multivariable logistic regression analysis after controlling for related factors, only ICSI (adjusted OR = 0.90, 95%CI: 0.88–0.93; P<0.01) and blastocyst transfer (adjusted OR = 1.14, 95% CI: 1.09–1.20; P<0.01) were associated with sex ratio in IVF/ICSI babies. In conclusion, the live birth sex ratio in IVF/ICSI babies was influenced by the use of ICSI, which may decrease the percentage of male offspring, or the use of blastocyst transfer, which may increase the percentage of male offspring.

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“…One report added their nonsignificant outcome from 205 deliveries to outcomes from 6 other reports comprising 86 to 365 babies from 2 clinics representing 1 to 2 years of experience. [ 4 ] The pooled results indicated significantly increased numbers of male babies after blastocyst transfer compared with cleavage-stage embryo transfer (57.3% vs 51.2%, respectively; P = .001). A subsequent meta-analysis including 4 of these studies and a later report of 3 years’ experience at a single center comprising 1284 babies also concluded that significantly more male babies resulted from blastocyst transfer (odds ratio: 1.29; 95% confidence interval: 1.10–1.51).…”

Section: Discussionmentioning

confidence: 99%

Neonate female to male ratio after assisted reproduction following antagonist and agonist protocols

2018

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We retrospectively compared neonatal sex after antagonist- versus long-stimulation protocols followed by fresh in vitro fertilization (IVF) or fresh intracytoplasmic sperm injection (ICSI) with either protocol. We reviewed data for 762 IVF/ICSI cycles in 2015, including 23 IVF procedures. We summarized sex outcomes in the entire cohort, and for the additional subgroups: embryo transfer day and number of embryos transferred, and number of oocytes recovered and maternal age. Among 169 live births for all protocols combined, 50.9% of babies were male, and we saw no difference between the antagonist versus long-stimulation groups (52.3% vs 48.3% male babies, respectively; P = .740). Our results also showed no significant difference in sex proportion when comparing IVF versus ICSI, although a higher proportion of babies were male with the antagonist-ICSI protocol. Differences between the additional subgroups were also neither clinically nor statistically significant.

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Abstract: Although individual studies may lack power to show an altered sex ratio with blastocyst transfer, the combined data presented in this report do suggest that the M/F ratio is higher with blastocyst transfer compared to cleavage stage transfer.

Cited by 47 publications

References 20 publications

Associated factors of secondary sex ratio of offspring in assisted reproductive technology: a cross-sectional study in Jilin Province, China

Associated factors of secondary sex ratio of offspring in assisted reproductive technology: a cross-sectional study in Jilin Province, China

Live Birth Sex Ratio after In Vitro Fertilization and Embryo Transfer in China - An Analysis of 121,247 Babies from 18 Centers

Neonate female to male ratio after assisted reproduction following antagonist and agonist protocols

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