Background: Job satisfaction is an important determinant of workers' motivation, retention, and performance. Each individual working in different segments of the health sector has an impact on the quality and accessibility of the services the health care system provides to the community. Many studies assessed health care workers' job satisfaction. However, the majority of previous studies focused on specific health professionals and facilities. The present study assessed job satisfaction and its associated factors among governmental health workers in West Shoa Zone, Oromia, EthiopiaMethods: An institutional-based cross-sectional study was conducted in West Shoa, Oromia Regional State, Ethiopia, from March 23/2020 to April 15/2020. A total of 429 health workers were identified from type A, B, and C districts. Participants were proportionally allocated for each district and the individual participant was selected using simple random sampling methods. Data was collected using a self-administered structured questionnaire and entered into EpiInfo 7. Data analysis was done using SPSS version 22 software. Mean and/or median were used for continuous variables, whereas; the percentage was used for categorical variables. Bivariate logistic regression analysis was done to assess the association between each independent variable and outcome variable. Multivariate binary logistic regression using adjusted odds ratios and 95% confidence intervals were estimated to assess the strength of association. Results: From the total of 429 study participants, 422 of them were fully responded to the survey with a response rate of 98.3%. The overall level of job satisfaction was 46%. Management. The policy of the worker organization [AOR 0.07, 95% CI: 0.03-.21)], the relationship among the workers [AOR 0.08(95% CI .03-.23], presence of benefit package [AOR 0.07, (95% CI .02-.22], work environment [AOR 0.11, (95% CI: 0. 04-.31], personal growth and development [AOR 0.11 (95% CI: 0.04-.33], supportive supervision from immediate supervisor [AOR 0.04 (95% CI: 0.014-.14] and the nature of work category [AOR 0.03 (95% CI: 0.01-.1] were independently associated with job satisfaction. Conclusions: The overall job satisfaction of health workers in the study area was low. Management and policy of the worker organization, the relationship among the workers, presence of benefit package, work conditioning, personal growth, and development, supportive supervision from immediate supervisor and the nature of work category were among the predictor of job satisfaction.