In this paper, a novel AgCuInTi20-20-4.5 active filler paste for Al2O3 bonding was prepared using the route of vacuum smelting and centrifugal atomizing powder production. The aim of the research was to characterize the AgCuInTi filler paste, and to study the direct brazing of Al2O3 ceramics and copper. The microstructure and melting properties of AgCuInTi powder was analyzed using scanning electron microscopy (SEM) and differential scanning calorimeter (DSC). The brazing process was carried out on vacuum brazing furnace at 700°C for 10 min. The joint microstructures were studied by means of SEM and EDS. The results show that Ti reacted with Al2O3 as the active element at the interface between ceramic and filler metal and finally realizing the metallurgical combination. In participated in the reaction with Ag and Cu. The main products in the brazing seam are TiO2, Cu3TiO4, Cu4Ti, Ag3In and Cu4In based on XRD. The mean value of tensile strength of the brazed joints is approximately 89 MPa. The studied AgCuInTi possesses excellent joining characteristics with several metallic and ceramic materials.