Joint-Attention and the Social Phenotype of School-Aged Children with ASD

Mundy, Peter; Novotny, Stephanie; Swain-Lerro, Lindsey; McIntyre, Nancy S.; Zajic, Matt; Oswald, Tasha M.

doi:10.1007/s10803-017-3061-0

Cited by 20 publications

(13 citation statements)

References 64 publications

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“…However, even in the vehicle-treated PON1 -/pups' affiliative behavior in the NOP was significantly lower than that of the PON1 +/+ mice, suggesting that this genotype has less social affiliation than PON1 +/+ mice. Early assessment of social deficits in pups bolsters the burgeoning research in infants focusing on early diagnosis of ASD via measures such as gaze fixation [63], auditory evoked potentials [64] or joint attention [65]. NOP was reduced in rat pups by prenatal stress to the dam [55,66] and enhanced in male, but not female mouse pups with the Chd8 +/N2373K mutation [67].…”

Section: Discussionmentioning

confidence: 99%

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

et al. 2020

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The levels and activity of the enzyme paraoxonase 1 affect the vulnerability to the teratogenic effects of organophosphate pesticides. Mutant mice lacking the gene for paraoxo-nase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and were hypothesized to be more vulnerable to social behavior deficits induced by exposure to chlorpyrifos during gestation. Three experiments were performed comparing PON1-/mice to PON1 +/+ mice born to dams treated with 0.5 mg/kg chlorpyrifos or cornoil vehicle on gestational days 12-15. Chlofpyrifos-exposed male PON1-/mouse pups had delayed development of reflexes in in the first experiment. In the second experiment, adult male and female PON1-/mice and the female PON1 +/+ mice all displayed lower social preference than the male vehicle-treated PON1 +/+ mice. The PON1-/mice and the female PON1 +/+ mice displayed lower social preference compared to the PON1 +/+ male mice. Male adult mice that had been exposed in utero to chlorpyrifos showed less conditioned social preference regardless of genotype. In the third study, the delayed reflex development was replicated in male and female PON1-/mice, but chlorpyrifos did not augment this effect. Nest Odor Preference, a test of early social attachment to dam and siblings, was lower in PON1-/mouse pups compared to PON1 +/+ pups. This study shows for the first time that PON1-/mice have a behavioral phenotype that indicates impaired reflex development and social behavior. Chlorpyrifos exposure during gestation tended to augment some of these effects.

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Section: Discussionmentioning

confidence: 99%

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

et al. 2020

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“…The pass/fail scoring of each item contributes to the feasibility and likely the reliability of scoring during administration, but this scoring does not provide information about the quality of joint attention skills demonstrated. To supplement the JA Protocol data with parent reported data about the frequency of JA behaviors demonstrated by the child in various environments, we recommend the Childhood Joint-Attention Rating Scale (C-JARS; Mundy et al, 2017). Furthermore, the psychometric samples used in this study were not nationally representative and included limited parental education, racial, and socioeconomic diversity.…”

Section: Discussionmentioning

confidence: 99%

An Initial Psychometric Evaluation of the Joint Attention Protocol

Nowell

Watson

Faldowski

et al. 2018

J Autism Dev Disord

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The goal of this paper is to examine the psychometric properties of a live-coded behavioral measure of joint attention, the Attention-Following and Initiating Joint Attention Protocol (JA Protocol), in order to assist researchers and clinicians in identifying when this measure may meet their joint attention assessment needs. Data from 260 children with autism spectrum disorder, developmental delay, or typical development between the ages of 2 and 12 years were used to evaluate this measure using quality standards for measurement. Overall, the JA Protocol demonstrated good psychometric properties. Recommendations and limitations for use of this measure based on psychometric analysis results are reported.

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“…Thus, the lack of females within the ASD sample prevents us from identifying what their pattern of EEG/eye-tracking change would be. Recent literature that specifically explored the JA skills in children with ASD suggested no gender differences between girls and boys evaluated through a structured session of play interaction 56 , or a parent report scale focused on JA 57 . We can therefore speculate that females with ASD, carefully matched on developmental and diagnostic variables with the males recruited in this study, would have the same pattern of EEG/eye-tracking response of JA.…”

Section: Discussionmentioning

confidence: 99%

An integrated EEG and eye-tracking approach for the study of responding and initiating joint attention in Autism Spectrum Disorders

Billeci

Narzisi

Tonacci

et al. 2017

Sci Rep

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Autism Spectrum Disorders (ASD) are characterised by impairment in joint attention (JA), which has two components: the response to JA and the initiation of JA. Literature suggests a correlation between JA and neural circuitries, although this link is still largely unexplored in ASD. In this pilot study, we aimed at investigating the neural correlates of responding and initiating JA in high-functioning children with ASD and evaluating the changes in brain function and visual pattern after six months of rehabilitative treatment using an integrated EEG/eye-tracking system. Our results showed that initiating and responding JA subtend both overlapping (i.e. frontal and temporal) and specialized (i.e. parietal for responding JA and occipital for initiating JA) neural circuitries. In addition, in a subgroup of subjects, we observed trends of changes in both brain activity and connectivity after rehabilitative treatment in both the two tasks, which were correlated with modifications in gaze measures. These preliminary results, if confirmed in a larger sample, suggest the feasibility of using the proposed multimodal approach to characterise JA-related brain circuitries and visual pattern in ASD individuals and to monitor longitudinal changes in response to rehabilitative intervention.

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Joint-Attention and the Social Phenotype of School-Aged Children with ASD

Cited by 20 publications

References 64 publications

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

An Initial Psychometric Evaluation of the Joint Attention Protocol

An integrated EEG and eye-tracking approach for the study of responding and initiating joint attention in Autism Spectrum Disorders

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