Joint effects of risk factors on adverse events associated with adult blood donations

Abstract

The process for blood donation is considered safe, but some adverse events have been reported. Risk factors for adverse events were assessed in this study. A retrospective case-control study was conducted to investigate the risk factors for adverse events after blood donation between 2010 and 2013. Variables such as gender, age, body mass index (BMI), donation status, donation volume, donation site, pre-donation systolic blood pressure (SBP), and pre-donation diastolic blood pressure were compared between donors with and without adverse events. Multiple logistic regression analysis was performed to assess the joint effects of age, gender, and donation status on adverse events. The incidence of adverse events among adult blood donations was 1287/1,253,678 (0.1%). On multivariate logistic regression analysis, blood donors aged <35 years (odds ratio [OR], 2.99, 95% confidence interval [CI], 2.57–3.48), of female gender (OR, 3.30, 95% CI, 2.62–4.15), and with first-time donor status (OR, 6.40, 95% CI, 5.17–7.93), donation of 500 mL (OR, 2.22, 95% CI, 1.83–2.69), predonation SBP <124 mm Hg (OR, 1.25, 95% CI,1.05–1.48) and BMI <24 kg/m2 (OR, 1.67, 95% CI, 1.42–1.96) were associated with increased likelihood of adverse event. Further analysis with joint effects method revealed that first-time female donors aged <35 years are associated with the highest odds of adverse events when compared with repeat male donors aged ≧35 years (OR, 100.57, 95% CI, 48.45–208.75). The findings of our study should prove useful in identifying donors at risk and planning appropriate strategies for the prevention of adverse effects.

Impact of regular blood donation on the human body; donors’ perspective. Donors’ opinion on side effects of regular blood donation on human body

“…They more often expressed the opinion that frequent blood donation has no negative consequences (p < 0.05) [27]. Wang et al revealed that only 0.1% of blood donors had side effects after donating blood [28] and Orru et al indicated that only 0.04% of donors required hospitalization [29]. It is worth noting that in the study by Kumari et al, 92.38% of student-donors experienced only positive emotions [30].…”

Factors associated with first‐time and repeat blood donation: Adverse reactions and effects on donor behavior

“…Voluntary, uncompensated, eligible blood donors are the major source of blood products; therefore, the donor collection centers have a dual mission to maintain a safe and adequate supply for patients and to ensure the safety of blood donors. Blood donation is considered a safe and well‐tolerated procedure; however, uncommon adverse reactions (AR) do occur, causing mild discomfort and—exceedingly rarely—serious events 2–4 . Much attention has been devoted to the better understanding of groups at high risk for AR 4–6 and the prevention of AR 7–9 …”

“…Blood donation is considered a safe and well-tolerated procedure; however, uncommon adverse reactions (AR) do occur, causing mild discomfort andexceedingly rarely-serious events. [2][3][4] Much attention has been devoted to the better understanding of groups at high risk for AR [4][5][6] and the prevention of AR. [7][8][9] The strongest factors associated with AR are first-time donation status, female gender, younger age, and lower estimated blood volume (EBV).…”

Machine learning-based prediction of fainting during blood donations using donor properties and weather data as features

“…Psychological factors such as fear play a significant role in whether blood donation incidents occur. This often affects young first-time donors [ 10 , 11 ].Vasovagal reactions are the most common adverse events during or after allogeneic blood donations. Minor symptomatic (presyncope) reactions result in up to 2.72% of donations [ 12 ], and major reactions with injury were reported in up to 0.09% of donations [ 13 ].…”