Joint myocardial T1 and T2 mapping using a combination of saturation recovery and T2‐preparation

Akçakaya, Mehmet; Weingärtner, Sebastian; Basha, Tamer; Roujol, Sébastien; Bellm, Steven; Nezafat, Reza

doi:10.1002/mrm.25975

Cited by 65 publications

(90 citation statements)

References 39 publications

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“…cMRF is one of several techniques proposed for joint myocardial T 1 and T 2 mapping . Recently, CMR multitasking has been reported for generating motion‐resolved T 1 and T 2 maps with a scan time of 88 s per slice .…”

Section: Discussionmentioning

confidence: 99%

Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction

Hamilton

Jiang

et al. 2018

NMR in Biomedicine

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This study introduces a technique for simultaneous multislice (SMS) cardiac magnetic resonance fingerprinting (cMRF), which improves the slice coverage when quantifying myocardial T1, T2, and M0. The single‐slice cMRF pulse sequence was modified to use multiband (MB) RF pulses for SMS imaging. Different RF phase schedules were used to excite each slice, similar to POMP or CAIPIRINHA, which imparts tissues with a distinguishable and slice‐specific magnetization evolution over time. Because of the high net acceleration factor (R = 48 in plane combined with the slice acceleration), images were first reconstructed with a low rank technique before matching data to a dictionary of signal timecourses generated by a Bloch equation simulation. The proposed method was tested in simulations with a numerical relaxation phantom. Phantom and in vivo cardiac scans of 10 healthy volunteers were also performed at 3 T. With single‐slice acquisitions, the mean relaxation times obtained using the low rank cMRF reconstruction agree with reference values. The low rank method improves the precision in T1 and T2 for both single‐slice and SMS cMRF, and it enables the acquisition of maps with fewer artifacts when using SMS cMRF at higher MB factors. With this technique, in vivo cardiac maps were acquired from three slices simultaneously during a breathhold lasting 16 heartbeats. SMS cMRF improves the efficiency and slice coverage of myocardial T1 and T2 mapping compared with both single‐slice cMRF and conventional cardiac mapping sequences. Thus, this technique is a first step toward whole‐heart simultaneous T1 and T2 quantification with cMRF.

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Section: Discussionmentioning

confidence: 99%

Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction

Hamilton

Jiang

et al. 2018

NMR in Biomedicine

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“…T 1 and T 2 values were measured in region of interests (ROIs) for the phantoms and in vivo experiments. Mean values within the ROI were used to assess accuracy whereas the SD within the ROI (spatial variability) was considered as an indication of the mapping precision in phantom and used as a surrogate for precision in the healthy myocardium measurements . Accuracy of T 1 and T 2 water Dixon‐cMRF was assessed in the standardized T 1 /T 2 phantom study through lines of best fit, determination coefficient, and normalized RMSE (NRMSE) with respect to reference IRSE and MESE measurements.…”

Section: Methodsmentioning

confidence: 99%

Water–fat Dixon cardiac magnetic resonance fingerprinting

Jaubert

Cruz

Bustin

et al. 2019

Magnetic Resonance in Med

101

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Purpose Cardiac magnetic resonance fingerprinting (cMRF) has been recently introduced to simultaneously provide T1, T2, and M0 maps. Here, we develop a 3‐point Dixon‐cMRF approach to enable simultaneous water specific T1, T2, and M0 mapping of the heart and fat fraction (FF) estimation in a single breath‐hold scan. Methods Dixon‐cMRF is achieved by combining cMRF with several innovations that were previously introduced for other applications, including a 3‐echo GRE acquisition with golden angle radial readout and a high‐dimensional low‐rank tensor constrained reconstruction to recover the highly undersampled time series images for each echo. Water–fat separation of the Dixon‐cMRF time series is performed to allow for water‐ and fat‐specific T1, T2, and M0 estimation, whereas FF estimation is extracted from the M0 maps. Dixon‐cMRF was evaluated in a standardized T1–T2 phantom, in a water–fat phantom, and in healthy subjects in comparison to current clinical standards: MOLLI, SASHA, T2‐GRASE, and 6‐point Dixon proton density FF (PDFF) mapping. Results Dixon‐cMRF water T1 and T2 maps showed good agreement with reference T1 and T2 mapping techniques (R2 > 0.99 and maximum normalized RMSE ~5%) in a standardized phantom. Good agreement was also observed between Dixon‐cMRF FF and reference PDFF (R2 > 0.99) and between Dixon‐cMRF water T1 and T2 and water selective T1 and T2 maps (R2 > 0.99) in a water–fat phantom. In vivo Dixon‐cMRF water T1 values were in good agreement with MOLLI and water T2 values were slightly underestimated when compared to T2‐GRASE. Average myocardium septal T1 values were 1129 ± 38 ms, 1026 ± 28 ms, and 1045 ± 32 ms for SASHA, MOLLI, and the proposed water Dixon‐cMRF. Average T2 values were 51.7 ± 2.2 ms and 42.8 ± 2.6 ms for T2‐GRASE and water Dixon‐cMRF, respectively. Dixon‐cMRF FF maps showed good agreement with in vivo PDFF measurements (R2 > 0.98) and average FF in the septum was measured at 1.3%. Conclusion The proposed Dixon‐cMRF allows to simultaneously quantify myocardial water T1, water T2, and FF in a single breath‐hold scan, enabling multi‐parametric T1, T2, and fat characterization. Moreover, reduced T1 and T2 quantification bias caused by water–fat partial volume was demonstrated in phantom experiments.

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“…Cardiac MRF is one of several techniques that can perform simultaneous T 1 and T 2 mapping in the myocardium, including CAIBIRIA (23), QALAS (24), and joint T 1 -T 2 mapping with T 2 -preparation and either saturation (25) or inversion pulses (26). Although the use of interleaved inversions and T 2 preparations is used in other mapping sequences, the MRF paradigm is unique in several ways.…”

Section: Discussionmentioning

confidence: 99%

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

et al. 2017

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Purpose-To introduce a 2D MR Fingerprinting technique for quantification of T 1 , T 2 , and M 0 in myocardium.Methods-An ECG-triggered MR Fingerprinting (MRF) method is introduced for mapping myocardial T 1 , T 2 , and M 0 during a single breathhold in as short as four heartbeats. The pulse sequence employs variable flip angles, repetition times, inversion recovery times, and T 2 preparation dephasing times. A dictionary of possible signal evolutions is simulated for each scan that incorporates the subject's unique variations in heart rate. Aspects of the sequence design were explored in simulations, and the accuracy and precision of cardiac MRF were assessed in a phantom study. In vivo imaging was performed at 3T in eleven volunteers to generate native parametric maps.Results-T 1 and T 2 measurements from the proposed cardiac MRF sequence correlated well with standard spin echo measurements in the phantom study (R 2 >0.99). A Bland-Altman analysis revealed good agreement for myocardial T 1 measurements between MRF and MOLLI (bias 1ms, 95% limits of agreement −72 to 72ms) and T 2 measurements between MRF and T 2 -prepared bSSFP (bias −2.6ms, 95% limits of agreement −8.5 to 3.3ms). Conclusions-MRFcan provide quantitative single slice T 1 , T 2 , and M 0 maps in the heart within a single breathhold.

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Joint myocardial T₁ and T₂ mapping using a combination of saturation recovery and T₂‐preparation

Cited by 65 publications

References 39 publications

Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction

Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction

Water–fat Dixon cardiac magnetic resonance fingerprinting

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

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Joint myocardial T1 and T2 mapping using a combination of saturation recovery and T2‐preparation

Cited by 65 publications

References 39 publications

Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction

Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction

Water–fat Dixon cardiac magnetic resonance fingerprinting

MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density

Contact Info

Product

Resources

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Joint myocardial T₁ and T₂ mapping using a combination of saturation recovery and T₂‐preparation

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density