Multi-numerology (MN) providing a flexible transmission frame structure has attracted a considerable attention for supporting abundant services for beyond fifth-generation (B5G) networks. However, mobility induces severe performance degradation under different numerologies including temporal and spectral fluctuation, which is not well-investigated in existing literature. We have conceived an MN-enabled energy efficiency (EE) problem aiming for alleviating mobility-and MN-induced interferences through moderate power and sub-carrier assignment, while considering quality-of-service (QoS) and latency requirements for different services. We propose a multi-numerology based power and resource block allocation (MNPRA) scheme considering time-/frequency-division (TD/MD) based MN leveraging temporal and spectral features among numerologies. The original non-solvable problem is theoretically transformed into a convex one by employing Dinkelbach process, Taylor approximation and difference of two concave functions (D.C.). Convergence of proposed MNPRA scheme is analyzed and verified by simulations. In simulation results, we have evaluated MNPRA under different service demands, user velocities and MN types. Our proposed scheme outperforms the conventional single-numerology framing and existing methods in open literature, which results in performances of higher EE as well as of lower throughput/delay outage probability.