Joint role of non-HDL cholesterol and glycated haemoglobin in predicting future coronary heart disease events among women with type 2 diabetes

Schulze, Matthias B.; Shai, Iris; Manson, JoAnn E.; Li, T.; Rifai, Nader; Jiang, Rui; Hu, Frank B.

doi:10.1007/s00125-004-1593-2

Cited by 38 publications

(38 citation statements)

References 23 publications

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“…Another study on female type 2 diabetic patients has revealed that association between non-HDL cholesterol and CHD risk is apparent in patients with elevated TG [43]. Moreover, significantly high serum TG levels have been found in diabetic patients with CHD as compared to non-diabetic patients [34].…”

Section: Discussionmentioning

confidence: 99%

Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

2007

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Impaired lipid metabolism resulting from uncontrolled hyperglycaemia has been implicated in cardiovascular complications in diabetes patients. The aim of this study was to examine the impact of glycaemic control on the lipid profile of diabetic patients. We also determined the ability of glycated haemoglobin (HbA(1c)) as an indirect marker of dyslipidaemia. A total of 1011 type 2 diabetic patients (males, 574; females, 437; mean age, 59.76 years) were included in this study. Venous blood samples were collected from all the subjects after at least 8 h fasting. The sera were analysed for HbA(1c), fasting blood glucose (FBG), total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL). The levels of HbA(1c), FBG and LDL did not differ significantly between males and females. Female patients showed significantly higher serum cholesterol and HDL but significantly lower TG levels as compared to males. There was a highly significant correlation between HbA(1c) and FBG. Both HbA(1c) and FBG exhibited direct correlations with cholesterol, TG and LDL and inverse correlation with HDL; the magnitude of significance for all these lipid parameters being greater with HbA(1c) than FBG. There was a linear relationship between HbA(1c) and dyslipidaemia. The levels of serum cholesterol and TG were significantly higher and of HDL significantly lower in patients with worse glycaemic control as compared to patients with good glycaemic control. The findings of this study clearly indicate that HbA(1c) is not only a useful biomarker of long-term glycaemic control but also a good predictor of lipid profile. Thus, monitoring of glycaemic control using HbA(1c) could have additional benefits of identifying diabetic patients who are at a greater risk of cardiovascular complications.

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Section: Discussionmentioning

confidence: 99%

Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

2007

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“…The Strong Heart Study, which addressed only American Indians, showed that non-HDL-cholesterol is a better predictor of cardiovascular morbidity than LDL-cholesterol [17]. Two further studies of people with diabetes in the USA, who were free of cardiovascular disease at baseline, comprised 921 female nurses aged <65 years [18] and 746 male health professionals aged 46-81 years [19]. In both studies, non-HDL-cholesterol was considered a better predictor of cardiovascular disease than ApoB.…”

Section: Discussionmentioning

confidence: 99%

“…Since that time, a substantial number of reports have indicated that ApoB and non-HDL-cholesterol are better predictors than LDL-cholesterol in people with diabetes [16][17][18][19]. Few studies have been conducted, however, to compare non-HDL-cholesterol with ApoB [18,19]; the studies that have been reported were restricted to North America, and the results were mixed. It would be misleading to generalise the findings to other populations, for a number of reasons.…”

Section: Introductionmentioning

confidence: 99%

Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato study

et al. 2006

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Aims/hypothesis: Measurement of plasma apolipoprotein (Apo) B may improve prediction of cardiovascular risk, as it provides a measure of the total number of atherogenic particles. The aim of this population-based study was to compare the association of non-HDLcholesterol, ApoB and the ApoB:ApoA-I ratio with cardiovascular mortality in people with type 2 diabetes. Subjects and methods: We assessed the association of lipids, lipoprotein lipids and apolipoproteins with 11-year mortality from cardiovascular disease in the populationbased cohort of the Casale Monferrato Study (1,565 people with diabetes; median age 68.9 years), and determined the effect of age (≤70 and >70 years) on these relationships. Results: On the basis of 341 deaths from cardiovascular disease in 10,809 person-years of observation, there was a decreasing trend in risk adjusted for multiple factors across quartiles of total cholesterol, and LDL-and non-HDL-cholesterol in people aged >70 years, but no trend in those aged ≤70 years. Age did not affect the protective effect of HDL-cholesterol. ApoB and ApoB:ApoA-I were associated with outcome in people in both age groups independently of non-HDLcholesterol. After adjustment for multiple factors, including non-HDL-cholesterol, the hazard ratios for ApoB: ApoA-I in the upper vs lower quartile were 2.98 (95% CI 1.15-7.75; p for trend=0.009) for people aged ≤70 years and 1.94 (95% CI 1.20-3.13; p for trend=0.003) for those aged >70 years. Conclusions/interpretation: In this cohort of Mediterranean subjects with diabetes, ApoB and the ApoB:ApoA-I ratio were associated with cardiovascular disease mortality independently of non-HDLcholesterol. Our findings support the recommendation that ApoB and ApoA-I should be measured routinely in all people with diabetes, particularly in the elderly.

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“…In Australia, diabetes is the sixth highest cause of death by disease and the fastest growing chronic illness (Chittleborough et al, 2007). Diabetic patients are twice as likely to have high blood pressure, cholesterol disturbances and heart disease (Schulze et al, 2004). In 2013, it was estimated that one in four Australian adults has either diabetes or pre-diabetes, with one person being diagnosed every 5 min (Schmid et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Novel chenodeoxycholic acid–sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. Anin vitrostudy

Mooranian¹,

Negrulj²,

Mikov³

et al. 2015

Journal of Microencapsulation

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Joint role of non-HDL cholesterol and glycated haemoglobin in predicting future coronary heart disease events among women with type 2 diabetes

Cited by 38 publications

References 23 publications

Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato study

Novel chenodeoxycholic acid–sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. Anin vitrostudy

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