Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

Khan, Haseeb A.; Sobki, Samia H.; Khan, Shaukat

doi:10.1007/s10238-007-0121-3

Cited by 182 publications

(177 citation statements)

References 42 publications

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“…[6] Results of our study shows that the level of LDL, TC & TG were significantly higher in Type 2 diabetics, which is in accordance with the study conducted by Wexler et al [7] Diabetic patients with elevated HbA1c and altered Lipid profile can be considered as a very high risk group for severe complications. Improving glycemic control can substantially reduce the risk in diabetic patients.…”

Section: Discussionsupporting

confidence: 92%

Correlation between Glycated hemoglobin and Lipid profile in Type 2 Diabetic population of district Meerut, U.P.

Taliyan¹,

Nagtilak²,

Parashar³

et al. 2016

Int J of Biomed & Adv Res

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Background: The Type 2 diabetes mellitus is becoming more and more prevalent in our country India and it is estimated that approximately around 2% of the Indian population i.e around 15 million peoples are suffering from this disease and Glycated hemoglobin (HbA1c) is routinely used as a diagnostic tool for screening and measuring long term control in diabetic patient. Aim: The study was planned to observe the relationship among Glycated hemoglobin (HbA1c), Fasting blood sugar and Lipid profile in Type 2 diabetics of western U.P population. Material and Methods: Data of around 92 males and 112 females, from the age group of 25 to 55 years were selected from December 2014 to July 2016 in a cross sectional manner. Blood sample (3ml) was collected from each subject. Serum was separating by centrifuging blood at 3000 rpm for 10 min. Fasting blood sugar and Lipid profile were estimated by Vitros 250 auto analyzer using readymade dry chemistry kits from Ortho Clinical diagnostics, Johnson & Johnson, USA and HbA1c with kit based method. Result: Mean value of HbA1c in control subjects was 4.62± 0.18 and 5.78± 0.19 in diabetic subjects, HbA1c values were significantly higher in Diabetic subjects (<0.001) as compared to control subjects. The mean value of FBS in Diabetic subjects was 115.72± 3.83 and 92.33± 3.61 in control subjects. Also, FBS mean value was found to be significantly lower in control group (<0.001) as compared to Diabetic subjects. Conclusion: Our study demonstrates that, altered Lipid profile has been associated with elevated levels of Fasting blood glucose. Thus, the adverse effect of hyperglycemia and associated dyslipidemia must not be overlooked in Diabetic subjects.

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Section: Discussionsupporting

confidence: 92%

Correlation between Glycated hemoglobin and Lipid profile in Type 2 Diabetic population of district Meerut, U.P.

Taliyan¹,

Nagtilak²,

Parashar³

et al. 2016

Int J of Biomed & Adv Res

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“…These findings were consistent with results obtained by Khan [11] and Khan et al [12] These findings suggest that HbA 1c can provide valuable supplementary information about the extent of circulating lipids besides its primary role in monitoring long-term glycemic control. Increase in TG and decline in HDL with HbA 1c rise shows the impact of glycemic control on lipoprotein levels and that hyperlipidemia of diabetic patients may be correctable by improving blood sugar.…”

Section: Discussionsupporting

confidence: 93%

A comparative study of lipid profile, body mass index, and waist circumference among Type 2 diabetes mellitus patients with poor and good metabolic control and normal age-matched control group

Menon¹,

Venugopal²

2017

Natl J Physiol Pharm Pharmacol

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Background: Prevalence of dyslipidemia is very common in Type 2 diabetes mellitus (DM), and lipid abnormalities are likely to play an important role in the development of the atherosclerotic vascular disease. Type 2 diabetic patients are obese, and obesity as an independent risk factor for diabetes also complicates the management and exacerbates the metabolic abnormalities in diabetes. Aims and Objectives: To compare the lipid profile, body mass index (BMI), and waist circumference (WC) in Type 2 diabetic patients with poor and good metabolic controls with that of normal controls and to study the correlation between glycosylated hemoglobin (HbA 1c ) values and triglycerides (TG), high-density lipoprotein (HDL) in patients with Type 2 DM. Materials and Methods: The descriptive comparative study group of 150 subjects was divided into three groups based on HbA 1c values which included Type 2 diabetic patients with poor metabolic control, good metabolic control, and normal age-matched controls. Results: There is a significant increase in the mean levels of total cholesterol, TG, low-density lipoprotein (LDL), and Very low density lipoproteins (VLDL) values in diabetic patients with both poor metabolic control and good metabolic control when compared to normal controls. There is a significant decrease in mean HDL values and significant elevation of mean waist circumference and BMI values in both male and female diabetics with poor and good metabolic controls when compared to normal controls. Highly significant positive correlation was obtained between HbA 1c and TG and a negative correlation between HbA 1c and HDL. Conclusion: Increase in TG and decline in HDL with HbA 1c rise shows the impact of glycemic control on lipoprotein levels. Majority of diabetic patients were overweight and had abdominal adiposity. Good metabolic control of hyperglycemia will prevent alteration of lipid metabolism helping in better prognosis and preventing manifestations of vascular and typical secondary complications.

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“…Our findings in this study are concomitant with Khan et al who also reported a direct correlation between FBS and HbA1c with TC, TG and LDL-C and inverse correlation with HDL-C. 18 Mahato et al also observed significant correlations between HbA1c with TC, LDL-C and LDL-C/HDL-C ratio. 19 Ramona et al reported direct and significant correlation between HbA1c with TC, TG and LDL-C, and reverse correlation with HDL-C. 20 In our study, correlation of HbA1c with the lipid profile was even more compared to FBS and PPBS.…”

Section: Discussionsupporting

confidence: 91%

Correlation between glycemic parameters and lipid profile in type 2 diabetic patients attending tertiary care centre in central region of Nepal

Sapkota

Thapa

2017

J Chitwan Med Coll

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Background: Diabetes Mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia with type 2 DM accounting for more than 90% of adult diabetes cases worldwide. Hyperglycemia in type 2 DM is strongly linked with dyslipidemia which in turn increases risk for development of cardiovascular diseases. This study aimed to determine the correlation between glycemic parameters (fasting blood sugar-FBS, postprandial blood sugar-PPBS and glycated hemoglobin-HbA1c) and serum lipid profile in type 2 diabetic patients. Methods: Altogether 160 type 2 diabetic patients (Male=80 and Female=80) aged between 30-70 years visiting Chitwan Medical College Teaching Hospital (CMCTH) for their routine medical check-up were included in this study. Data were collected using preformed set of questionnaires and biochemical data were obtained from the laboratory analysis of the patient's blood samples. Statistical analysis was done with SPSS version 20.0. Results: Hyperglycemia was significant as evident by elevated FBS, PPBS and HbA1c. Also, the serum lipid profile was deranged with elevated TC, TG, LDL, VLDL and lowered HDL levels suggestive of dyslipidemia. There was a Direct and significant correlation of glycemic parameters (FBS, PPBS and HbA1c) with total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) while the correlation with high density lipoprotein cholesterol (HDL-C) was just reverse. Conclusion: Chronic hyperglycemia in type 2 DM is associated with dyslipidemia which further exposes risk for the development of cardiovascular diseases. HbA1c, being the gold standard for the assessment of glycaemia is also the better predictor of dyslipidemia in type 2 diabetic patients.

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Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

Cited by 182 publications

References 42 publications

Correlation between Glycated hemoglobin and Lipid profile in Type 2 Diabetic population of district Meerut, U.P.

Correlation between Glycated hemoglobin and Lipid profile in Type 2 Diabetic population of district Meerut, U.P.

A comparative study of lipid profile, body mass index, and waist circumference among Type 2 diabetes mellitus patients with poor and good metabolic control and normal age-matched control group

Correlation between glycemic parameters and lipid profile in type 2 diabetic patients attending tertiary care centre in central region of Nepal

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