Judy C. Pearson, 2003 President, National Communication Association

Pearson, Judy C.

doi:10.1080/15358590600918839

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Default values for physical properties and material costs were used when available. When unavailable, economic data was sourced through a combination of MilliporeSigma communications (Table S1) and bulk price estimation 42,43 . SuperPro's 2019 economic model was used for economic evaluations.…”

Section: Methodsmentioning

confidence: 99%

Economic simulation of batch and continuous aqueous two‐phase purification for viral products

Nold,

Pearson,

Heldt

2023

Biotechnology Progress

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Vaccine manufacturing strategies that lower capital and production costs could improve vaccine access by reducing the cost per dose and encouraging localized manufacturing. Continuous processing is increasingly utilized to drive lower costs in biological manufacturing by requiring fewer capital and operating resources. Aqueous two‐phase systems (ATPS) are a liquid–liquid extraction technique that enables continuous processing for viral vectors. To date, no economic comparison between viral vector purifications using traditional methods and ATPS has been published. In this work, economic simulations of traditional chromatography‐based virus purification were compared to ATPS‐based virus purification for the same product output in both batch and continuous modes. First, the modeling strategy was validated by re‐creating a viral subunit manufacturing economic simulation. Then, ATPS capital and operating costs were compared to that of a traditional chromatography purification at multiple scales. At all scales, ATPS purification required less than 10% of the capital expenditure compared to chromatography‐based purification. At an 11 kg per year production scale, the ATPS production costs were 50% less than purification with chromatography. Other chromatography configurations were explored, and may provide a production cost benefit to ATPS, but the purity and recovery were not experimentally verified. Batch and continuous ATPS were similar in capital and production costs. However, manual price adjustments suggest that continuous ATPS plant‐building costs could be less than half that of batch ATPS at the 11 kg per year production scale. These simulations show the significant reduction in manufacturing costs that ATPS‐based purification could deliver to the vaccine industry.

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Section: Methodsmentioning

confidence: 99%

Economic simulation of batch and continuous aqueous two‐phase purification for viral products

Nold,

Pearson,

Heldt

2023

Biotechnology Progress

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“…Pearson C., Turner H. Y Todd-Mancillas W afirman "si bien el sexo se refiere a una categoría biológica determinada por cromosomas portadores de información genética, que proporciona diferentes caracteres sexuales en los individuos (masculino y femenino). En el caso del genero, cuando se habla de él nos referimos a un conjunto de conductas aprendidas culturalmente como sujeto masculino y femenino" [8].…”

Section: Sexo Y Género Bajo Un Mismo Sentido Conceptos Distintosunclassified

La construcción de personajes en el videojuego SIMS 2

Guardia

Molano

2012

icono14

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“…tion model of Pearson (2006) since this provides all the necessary features we require, and, in later work, can easily be compared and contrasted with Pearson's parallel bright galaxy evolution model. The model we use is based on an evolving, typedependent, far-infrared luminosity function which makes use of a set of 11 optical-to-submm template SEDs.…”

Section: The Far-ir Skymentioning

confidence: 99%

“…We thus find that blind, blank-field spectral surveys are capable not only of detecting sources well below the confusion limit but of obtaining their redshifts at the same time. Early analysis suggests we can distinguish between different luminosity evolution models (the burst and bright models from Pearson (2006)) with a survey 10'x10' or less in size using these techniques. This is something not possible using broadband number counts.…”

Section: Fig 2 Source Detected In Line Below Confusion Limitmentioning

confidence: 99%

Dissecting the cosmic infrared background with 3D instruments

Clements¹,

Isaak²,

Madden³

et al. 2007

A&A

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Context. The cosmic infrared background (CIB) consists of emission from distant, dusty, star-forming galaxies. Energetically, the CIB is very important as it contains as much energy as the extragalactic optical background. The nature and evolutionary status of the objects making up the background are, however, unclear. Aims. The CIB peaks at ∼150 µm, and as such is most effectively studied from space. The limited apertures of space-borne telescopes set the angular resolution that can be attained, and so even Herschel, with its 3.5 m diameter, will be confusion-limited at this wavelength at ∼5 mJy. The bulk of the galaxies contributing to the CIB are fainter than this, so it is difficult to study them without interferometry. Here we present the results of a preliminary study of an alternative way of probing fainter than the continuum confusion limit using far-IR imaging spectroscopy. An instrument capable of such observations is being planned for SPICA -a proposed Japanese mission with an aperture equivalent to that of Herschel and more than 2 orders of magnitude more sensitive. Methods. In this paper we investigate the potential of imaging spectrometers to break the continuum confusion limit. We have simulated the capabilities of a spectrometer with modest field of view (2 × 2 ), moderate spectral resolution (R ∼ 1-2000) and high sensitivity. Results. We find that such an instrument is capable of not only detecting line emission from sources with continuum fluxes substantially below the confusion limit, but also of determining their redshifts and, where multiple lines are detected, some emission line diagnostics. Conclusions. 3-D imaging spectrometers on cooled far-IR space telescopes will be powerful new tools for extragalactic far-IR astronomy.

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Judy C. Pearson, 2003 President, National Communication Association

Cited by 6 publications

References 26 publications

Economic simulation of batch and continuous aqueous two‐phase purification for viral products

Economic simulation of batch and continuous aqueous two‐phase purification for viral products

La construcción de personajes en el videojuego SIMS 2

Dissecting the cosmic infrared background with 3D instruments

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