"Just Make It Lower" Is an Alternative Strategy of Lipid-Lowering Therapy With Statins in Japanese Patients - LDL-Cholesterol: The Lower, the Better; Is It True for Asians? (Con) -

Effect of Statin Treatment and Low-Density Lipoprotein-Cholesterol on Short-Term Mortality in Acute Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention – Multicenter Registry From Tokyo CCU Network Database –

“…15 Therefore, the concept of "the lower, the better" could be important for patients with very high cardiovascular risk not only in Western countries but also in Asian countries. 16 The present study showed that statin treatment was significantly associated with better short-term outcome in AMI patients undergoing primary PCI, even in patients with low LDL-C. This is compatible with previous results.…”

Impact of the Low- to High-Density Lipoprotein Cholesterol Ratio on Composition of Angiographically Ambiguous Left Main Coronary Artery Plaque

“…24, 25 It is well established that high serum levels of LDL-C constitute a strong predictor of CHD, and that LDL-C-lowering therapy reduces CHD. 26 The LDL-C/HDL-C ratio was found to be a more accurate in determining CHD risk, compared to LDL-C or HDL-C alone. 8, 27 Several studies have demonstrated that a 1-unit increase in the LDL-C/HDL-C ratio is equivalent to a 53-75% increase in the risk of myocardial infarction.…”

Statin Use in Patients with Diabetes and Kidney Disease: The Japanese Experience

“…As with the previous JAS guidelines of 2007, an LDL-C goal of ＜120 mg/dL has been set for high-risk primary prevention patients, with an LDL-C goal of ＜100 mg/dL recommended for secondary prevention patients. Whether more stringent, Western-style lipid targets are required in Japan, and whether intensive treatment to achieve these goals would provide a clear clinical benefit in Japanese patients, is the subject of much debate 66,67) . The proportion of secondary prevention patients who reach recommended lipid goals in Japan is traditionally very low (20%-40%) 68,69) .…”