Juvenile Friends, Behavior, and Immune Responses to Separation in Bonnet Macaque Infants

Boccia, Maria L.; Scanlan, James M.; Laudenslager, Mark L.; Berger, Christy L.; Hijazi, Amal S.; Reite, Martin

doi:10.1016/s0031-9384(96)00370-8

Cited by 52 publications

(22 citation statements)

References 30 publications

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“…The stress-reducing properties of familiar companions persist into adulthood in squirrel monkeys, but appears to require the presence of more than a single companion (Coe et al, 1982;Vogt et al, 1981); however see also Hennessy (1984). Studies in rhesus (Gunnar et al, 1980;Gust et al, 1994) and bonnet (Boccia et al, 1997) macaques describe similar stress-reducing benefits of social companions and suggest that for some measures of stress (T-cell suppression) a single familiar companion can effectively buffer stress effects. These data provide strong evidence that social companions can effectively modulate the effects of stress in nonhuman primates.…”

Section: Discussionmentioning

confidence: 99%

Rearing Effects on Cerebrospinal Fluid Oxytocin Concentration and Social Buffering in Rhesus Monkeys

Winslow

Noble

Lyons

et al. 2002

Neuropsychopharmacol

297

204

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Mother-reared (MR) and nursery-reared (NR) male rhesus monkeys exhibit profound and persistent differences in social and emotional behavior. Compared to MR animals, NR monkeys show reduced reciprocal social behaviors and increased agonistic behavior and high levels of stereotypy. Cerebrospinal fluid oxytocin (CSF OT) in NR monkeys was significantly reduced compared to MR monkeys measured at 18, 24, and 36 months of age. Correlations between OT and individual social behavioral profiles measured across rearing conditions also revealed a significant association between OT and the expression of affiliative social behaviors including allogrooming and reciprocal intermale mounting at each age examined. In contrast, CSF vasopressin levels did not differ according to rearing history, but did correlate with fearful behaviors independent of rearing history. Differential rearing was not associated with differences in basal or stressrelated plasma cortisol, although these levels did progressively decline as monkeys matured. MR but not NR monkeys were able to use a social companion to buffer their response to a stressor, but OT levels did not appear to be sensitive to the presence of a social companion in either group. These results are consistent with earlier reports from studies of rodents suggesting an important role for central OT pathways in the development of social affiliation.

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Section: Discussionmentioning

confidence: 99%

Rearing Effects on Cerebrospinal Fluid Oxytocin Concentration and Social Buffering in Rhesus Monkeys

Winslow

Noble

Lyons

et al. 2002

Neuropsychopharmacol

297

204

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“…These studies demonstrated that sex differences in cell-mediated and humoral immune function are enhanced by social housing in polygynous voles (18,20). Therefore, in general, short days enhance immune responses (25,31), and nonagonistic social relationships facilitate recovery from immune challenges (5,11,17).…”

mentioning

confidence: 93%

Social environment modulates photoperiodic immune and reproductive responses in adult male white-footed mice(Peromyscus leucopus)

Pyter¹,

Neigh²,

Nelson³

2005

American Journal of Physiology-Regulatory, Integrative and Comp

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Social cues may interact with photoperiod to regulate seasonal adaptations in photoperiod-responsive rodents. Specifically, photoperiod-induced adjustments (e.g., reproduction and immune function) may differ among individuals in heterosexual pairs, same-sex pairs, or isolation. Heterosexual cues may be more influential, based on their potential fitness value, than same-sex cues or no social cues. The present study examined the effects of pair (with a male or female) or individual housing on reproductive and immune responses in male white-footed mice ( Peromyscus leucopus) maintained in long or short photoperiods. Female pairing did not affect reproductive responses in short-day males. In long days, however, the presence of a female increased both testosterone concentrations and testes mass compared with individually housed and male-paired mice, respectively. Short-day, individually housed males enhanced delayed-type hypersensitivity (DTH) responses compared with single-housed mice in long days, but all paired groups decreased DTH responses regardless of photoperiod. The lack of enhanced DTH response in male mice paired with females coincided with reduced circulating corticosterone concentrations in both photoperiod treatments. Together, these results suggest that social environment may have important modulatory effects on photoperiod-regulated immune responses in male white-footed mice.

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“…Fleshner went on to elegantly show that individual differences in the KLH response could be accounted for by differences in the behavior of individual rats responding to the behavioral challenge of territorial intrusion (Fleshner, Laudenslager, Simons, & Maier, 1989). Similarly in NHP models, influences of behavioral patterns and social interactions affected the way in which immune markers were disrupted (Boccia, Laudenslager, Broussard, & Hijazi, 1992; Boccia et al, 1997; Laudenslager et al, 1993). Purely psychological challenges were effective as physical challenges in modulation of immune readouts.…”

Section: Animal Modelsmentioning

confidence: 99%

“Anatomy of an Illness”: Control from a caregiver’s perspective

Laudenslager

2014

Brain, Behavior, and Immunity

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Caregivers of loved ones with chronic illnesses experience an uncontrollable challenge with potentially negative behavioral and medical consequences. Extensive research has demonstrated immune and endocrine regulation can be significantly disrupted by negative behavioral factors based on both animal models and human studies. However, fewer studies have focused on how psychosocial interventions might reverse the negative consequences of stressors such as caregiving. The distress of caring for individuals with cancer has only recently begun to receive attention. These interventions addressing caregiver distress are rare overall and caregivers of patients receiving hematopoietic stem cell transplants (HSCT) have received even less attention. HSCT caregivers report feelings of loss of control. Animal studies suggest that control over aversive events can mitigate the negative consequences of stressors. Caregivers of allogeneic HSCT patients for blood cancers must be available 24/7 for three months or longer following stem cell infusion to closely monitor the recipients’ health and well-being. Does establishing a greater sense of control have positive impacts on caregivers? A randomized control trial of a cognitive behavioral stress management intervention for allogeneic HSCT caregivers is briefly described. A model of caregiver mental health which may potentially impact the patient’s quality of life is proposed. These relationships exist in a complex system that includes genetic influences, sex, social environment, and prior experience. This system fits well within recent formulations of a “complexity science” approach to health and well-being.

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Juvenile Friends, Behavior, and Immune Responses to Separation in Bonnet Macaque Infants

Cited by 52 publications

References 30 publications

Rearing Effects on Cerebrospinal Fluid Oxytocin Concentration and Social Buffering in Rhesus Monkeys

Rearing Effects on Cerebrospinal Fluid Oxytocin Concentration and Social Buffering in Rhesus Monkeys

Social environment modulates photoperiodic immune and reproductive responses in adult male white-footed mice(Peromyscus leucopus)

“Anatomy of an Illness”: Control from a caregiver’s perspective

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