Juvenile Granulosa Cell Tumor of the Epididymis

Gravas, Stavros; Georgiadis, Thomas; Vassiliadis, Fedon; Kehayas, P.

doi:10.1159/000099352

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Granulosa cells must be present for the diagnosis of GCT [8]. Cells are typically immunopositive for vimentin, inhibin, smooth muscle actin, CD99, and S-100 [9, 18]. Genetically, chromosomal abnormalities such as an atypical Y chromosome and mosaicism may be present [19].…”

Section: Discussionmentioning

confidence: 99%

The Multifaceted Granulosa Cell Tumours—Myths and Realities: A Review

Kanthan

Senger

Kanthan

2012

ISRN Obstetrics and Gynecology

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Background. Granulosa cell tumors (GCTs), representing ~2% of ovarian tumours, are poorly understood neoplasms with unpredictable and undetermined biological behaviour. Design. 5 unusual presentations of GCT and a retrospective 14-year (1997–2011) surgical pathology review based on patient sex, age, tumour type and concurrent pathology findings are presented to discuss the “myths and realities” of GCTs in the context of relevant evidence-based literature. Results. The 5 index cases included (1) a 5 month-old boy with a left testicular mass, (2) a 7-day-old neonate with a large complex cystic mass in the abdomen, (3) a 76-year-old woman with an umbilical mass, (4) a 64-year-old woman with a complex solid-cystic pelvic mass, and (5) a 45 year-old woman with an acute abdomen. Pathological analysis confirmed the final diagnosis as (1) juvenile GCT, (2) macrofollicular GCT, (3) recurrent GCT 32 years later, (4) collision tumour: colonic adenocarcinoma and GCT, and (5) ruptured GCT. Conclusion. GCT is best considered as an unusual indolent neoplasm of low malignant potential with late recurrences that can arise in the ovaries and testicles in both the young and the old. Multifaceted clinical presentations coupled with the unpredictable biological behaviour with late relapses are diagnostic pitfalls necessitating a high degree of suspicion for accurate clinical and pathological diagnosis.

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Section: Discussionmentioning

confidence: 99%

The Multifaceted Granulosa Cell Tumours—Myths and Realities: A Review

Kanthan

Senger

Kanthan

2012

ISRN Obstetrics and Gynecology

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“…We identified 239 cases of tGrCT, of which 166 (69%) presented with the histological variant juvenile tGrCT and 73 (31%) with adult tGrCT (Table 1 ). Juvenile tGrCT were diagnosed at a mean age of 1.5 years (± 5 SD), with single reports of diagnosis in early adulthood (27 and 34 years) (Gravas et al 2007 ; Lin et al 2008 ). Patients with adult tGrCT were diagnosed at a mean age of 42 years (± 19 SD).…”

Section: Methodsmentioning

confidence: 99%

“…Local recurrence 3 months after TSS was reported in one patient (1/20, 5%). After receiving a salvage hemiscrotectomy, the patient remained disease free for at least 18 months (Gravas et al 2007 ). Seven patients (3%) with intra-abdominal cryptorchidism underwent laparotomy.…”

Section: Methodsmentioning

confidence: 99%

Risk factors and treatment outcomes of 239 patients with testicular granulosa cell tumors: a systematic review of published case series data

Grogg

Schneider

Bode

et al. 2020

J Cancer Res Clin Oncol

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Purpose Testicular granulosa cell tumors (tGrCT) are rare sex cord-stromal tumors. This review aims to synthesize the available evidence regarding the clinical presentation and clinicopathological characteristics, treatment and outcomes. Methods We conducted a systematic literature search using the most important research databases. Whenever feasible, we extracted the data on individual patient level. Results From 7863 identified records, we included 88 publications describing 239 patients with tGrCT. The majority of the cases were diagnosed with juvenile tGrCT (166/239, 69%), while 73/239 (31%) patients were diagnosed with adult tGrCT. Mean age at diagnosis was 1.5 years (± 5 SD) for juvenile tGrCT, and 42 years (± 19 SD) for adult tGrCT. Information on primary treatment was available in 231/239 (97%), of which 202/231 (87%) were treated with a radical orchiectomy and 20/231 (9%) received testis sparing surgery (TSS). Local recurrence after TSS was observed in 1/20 (5%) cases. Metastatic disease was never observed in men with juvenile tGrCT but in 7/73 (10%) men with adult tGrCT. In 5/7 men with metastatic tGrCT, metastases were diagnosed at initial staging, while 2/7 patients developed metastases after 72 and 121 months of follow-up, respectively. Primary site of metastasis is represented by the retroperitoneal lymph nodes, but other sites including lungs, liver, bone and inguinal lymph nodes can also be affected. In comparison with non-metastatic adult tGrCT, men with metastatic adult tGrCT had significantly larger primary tumors (70 vs 24 mm, p 0.001), and were more likely to present with angiolymphatic invasion (57% vs 4%, p 0.002) or gynecomastia (29% vs 3%, p 0.019). In five out of seven men with metastatic disease, resection of metastases or platinum-based chemotherapy led to complete remission. Conclusion Juvenile tGrCT represent a benign entity whereas adult tGCTs have metastatic potential. Tumor size, presence of angiolymphatic invasion or gynecomastia represent risk factors for metastatic disease. The published literature supports the use of testis sparing surgery but there is only limited experience with adjuvant therapies. In the metastatic setting, the reviewed literature suggests that aggressive surgical and systemic treatment might cure patients.

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Sex Cord-Stromal Tumors

2022

Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues

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Juvenile Granulosa Cell Tumor of the Epididymis

Abstract: We report the first case of a juvenile granulosa cell tumor of the epididymis in a young man. Clinical and histological findings are presented and the clinical significance of the case is discussed.

Cited by 3 publications

References 6 publications

The Multifaceted Granulosa Cell Tumours—Myths and Realities: A Review

The Multifaceted Granulosa Cell Tumours—Myths and Realities: A Review

Risk factors and treatment outcomes of 239 patients with testicular granulosa cell tumors: a systematic review of published case series data

Sex Cord-Stromal Tumors

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