Juvenile laryngeal papillomatosis with pulmonary parenchymal spread

Abstract

A 6.5-year-old boy developed laryngeal papillomas at 20 months of age and pulmonary parenchymal spread at age 3.5 years, the lung lesions beginning as solid nodules which rapidly cavitated. The cavitary lesions have stabilized in size but no appreciable improvement has resulted from trials of bleomycin, methotrexate, or interferon. A review of 14 other cases indicates that the lung lesions may develop many years after the onset of laryngeal papillomatosis, and the lung lesions do not tend to regress spontaneously as uncomplicated juvenile laryngeal papillomas often do. Three of 15 patients developed carcinomas in their lung lesions without prior therapeutic irradiation.

Papilomatose respiratória recorrente com disseminação pulmonar: relato de dois casos

“…Williams et al (7) relataram três casos de crianças com papilomatose laringo-tráqueobrônquica complicada e descreveram, além das lesões nodulares, alterações secundárias como atelectasia, infecção e bronquiectasias. Kawanami e Bowen (9) relataram um caso de rápida evolução, diagnosticado aos 20 meses de idade e com complicação no parênquima pulmonar aos 3,5 anos, ressaltando-se que os nódulos sólidos não regrediram, mesmo com tratamento.…”

Successful Treatment of Juvenile Laryngeal Papillomatosis-Related Multicystic Lung Disease With Cidofovir

“…20 Chest radiographs have shown persistent postobstructive atelectasis, 7,10 recurrent airspace consolidation, 6,10,11,18 recurrent pneumothoraces, 1 and nodules with and without cavitation. 6,8,[12][13][14]17 Chest CT scans have demonstrated multiple nodules, with or without cavitation, as well as thin-walled cysts.…”

Solitary squamous cell papilloma of the lung in a 40‐year‐old woman with recurrent laryngeal papillomatosis

“…Lung lesions do not tend to regress spontaneously, while uncomplicated laryngeal papillomas often do. 15 Surgical excision is the only definitive therapy. Most investigators have used a carbon dioxide laser or cupped forceps.…”