Juvenile ossifying fibroma: Psammamatoid variant

Aggarwal, Shivani; Garg, Ashish; Aggarwal, Ashim; Ahuja, Nitin K.; Rehman, Farzan

doi:10.4103/0976-237x.103630

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Most of them usually occur in extra-gnathic bones; some could be localized in maxillary and craniofacial bones but rarely found in mandibular bones. Their clinical symptoms are variable such as swelling of face, expanding hard mass, inflammation of sinuses, obstruction of nasal cavity, teeth displacement, eye proptosis, and pain (Aggarwal et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Potential role of myofibroblasts in behavior of oral ossifying fibroma

Ghani

Masloub

Ahmed

et al. 2023

Egyptian Dental Journal

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Review: Benign Fibro-osseous lesions is a generic term that includes a group of diseases affecting jaw and facial bones. Myofibroblasts (MFs) are cells that share properties of fibroblasts and smooth muscle cells. They have a main role in tissue growth, development and healing, and during organ fibrosis and cancers. Alpha smooth muscle actin (α-SMA) is recognized to be present in smooth muscle cells, myoepithelial cells and pericytes. So it used to identify soft tissue neoplasms of smooth muscle, myoepithelial and myofibroblastic origin. Ki67 is one of the markers which is used to detect cellular proliferation in growing cells. Aim of study:The present study aimed to examine the immunohistochemical labeling of α-SMA in juvenile ossifying fibromas (JOFs), central ossifying fibromas (COFs) and peripheral ossifying fibromas (POFs) and to correlate its expression with their proliferative ability through Ki67 expression.Material and Methods: Immunohistochemical expression of α-SMA and Ki67 was evaluated in 10 samples of each of JOF, COF, and POF.Results: JOFs showed the highest mean value of α-SMA and Ki67 expression (16.69±5.25) (17.04±2.75) followed by COFs group (5.93±1.94) (8.33±1.23) while POFs showed the lowest mean value (1.54±0.64) (3.14±0.95), respectively, with a statistically significant positive correlation between α-SMA and Ki67 in all groups together (P-value ≤0.05). Conclusion:Overexpression and significant positive correlation between α-SMA and Ki67 expression in JOFs, COFs, and POFs indicate the important role of MFs in the aggressive behavior of JOFs when compared with COFs and POFs through enhancing cellular proliferation, cellular migration, angiogenesis, and extracellular proteolytic activity and influencing matrix formation.

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Section: Discussionmentioning

confidence: 99%

“…Some cases of trauma to facial bones were reported as the possible cause for the JOFs occurrence. Due to its progressive behavior and as it recurred frequently, early diagnosis and complete surgical removal is mandatory (Aggarwal et al, 2012).…”

Section: Discussionmentioning

confidence: 99%