Juvenile-Versus Adult-Onset Spondyloarthritis

Weiss, Pamela F.; Roth, Johannes

doi:10.1016/j.rdc.2020.01.003

Cited by 13 publications

(12 citation statements)

References 67 publications

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“…Within the International League of Associations for Rheumatology (ILAR), classification criteria for PsA and enthesitis-related arthritis are analogous to the CASPAR and ASAS criteria used in adults but they are quite different in that a variety of exclusion criteria move patients to other categories depending on certain factors. 8,9 For example, a patient with HLA-B27, a first degree relative with HLA-B27-associated disease, a positive rheumatoid factor, or a systemic presentation of JIA would be excluded from having a diagnosis of PsA 9 (Table 2). The ILAR criteria are the most commonly used criteria, however, an alternative juvenile PsA, the Vancouver Criteria, were developed in 1989 though are rarely used today.…”

Section: Epidemiologymentioning

confidence: 99%

Psoriatic arthritis

FitzGerald

Ogdie

Chandran

et al. 2021

Nat Rev Dis Primers

171

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Section: Epidemiologymentioning

confidence: 99%

Psoriatic arthritis

FitzGerald

Ogdie

Chandran

et al. 2021

Nat Rev Dis Primers

171

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“…Nonetheless, IL-23 overexpression in an HLA-B27-negative mouse model was still sufficient to trigger peripheral ankylosing enthesitis and appeared to bypass the requirement for mechanical overload, which signified that IL-23-dependent mechanisms may still be relevant in JSpA ( 48 ). While approximately a third of JSpA patients develop axial symptoms within several years of disease onset, peripheral disease is strongly associated with disease onset before 16 years of age ( 56 ). Thus, IL-23 could be critical especially in JSpA disease initiation and further research should focus on resolving this quandary of IL-23 dependence to inform therapeutic strategies.…”

Section: New Data On the Link Between Inflammation And New Bone Formationmentioning

confidence: 99%

“…These techniques should complement plain radiography by concurrently assessing enthesitis as well as its associated bone marrow oedema, bone erosion, and enthesophyte formation in peripheral SpA and JSpA ( 65 , 66 ). Yet, age-related anatomical variations (e.g., physiologic subchondral oedema vs. pathological bone marrow oedema in children) may confound interpretations of inflammatory and structural lesions in JSpA, particularly in the absence of pediatric-specific definitions ( 56 ). Even so, the increased resolution of the entheseal organ and adjacent bony ultrastructure will prove invaluable in supplementing mechanistic studies to address why inflammation and new bone formation co-localize in JSpA.…”

Section: New Data On the Link Between Inflammation And New Bone Formationmentioning

confidence: 99%

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Juvenile Spondyloarthritis: What More Do We Know About HLA-B27, Enthesitis, and New Bone Formation?

Yeo

Leong

et al. 2021

Front. Med.

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Juvenile spondyloarthritis (JSpA) refers to a diverse spectrum of immune-mediated inflammatory arthritides whose onset occurs in late childhood and adolescence. Like its adult counterpart, JSpA is typified by a strong association with human leukocyte antigen-B27 (HLA-B27) and potential axial involvement, while lacking rheumatoid factor (RF) and distinguishing autoantibodies. A characteristic manifestation of JSpA is enthesitis (inflammation of insertion sites of tendons, ligaments, joint capsules or fascia to bone), which is commonly accompanied by bone resorption and new bone formation at affected sites. In this Review, advances in the role of HLA-B27, enthesitis and its associated osteoproliferation in JSpA pathophysiology and treatment options will be discussed. A deeper appreciation of how these elements contribute to the JSpA disease mechanism will better inform diagnosis, prognosis and therapy, which in turn translates to an improved quality of life for patients.

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“…According to ILAR criteria, ERA is defined either by the association of both arthritis and enthesitis, or only one, with at least 2 of the following items: Sacroiliac joint tenderness, inflammatory back pain, HLA-B27 positivity, family history of HLA-B27–associated diseases, uveitis, or onset in a male aged 6 years or older. 4 …”

Section: Introductionmentioning

confidence: 99%