Juxtaaortic Counterpulsation: Comparison with Intraaortic Counterpulsation in an Animal Model of Acute Heart Failure

Abstract

This study was designed to compare the effects of juxtaaortic balloon counterpulsation (JABC), performed in ascending aorta and the aortic arch, with those yielded by intraaortic balloon counterpulsation (IABC) in descending aorta, in experimental animals during induced cardiac failure.JABC was achieved with a manufactured Dacron prosthesis and a balloon pump placed between the prosthesis and the wrapped aorta.JABC resulted in a significant increase of cardiac output (from 2.33 ؎ 0.82 to 2.61 ؎ 1.12 L/min, p < 0.05), cardiac index (from 0.071 ؎ 0.025 to 0.080 ؎ 0.033 L/min/kg, p < 0.05) and diastolic pressure augmentation evaluated through diastolic and systolic areas beneath the aortic pressure curve (DABAC/SABAC) index (from 0.94 ؎ 0.21 to 1.10 ؎ 0.33, p < 0.01). End diastolic aortic pressure showed a significant decrease with JABC (from 31.90 ؎ 7.09 to 27.83 ؎ 9.72 mm Hg, p < 0.05). A close association between percentage of DABAC/SABAC increases obtained with IABC and JABC was observed (r 2 ‫؍‬ 0.67; p < 0.001).Counterpulsation obtained by a juxtaaortic catheter placed in the arch and the ascending wrapped aorta results in an effective hemodynamic improvement comparable with that achieved by an intraaortic catheter in open chest sheep.

Increased reversal and oscillatory shear stress cause smooth muscle contraction‐dependent changes in sheep aortic dynamics: role in aortic balloon pump circulatory support

“…It is to note that the IABP circulatory support is employed in pathological conditions and we have studied the IABP effects in such conditions (i.e. heart failure) (Cabrera‐Fischer et al. 2004).…”

Adventitia‐dependent mechanical properties of brachiocephalic ovine arteries in in vivo and in vitro studies

“…Diameter and pressure signals were measured by means of a reliable ultrasonic dimension technique and high fidelity solid‐state sensors, respectively. These techniques and the data analysis methodology have been extensively used by our group (Cabrera Fischer et al. 2002, 2004, Armentano et al.…”