Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases

Sperga, Māris; Monzon, Federico A.; Tan, Puay Hoon; Thomas, Anjula; Petersson, Fredrik; Gatalica, Zoran; Ghazalpour, Anatole; Bender, Ryan; Grossmann, P.; Michal, Michal; Švajdler, Marián; Ovčak, Zdenka; Hora, Milan; Hes, Ondřej

doi:10.1016/j.humpath.2012.04.006

Cited by 42 publications

(37 citation statements)

References 32 publications

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“…Histologically, JGCT consists of sheets of polygonal or spindle-shaped cells and a hemangiopericytic angioarchitecture (3). It is occasionally difficult to differentiate a JGCT from an SFT or MN (3,10,11).…”

Section: Discussionmentioning

confidence: 99%

“…It is occasionally difficult to differentiate a JGCT from an SFT or MN (3,10,11). Each of these three tumors is composed of spindle cells, and has a similar morphology and CD34 e�pression pattern.…”

Section: Discussionmentioning

confidence: 99%

“…To date, ~100 cases of JGCT have been reported (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), however, few studies have systematically summarized its characteristic manifestations on computed tomography (CT) and magnetic resonance imaging (MRI) (4,5). JGCT is characterized by renin production, hypokalemia and hypertension (5).…”

Section: Introductionmentioning

confidence: 99%

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Juxtaglomerular cell tumor: A case report

Yang

Wang

2015

Oncology Letters

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Abstract. The current study reports the case of a 29-year-old female with a long-standing history of hypertension and headaches who presented to the Outpatient Clinic of The Central Hospital of Lishui (Lishui, Zhejiang, China). Abdominal ultrasound and contrast-enhanced computed tomography were performed, which showed a left renal neoplasm, prompting a diagnosis of renal angiomyolipoma or renal cell carcinoma. After a laparoscopic partial nephrectomy was performed, a number of different diagnoses were suggested by several pathologists from eight hospitals. Considering the patient's gender, age, medical history, histopathological features and immunohistochemistry, a final diagnosis of a juxtaglomerular cell tumor (JGCT) was established. The present study therefore indicates that the possibility of a JGCT should be considered when young adults present with renal parenchymatous tumors and high blood pressure. In addition, pathologists must take clinical information into account to form a precise diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Juxtaglomerular cell tumor: A case report

Yang

Wang

2015

Oncology Letters

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“…Renovascular disease [renal artery stenosis (RAS)], renal parenchymal disease (renal dysplasia, scarring, glomerulonephritis), or renin-secreting tumors (Wilms’ tumor, reninoma) are the most common diagnoses. Reninomas are an uncommon but well-described cause of renin-mediated hypertension with about 100 reported cases to date (3). …”

Section: Introductionmentioning

confidence: 99%

Reninoma: An Uncommon Cause of Renin-Mediated Hypertension

et al. 2014

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Reninoma (juxtaglomerular cell tumor) is a rare cause of renin-mediated hypertension. Reninomas are usually diagnosed in adolescents and young adults with occasional reports in younger children. Patients typically present with a long history of headaches leading to a diagnosis of severe hypertension that responds well to antihypertensive treatment targeting the renin-angiotensin-aldosterone system. The clue to clinical diagnosis is the presence of hypokalemia and metabolic alkalosis on the first blood sample drawn before any treatment is instituted. Elevated blood levels of renin and aldosterone confirm the clinical suspicion of renin-mediated hypertension. Diagnostic imaging is employed to identify the source of excessive renin production. While renal ultrasound can miss reninoma, contrast CT or magnetic resonance imaging of the kidneys are diagnostic modalities of choice leading to the correct diagnosis. Renal vein renin sampling with lateralization might help to identify the site of excessive renin production. Nephron-sparing surgery is curative with maintenance of normal blood pressure after discontinuation of antihypertensive medications in the majority of patients. In this paper, we present the case of reninoma in an adolescent girl emphasizing clinical presentation, diagnostic evaluation, and medical and surgical treatment of this rare tumor. We also discuss important points in the management of children presenting with renin-mediated hypertension.

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“…To date, approximately 110 cases of JCT have been reported in the English literature (2)(3)(4)(5)(6)(7)(8). Patients with JCT are clinically characterized by hypertension with hyperaldosteronism secondary to excessive renin secretion by the tumor.…”

Section: Introductionmentioning

confidence: 99%

Juxtaglomerular Cell Tumor that was Preoperatively Diagnosed Using Selective Renal Venous Sampling

et al. 2013

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We herein report the case of a patient with a juxtaglomerular cell tumor (JCT). Dynamic enhanced computed tomography revealed a small nodule on the surface of the lower pole of the right kidney. Selective renal venous sampling showed an elevated level of plasma renin activity (PRA) in the right lower pole renal vein only. We performed right partial nephrectomy and diagnosed the patient with JCT. Making a diagnosis of JCT is often difficult due to the small size of the tumor and the lack of lateralization of the PRA on renal venous sampling. This case highlights the importance of performing selective renal venous sampling for the preoperative diagnosis of JCT.

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Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases

Cited by 42 publications

References 32 publications

Juxtaglomerular cell tumor: A case report

Juxtaglomerular cell tumor: A case report

Reninoma: An Uncommon Cause of Renin-Mediated Hypertension

Juxtaglomerular Cell Tumor that was Preoperatively Diagnosed Using Selective Renal Venous Sampling

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