2019
DOI: 10.1248/bpb.b18-00983
|View full text |Cite
|
Sign up to set email alerts
|

Juzentaihoto Suppresses Muscle Atrophy in Streptozotocin-Induced Diabetic Mice

Abstract: In diabetic patients, skeletal muscle atrophy occurs due to increased oxidative stress and inflammation. Skeletal muscle atrophy reduces the QOL of patients and worsens life prognosis. Therefore, development of preventive therapy for muscle atrophy in hyperglycemic state is eagerly awaited. Juzentaihoto is a medicinal herb that has a function to supplement physical strength, and it is expected to prevent muscle atrophy. To determine the preventive effect of juzentaihoto on muscle atrophy in hyperglycemic state… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
6
0

Year Published

2020
2020
2025
2025

Publication Types

Select...
4
1

Relationship

2
3

Authors

Journals

citations
Cited by 9 publications
(7 citation statements)
references
References 30 publications
1
6
0
Order By: Relevance
“…33) Furthermore, previous studies also suggested that JTT administration suppresses skeletal muscle atrophy by reducing the production of inflammatory cytokines and increasing the activity of antioxidant enzymes by elevating Sirt1 levels in streptozotocin-induced diabetic mice. 19,20) In this study, JTT increased Sirt1 mRNA expression in the GA of SAMP8 mice. There was a significant correlation between Sirt1 mRNA expression, and muscle fiber cross-sectional areas of GA (r = 0.719, p < 0.001) (Fig.…”
Section: Fig 7 Jtt Increased Mrna Expression Of Ubiquitin Ligase Mrsupporting
confidence: 55%
See 4 more Smart Citations
“…33) Furthermore, previous studies also suggested that JTT administration suppresses skeletal muscle atrophy by reducing the production of inflammatory cytokines and increasing the activity of antioxidant enzymes by elevating Sirt1 levels in streptozotocin-induced diabetic mice. 19,20) In this study, JTT increased Sirt1 mRNA expression in the GA of SAMP8 mice. There was a significant correlation between Sirt1 mRNA expression, and muscle fiber cross-sectional areas of GA (r = 0.719, p < 0.001) (Fig.…”
Section: Fig 7 Jtt Increased Mrna Expression Of Ubiquitin Ligase Mrsupporting
confidence: 55%
“…In that study, the beneficial effect was observed in mice that received 4% (w/w) JTT mixed feed. 19,20) Therefore, in this study, JTT was mixed with normal feed (CLEA, Shizuoka, Japan) at 4% (w/w).…”
Section: Preparation Of Jtt Extracts-containing Chowmentioning
confidence: 99%
See 3 more Smart Citations