K�ltediurese beim unnarkotisierten Hund

Pabst, K.; Thron, H. L.

doi:10.1007/bf00362939

Cited by 15 publications

(2 citation statements)

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“…Though our concern was mainly with the effect of temperature changes on endocrine function rather than on renal function, we took the opportunity of observing any possible renal effects of the temperature changes and ADH levels. It was not perhaps surprising that a cold environment never elicited a 'cold diuresis' in our pigs as this appears to be a somewhat variable and inconsistent phenomenon in other species (Pabst & Thron, 1960;Bader et al 1952). We might have expected to see some increase in urinary osmolality accompanying the very high plasma ADH levels seen during whole-body heating but these high ADH levels were so transient that any renal effects were difficult to observe.…”

Section: Exposure To Thermally Neutral Conditionsmentioning

confidence: 75%

“…Exposure to a high ambient temperature decreases urinary flow and raises plasma ADH in men (Weiner, 1944;Segar & Moore, 1968) and increases the antidiuretic activity in the serum of rats (Itoh, 1954). Conversely, at cool ambient temperatures, some mammals show the phenomenon of 'cold diuresis' (Pabst & Thron, 1960;Bader, Eliot & Bass, 1952). It was recently observed (Szczepanska-Sadowska, 1974) that in dogs heating a thermode implanted in the pre-optic region of the hypothalamus, a region known to contain temperature-sensing neurones, caused an increase in plasma ADH level and urinary osmolality and a decrease in urinary volume, even when the dogs had been allowed to drink sufficient fluid to initiate a water diuresis, a condition calculated to suppress ADH secretion.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of various ambient temperatures and of heating and cooling the hypothalamus and cervical spinal cord on antidiuretic hormone secretion and urinary osmolality in pigs.

Forsling¹,

Ingram²,

Stanier³

1976

The Journal of Physiology

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SUMMARY1. Plasma ADH concentration, urinary and plasma osmolality and -haematocrit were measured in young pigs placed in cold, thermoneutral, warm and hot ambient temperatures. In some experiments a thermode placed in the hypothalamus or over the cervical spinal cord was heated or cooled at various ambient temperatures.2. Plasma ADH concentration remained at a low level (0.5-5 ,uu. ml.-') over 2 hr or 3 hr periods when the pigs were in cold, thermoneutral or warm ambient temperatures. A hot environment, which caused a marked rise in the pigs' rectal temperature, was associated with a large rise in plasma ADH level.3. The rise in plasma ADH level which occurred during an increase in body temperature was consistently and completely suppressed by simultaneous cooling of the thermode in the pre-optic region to 5 or 10°C. When the thermode was in the region of the supraoptic nucleus the rise in ADH was only partly suppressed, and when it was over the cervical cord it was only sometimes suppressed. 4. Cooling the thermodes in any position at a cold or thermoneutral ambient temperature, or heating them at a thermoneutral or warm ambient temperature, caused no consistent change in ADH.5. A diuresis, with a urinary flow-rate of at most 1 ml. min-and minimal urinary osmolality of 53 m-osmole kg-', was observed on only three occasions, twice during cooling of a thermode in the hypothalamus and once after the end of a period when the thermode was heated. In each case, the plasma ADH was less than 2 /su. ml.-'.M. L. FORSLING AND OTHERS 6. A slight rise of haematocrit in cold ambient conditions and a slight fall in the warm were observed. Otherwise changes in haematocrit were trivial, and a shift of water between vascular system and interstitium could not be invoked to account for changes in ADH levels. Observed variation of plasma osmolality was also slight.

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Section: Exposure To Thermally Neutral Conditionsmentioning

confidence: 75%