Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Wang, Siyu; Zhao, Hui; Xu, Hongtao; Han, Xiao-dong; Wu, Yunshan; Xu, Fangfang; Yang, Xiaobo; Göransson, Ulf; Liu, Bo

doi:10.3389/fphar.2021.675350

Cited by 34 publications

(23 citation statements)

References 78 publications

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“…Kaempferia galanga ( K. galanga ) is an aromatic herb grown mainly in tropical and subtropical Asia ( 19 ) and is used in the treatment of cold, dry cough, toothaches, rheumatism, hypertension, and so on ( 20 ). Modern pharmacological investigations have revealed that the extracts and natural products identified from K. galanga exhibited comprehensive bioactivities, including antitumor, antioxidant, anti-inflammatory, and other health effects ( 21 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

The antihyperglycemic effect of pulsed electric field-extracted polysaccharide of Kaempferia elegans officinale on streptozotocin induced diabetic mice

Lei

Woo

et al. 2022

Front. Nutr.

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Kaempferia elegans polysaccharide (KEP) was extracted using a high-voltage pulsed electric field-assisted hot water method. Its physicochemical properties, in vitro activity and hypoglycemic effect was investigated. Experiments were undertaken with diabetic mice models and the potential mechanism of KEP to improve blood glucose levels was unveiled through measurements of relevant indicators in the serum and liver of the mice. Results showed that KEP is mainly composed of glucose, rhamnose, arabinose, and galactose. It has certain DPPH and ABTS free radical scavenging ability and good α-glucosidase inhibitory ability, indicating that KEP has the potential to improve blood glucose levels in diabetes patients. The experimental results of KEP treatment on mice showed that KEP could control the continuous increase of fasting blood glucose levels. The potential mechanisms behind this blood glucose level control composes of (1) increasing the glucokinase and C peptide levels and decreasing Glucose-6-phosphatase content for improving key enzyme activity in the glucose metabolism pathway. This promotes the consumption of blood glucose during glycolysis, thereby inhibiting the production of endogenous glucose in gluconeogenesis pathway; (2) reducing triglyceride, total cholesterol, low density lipoprotein cholesterol, and increasing high density lipoprotein cholesterol content, for regulating blood lipid indicators to normal levels; and (3) by improving the activities of catalase, glutathione peroxidase, and antioxidant enzymes superoxide dismutase for further improving the antioxidant defense system in the body to reduce blood glucose.

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Section: Introductionmentioning

confidence: 99%

The antihyperglycemic effect of pulsed electric field-extracted polysaccharide of Kaempferia elegans officinale on streptozotocin induced diabetic mice

Lei

Woo

et al. 2022

Front. Nutr.

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“…It was shown to inhibit TNF‐ α ‐induced signaling transduction in L929 cells and attenuate ear inflammation in an acute mouse model. Kaempferol, extracted mainly from Kaempferol galanga L , is widely found in many edible plants and herbal medicines, [ 25 ] and is known for its anti‐inflammatory and anti‐oxidative effects. [ 26 ] Significantly, kaempferol has been shown to attenuate the severity of arthritis in a collagen‐induced arthritis (CIA) mouse model.…”

Section: Discussionmentioning

confidence: 99%

A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo

Wang

Shi

et al. 2022

Advanced Science

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Tumor necrosis factor 𝜶 (TNF-𝜶) inhibitors have shown great success in the treatment of autoimmune diseases. However, to date, approved drugs targeting TNF-𝜶 are restricted to biological macromolecules, largely due to the difficulties in using small molecules for pharmaceutical intervention of protein-protein interactions. Herein the power of a natural product-enriched DNA-encoded library (nDEL) is exploited to identify small molecules that interfere with the protein-protein interaction between TNF-𝜶 and the cognate receptor. Initially, to select molecules capable of binding to TNF-𝜶 , "late-stage" DNA modification method is applied to construct an nDEL library consisted of 400 sterically diverse natural products and pharmaceutically active chemicals. Several natural products, including kaempferol, identified not only show direct interaction with TNF-𝜶, but also lead to the blockage of TNF-𝜶/TNFR1 interaction. Significantly, kaempferol attenuates the TNF-𝜶 signaling in cells and reduces the 12-O-tetradecanoylphorbol-13acetateinduced ear inflammation in mice. Structure-activity-relationship analyses demonstrate the importance of substitution groups at C-3, C-7, and C-4' of kaempferol. The nDEL hit, kaempferol, represents a novel chemical scaffold capable of specifically recognizing TNF-𝜶 and blocking its signal transduction, a promising starting point for the development of a small molecule TNF-𝜶 inhibitor for use in the clinical setting.

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“…It has shown various activities including anti-inflammatory, analgesic, and antioxidant effects, due to their secondary metabolites content. 12 , 13 K. galanga L. is easy to grow in Indonesia and other countries on the Asian continent. 14 The results of our preliminary study have identified the content of ethyl- p -methoxycinnamate (EPMC) and flavonoids in the ethanolic extract of K. galanga L. rhizome.…”

Section: Introductionmentioning

confidence: 99%

“… 15 We also have reported that the best percentage of yield and water, as well as the secondary metabolites content, was obtained from plants harvested in the rainy season. 16 The phytochemical screening of K. galanga L. rhizome indicated the presence of: kaempferol; 12 , 13 EPMC and ethyl cinnamate, that have showed anti-inflammatory and antinociceptive activity better than that of indomethacin as the COX inhibitor 17 and aspirin; 18 quinones and terpenes; 19 polyphenols and flavonoids. 15 It has been reported in a study that diarylheptanoids can be isolated from K. galanga and stated to have a potential effect for the treatment of diseases associated with inflammation.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats

Wahyuni¹,

Sufiawati²,

Nittayananta³

et al. 2022

JIR

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Introduction Kaempferia galanga L. ( K. galanga ; local name kencur , Zingiberaceae) is a plant commonly used as a kitchen spice, and empirically it is often used for medicinal purposes. This plant has been shown to have an anti-inflammatory role, but no research has been found on its effect on oral mucosal ulcer. This study aimed to investigate anti-inflammatory activity and wound healing effect of the ethanol extract of K. galanga L. rhizome (EEKG) on the chemical-induced oral mucosal ulcer in Wistar rats. Methods In this study, 35 rats were divided into 7 groups (normal, negative, triamcinolone acetonide, and 4 EEKG groups). Acetic acid 70% was used as the oral mucosal ulcer inducer. Parameters observed were macroscopic and microscopic histopathological examinations. Results The results revealed that dose of 0.5% of the EEKG was effective in increasing the percent recovery of ulcer area and inflammation sign scores. Meanwhile, doses of 0.5–2% of EEKG were effective in reducing the histopathological score. Interestingly, topical EEKG in our study was more effective compared with triamcinolone acetonide (the conventional therapy for oral mucosal ulceration). Discussion The EEKG has been confirmed its anti-inflammatory activity by accelerating the healing process on the chemical-induced oral mucosal ulcer in Wistar rats, based on the percent recovery of the ulcer area, the percent recovery of the inflammation sign score, and the histopathology score. Conclusion Taken together, K. galanga L. is very potential to be developed as a prospective phytopharmaceutical for the treatment of oral mucosal ulceration in human after clinical trials.

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Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Cited by 34 publications

References 78 publications

The antihyperglycemic effect of pulsed electric field-extracted polysaccharide of Kaempferia elegans officinale on streptozotocin induced diabetic mice

The antihyperglycemic effect of pulsed electric field-extracted polysaccharide of Kaempferia elegans officinale on streptozotocin induced diabetic mice

A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo

Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats

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