Kaempferia Sp. Extracts as UV Protecting and Antioxidant Agents in Sunscreen

Panyakaew, Jukreera; Chalom, Sirinrat; Sookkhee, Siriwoot; Saiai, Aroonchai; Chandet, Nopakarn; Meepowpan, Puttinan; Thavornyutikarn, Praput; Mungkornasawakul, Pitchaya

doi:10.1080/10496475.2020.1777614

Cited by 15 publications

(20 citation statements)

References 25 publications

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“…The ethanolic rhizome extract of K. galanga and its main constituent 34 were evaluated for their UV protective properties. The results demonstrated K. galanga presented high UVB protection with SPF range of 8.57–22.34 μg/ml, and its main constituent 34 also demonstrated UV protective effect ( Panyakaew et al, 2020 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 98%

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Wang

Zhao

et al. 2021

Front. Pharmacol.

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K. galanga is an aromatic medicinal herb. It is locally to India and distributed in China, Myanmar, Indonesia, Malaysia, and Thailand. K. galanga is a Traditional Chinese Herb Medicine (TCHM), which has been applied to treat cold, dry cough, toothaches, rheumatism, hypertension and so on. In addition, it has been used widely as spices since its highly aromas. The aim of this review is to compile and update the current progresses of ethnomedicinal uses, phytochemistry, pharmacology and toxicology of K. galanga. All the data on K. galanga were based on different classical literary works, multiple electronic databases including SciFinder, Web of Science, PubMed, etc. The results showed that ninety-seven compounds have been identified from rhizome of K. galanga, including terpenoids, phenolics, cyclic dipeptides, flavonoids, diarylheptanoids, fatty acids and esters. Modern pharmacology studies revealed that extracts or secondary metabolites of the herb possessed anti-inflammatory, anti-oxidant, anti-tumorous, anti-bacterial, and anti-angiogenesis effects, which were closely related to its abundant ethnomedicinal uses. In conclusion, although previous research works have provided various information of K. galanga, more in-depth studies are still necessary to systemically evaluate phytochemistry, pharmacological activities, toxicity and quality control of this herb.

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Section: Pharmacological Activitiesmentioning

confidence: 98%

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Wang

Zhao

et al. 2021

Front. Pharmacol.

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“…The area under the absorbance curve was considered to be 100%. λc is the wavelength at which 90% of the area under the absorbance curve is found considering the integral of the absorption spectrum from 290 to 400 nm with a 1.0 cm optical path [20]. For the FDA, a product is considered to have a broad spectrum of photoprotection when its minimum λc is 370 nm [84], i.e., the product must be able to absorb enough UV radiation at a longer wavelength (UVA) [66,67,85].…”

Section: Critical Wavelength (λC)mentioning

confidence: 99%

“…The UVA/UVB ratio is the mean absorbance extinction in the spectral regions that includes both UVA (320 to 400 nm) and UVB (290 to 320 nm) [20]. The measurement of UVA/UVB ratios was determined according to the Boots Star Rating System.…”

Section: Uva/uvb Ratiomentioning

confidence: 99%

“…where A(λ) is the effective absorbance related to the transmittance of the sunscreen. The star rating system indicates that the UVA/UVB ratio in 0.0 to <0.2 is too low for UVA protection (-), 0.2 to <0.4 is a moderate protector (*), 0.4 to <0.6 is a good protector (**), 0.6 to <0.8 is a superior protector (***), and 0.8 to ≥0.8 is a maximum protector (****) [20,84,86,87].…”

Section: Uva/uvb Ratiomentioning

confidence: 99%

“…For decades, EOs have been used in degenerative skin disorders, and today, it is known that many of their protective properties are due to the presence of phenolic and terpene constituents [9,17]. The hydroxyl groups present in phenolic constituents exert antioxidant activity by inactivating free radicals by modulating cellular signaling transduction pathways, restoring the redox homeostasis by regulating cytoprotective responses caused by ROS and electrophiles, and preventing inflammation by enhancing the activities of antioxidant enzymes through the Nrf2 pathway [7,9,18,19]; thus, phenolic compounds reduce inflammation, oxidative stress, and DNA-damaging effects [20]. As photoprotective agents, these molecules have broad-spectrum UV absorption that includes regions between 290 nm and 400 nm.…”

Section: Introductionmentioning

confidence: 99%

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Photoprotective Agents Obtained from Aromatic Plants Grown in Colombia: Total Phenolic Content, Antioxidant Activity, and Assessment of Cytotoxic Potential in Cancer Cell Lines of Cymbopogon flexuosus L. and Tagetes lucida Cav. Essential Oils

Caballero-Gallardo

Quintero-Rincón

Stashenko

et al. 2022

Plants

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Photoprotective agents obtained from plants provide benefits for the health of the skin. The present study aims to assess the total phenolic content (TPC) and in vitro UV-protective properties of twelve essential oils (EOs) from plants grown in Colombia and to evaluate the antioxidant and cytotoxic potential of two species identified as photoprotective potentials: Cymbopogon flexuosus and Tagetes lucida. The composition of EOs was studied by GC/MS. The cytotoxicity of both EOs was examined using an MTT assay, and an H2-DCFDA probe was employed to estimate the intracellular production of ROS in HepG2 and Calu-1 cells. Major constituents (≥10%) were neral, geranial, geranyl acetate in C. flexuosus and estragole in T. lucida. The TPC for C. flexuosus and T. lucida EOs were ≥10 mg GAE/g byproduct. Both EOs showed photoprotective properties (SPFin vitro: 13–14), and long-wavelength UVA protection (λc > 370 nm). HepG2 and Calu-1 cells exposed to C. flexuosus exhibited antiproliferative activity (˂50%) at 125 µg/mL, while T. lucida was at 250 and 500 µg/mL. The IC50 values for C. flexuosus were 75 and 100 µg/mL in HepG2 and Calu-1 cells, respectively, whereas those for T. lucida were >250 µg/mL. These EOs achieved significant inhibitory effects (between 15.6 and 40.4%) against H2O2-induced oxidative stress. The results showed that EO compounds recognized as antioxidants could counteract the effects elicited by H2O2.

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Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics

Anh Van,

Duc,

Son

2023

Med Chem Res

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Kaempferia Sp. Extracts as UV Protecting and Antioxidant Agents in Sunscreen

Cited by 15 publications

References 25 publications

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses

Photoprotective Agents Obtained from Aromatic Plants Grown in Colombia: Total Phenolic Content, Antioxidant Activity, and Assessment of Cytotoxic Potential in Cancer Cell Lines of Cymbopogon flexuosus L. and Tagetes lucida Cav. Essential Oils

Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics

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