Kaempferol and inflammation: From chemistry to medicine

Devi, Kasi Pandima; Malar, Dicson Sheeja; Nabavi, Seyed Fazel; Sureda, Antoni; Xiao, Jianbo; Daglia, Maria

doi:10.1016/j.phrs.2015.05.002

Cited by 479 publications

(260 citation statements)

References 191 publications

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“…Kaempferol and quercetin present in this natural products are widely reported and reviewed to ameliorate inflammation under both in vitro and in vivo conditions. [4445]…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Nociceptive Activities of Stem-Bark Extracts and Fractions of Carpolobia Lutea (Polygalaceae)

Nwidu

Airhihen

Ahmadu

2017

J Basic Clin Pharma

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Background:In Niger Delta, ethnomedicine hydroalcoholic extract of Carpolobia lutea (CL) (Polygalaceae) is used to relieve inflammatory pains.Objectives:The purpose of this study is to evaluate the anti-inflammatory and antinociceptive effects of ethanolic stem extract (ESE) and to fractionate the ESE for the elucidation of bioactive molecules.Materials and Methods:The antinociceptive effects for ESE were tested against two noxious stimuli; chemical (acetic acid-induced writhing and formalin-induced pain) and thermal (hot plate) stimuli. The effects of paracetamol (130 mg/kg), indomethacin (10 mg/kg), and morphine (5 mg/kg) pretreatment were investigated. To isolate the bioactive compounds with anti-inflammatory effect, two doses (86.6 and 173.2 mg/kg) of four fractions (methanol fraction MTF, ethyl acetate fraction EAF, chloroform fraction CHF, and n-hexane fraction n-HF) obtained from fractionating ESE were utilized. Carrageenan, egg albumin, and capsaicin-induced edema of the hind paw of the rats were the models adopted. Paw volume was measured by a digital vernier caliper from 0 to 6 h after injection. This was compared to standard drugs. The results were subjected to statistical analysis.Results:The ESE decreased significantly (P < 0.001) the writhing of acetic acid-induced abdominal contractions and licking of formalin-induced pains but does not have any effects on the hot plate test. Of the four fractions obtained, the EAFs demonstrated a significant (P < 0.001) inflammatory inhibition of 98.97% and 41.91% at 86.6 and 173.2 mg/kg, respectively, compared to 65.75% inhibition demonstrated by the reference drug, acetylsalicylic acid (100 mg/kg) on the carrageenan model while 36.36% and 29.87% inhibition of inflammation at 86.6 and 173.2 mg/kg, respectively, on the egg albumin models; there was no significant effect on the capsaicin model.Conclusion:The isolation of quercetin and kaemferol from CL gave credence to its anti-inflammatory and antinociceptive effects.

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“…Kaempferol and quercetin present in this natural products are widely reported and reviewed to ameliorate inflammation under both in vitro and in vivo conditions. [4445]…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Nociceptive Activities of Stem-Bark Extracts and Fractions of Carpolobia Lutea (Polygalaceae)

Nwidu

Airhihen

Ahmadu

2017

J Basic Clin Pharma

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“…43 Similarly, quercetin has been described as anti-inflammatory in several study models 44 and kaempferol reported as an effective compound against inflammation. 45 These data make it possible to attribute the anti-inflam matory activity of the MEPaL to the presence of gallic acid derivatives and flavonoids such as the derivatives of quercetin, myricetin and kaempferol. However, further investigations should be carried out to determine the structure and content of P. atlantica glycosylated flavonoids.…”

Section: 33mentioning

confidence: 99%

Anti-inflammatory Activity of Methanolic Extract from Pistacia atlantica Desf. Leaves

Amri¹,

Zekhnini²,

Bouhaimi³

et al. 2017

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Introduction:The extracts of the Pistacia species are known for their anti-inflammatory activity, including fruits and oil of P. atlantica. However, the inflammatory effect of the methanolic extract of P. atlantica leaves has not been studied. This work aimed at assessing the antiinflammatory and antioxidant activities of P. atlantica leaves extract in relation to phytochemical studies of flavonoids. Methods: The extract was obtained using sonication of leaves powder in 80 % methanol. The analysis of phenolic compounds was carried out using thin-layer chromatography (TLC). The antioxidant activity was evaluated using DPPH, ABTS and FRAP assays. The anti-inflammatory activity was determined by the reduction of carrageenaninduced hind paw edema in mice. Results: The TLC revealed 3 glycosylated flavonoids and gallic acid derivatives. The flavonoids identified corresponded to rutin, quercetrin and other heterosides of quercetin, kaempferol and myricetin. Total phenolics and flavonoids contents were comparable for the male and female trees. The antioxidant activity did not show a significative difference between the two sexes, except for that evaluated by the FRAP assay which was significantly greater for the male tree leaves extract. The leaves extract permitted significative reduction of the edema at h3 and 6 in a dose-dependent manner (100 and 250 mg/kg), while diclofenac used as control reduced the edema at h 1.5. This difference could be explained by the pharmacokinetic and pharmacodynamic properties of diclofenac and P. atlantica leaves compounds. Conclusion: P. atlantica has a strong anti-inflammatory activity and constitutes a potential source for the development of new treatments. Key words: Antioxidant activity, Flavonoids, Methanolic extract, Plantar edema, TLC. Oukacha ulcers.4 This has led to the search for alternative treatments. In this regard, secondary metabolites of various medicinal plants have been shown to be effective in the treatment of inflammation and pain.5 Among these plants, the species of Pistacia genus are of interest. Indeed, this genus includes 11 species that are widely distributed on the different continents of the terrestrial globe. They are found in temperate forests, tropical hardwoods and boreal conifers.6 P. atlantica is one of the most widespread wildlife species. It is the most characteristic plant of the arid and semi-arid zones of the northern part of Africa.7 In traditional medicine, P. atlantica is used for the treatment of pain and other conditions such as upper abdominal discomfort, dyspepsia and peptic ulcer.8 Several studies reported that the different parts of the plant as fruits, galls and oil, have biological effects including anti-inflammatory activities.9-12 However, as far as we know, no work has been devoted to the study of the anti-inflammatory effect of the methanolic extract of P. atlantica leaves (MEPaL). Thus, this study aimed at assessing the anti-inflammatory activity of DPPH scavenging activityThe antiradical power of substances was measured ...

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“…The previous studies have confirmed its properties of anti-inflammation, anti-oxidation, anti-microbes, and anti-cancer, which can be used in the treatment of cancer, cardiovascular diseases, infection, etc [15, 16]. It also has cardioprotective properties, such as improving myocardial ischemia/reperfusion injury of the rats by inhibiting oxidative stress, endoplasmic reticulum stress and GSK-3β signal pathway [17], and improving doxorubicin-induced cardiotoxicity [18].…”

Section: Introductionmentioning

confidence: 99%

Kaempferol Alleviates Angiotensin II-Induced Cardiac Dysfunction and Interstitial Fibrosis in Mice

Liu

Gao

Guo

et al. 2017

Cell Physiol Biochem

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Background/Aims: Endothelial-to-mesenchymal transition (EndMT) is a mechanism that promotes cardiac fibrosis induced by Angiotensin II (AngII). Kaempferol (KAE) is a monomer component mainly derived from the rhizome of Kaempferia galanga L. It shows anti-inflammatory, anti-oxidative, anti-microbial and anti-cancer properties, which can be used in the treatment of cancer, cardiovascular diseases, infection, etc. But, its effects on the development of cardiac remodelling remain completely unknown. The aim of the present study was to determine whether KAE attenuates cardiac hypertrophy induced by angiotensin II (Ang II) in cultured neonatal rat cardiac myocytes in vitro and cardiac hypertrophy induced by AngII infusion in mice in vivo. Methods: Male wild-type mice aged 8-10 weeks with or without KAE were subjected to AngII or saline, to induce fibrosis or as a control, respectively. Morphological changes, echocardiographic parameters, histological analyses, and hypertrophic markers were also used to evaluate hypertrophy. Results: KAE prevented and reversed cardiac remodelling induced by AngII. The KAE in this model exerted no basal effects but attenuated cardiac fibrosis, hypertrophy and dysfunction induced by AngII. Both in vivo and in vitro experiments demonstrated that Ang II infusion or TGF-β induced EndMT can be reduced by KAE and the proliferation and activation of cardiac fibroblasts (CFs) can be inhibited by KAE. Conclusions: The results suggest that KAE prevents and reverses ventricular fibrosis and cardiac dysfunction, providing an experimental basis for clinical treatment on ventricular fibrosis.

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Kaempferol and inflammation: From chemistry to medicine

Cited by 479 publications

References 191 publications

Anti-Inflammatory and Anti-Nociceptive Activities of Stem-Bark Extracts and Fractions of Carpolobia Lutea (Polygalaceae)

Anti-Inflammatory and Anti-Nociceptive Activities of Stem-Bark Extracts and Fractions of Carpolobia Lutea (Polygalaceae)

Anti-inflammatory Activity of Methanolic Extract from Pistacia atlantica Desf. Leaves

Kaempferol Alleviates Angiotensin II-Induced Cardiac Dysfunction and Interstitial Fibrosis in Mice

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